. . "Lysosomal Proteinases and their Inhibitors - Structural and Functional Relationship"@en . "5"^^ . "5"^^ . . "http://www.isvav.cz/projectDetail.do?rowId=IAA455105"^^ . "Lysozom\u00E1ln\u00ED proteinasy a jejich inhibitory - vztah struktury a funkce" . . . . "1"^^ . . . . "XXX"@cs . . "0"^^ . "Aktivita lysosom\u00E1ln\u00EDch proteinas je regulov\u00E1na v n\u011Bkolika \u00FArovn\u00EDch a poru\u0161en\u00ED na kter\u00E9koli z nich m\u016F\u017Ee v\u00E9st k z\u00E1va\u017En\u00FDm pathologick\u00FDm stav\u016Fm. Z\u00E1klad pro pochopen\u00ED t\u011Bchto mechanism\u016F je t\u0159eba hledat na strukturn\u00ED basi. C\u00EDlem na\u0161eho projektu proto je: a) ur\u010Dit posttransla\u010Dn\u00ED modifikaci prim\u00E1rn\u00ED struktury a glykosylace n\u011Bkolika cysteinov\u00FDch a aspart\u00E1tov\u00FDch lysosom\u00E1ln\u00EDch proteinas (kathepsiny B, C, D, H a S), 2) \u0159e\u0161it jejich prostorov\u00E9 struktury X-paprskovou krystalografi\u00ED (stavbu kathepsinu D jsme nyn\u00ED dokon\u010Dili), 3) nal z\u00E1klad\u011B t\u011Bchto v\u00FDsledk\u016F vysv\u011Btlit substr\u00E1tovou specificitu a strukturn\u00ED determinaci jejich transportu do lysosom\u00E1ln\u00EDho kompartmentu, 4) charakterizovat interakci s inhibitory; studium inhibitoru bude zam\u011B\u0159eno na p\u0159irozen\u00E9 proteinov\u00E9 inhibitory a stavbu jejich reaktivn\u00EDch center." . "0"^^ . . . "IAA455105" . .