"Kl\u00ED\u010Dovou su\u010D\u00E1st\u00ED \u017Eivotn\u00EDho cyklu retrovir\u016F je \u0161t\u011Bpen\u00ED polypeptidov\u00FDch prekursor\u016F na zral\u00E9 virov\u00E9 komponenty vysoce specifickou virem k\u00F3dovanou proteasou. Vzhledem k tomu, \u017Ee regulace t\u00E9to proteasy je v\u00FDznamn\u00FDm kontroln\u00EDm mechanismem v \u017Eivotn\u00EDm cyklu retrovir\u016F, st\u00E1v\u00E1 se tato proteasa atraktivn\u00EDm c\u00EDlem pro v\u00FDvoj l\u00E9k\u016F nemoc\u00ED zp\u016Fsoben\u00FDch t\u011Bmito viry, jako je nap\u0159. AIDS. Vy\u0161t\u011Bpen\u00ED proteasy z polyproteinov\u00E9ho prekursoru a dimerizace na jej\u00ED aktivn\u00ED formu jsou z\u00E1kladn\u00ED nevy\u0159e\u0161en\u00E9 ot\u00E1zky v \u017Eivotn\u00EDm cyklu retrovir\u016F, stejn\u011B jako \u00FA\u010Dinn\u00E1 inhibice tohoto enzymu. K \u0159e\u0161en\u00ED t\u011Bchto probl\u00E9m\u016F pou\u017Eijeme 3 modely, proteasy z r\u016Fzn\u00FDch typ\u016F retrovir\u016F: i) HIV-1, ii) viru hov\u011Bz\u00ED leuk\u00E9mie, iii) opi\u010D\u00EDho Mason-Pfizerova viru. Enzymy budou exprimov\u00E1ny v E. coli, izolov\u00E1ny prokinetick\u00E9 studie a pro v\u00FDzkum autokatalytick\u00E9ho \u0161t\u011Bpen\u00ED a testov\u00E1n\u00ED inhibitor\u016F. \u00DA\u010Dinn\u00E9 inhibitory c\u00EDlen\u00E9 proti aktivn\u00EDmu m\u00EDstu a dimeriza\u010Dn\u00ED dom\u00E9n\u011B budou navr\u017Eeny pomoc\u00ED po\u010D\u00EDta\u010Dov\u00E9ho modelov\u00E1n\u00ED a testov\u00E1ny." . . . . . . "Studium aktivace a inhibice retrovirov\u00FDch proteas" . . . . . "8"^^ . "8"^^ . "0"^^ . "http://www.isvav.cz/projectDetail.do?rowId=IAA4055503"^^ . "1"^^ . . . "Study of the activation and inhibition of retroviral proteases"@en . . . "IAA4055503" . "0"^^ .