"C\u00EDlem projektu je objasnit roli hydrofobn\u00EDch a hydrofiln\u00EDch interakc\u00ED v konforma\u010Dn\u00ED struktu\u0159e, stabilit\u011B a dynamice dvou typ\u016F polymern\u00EDch syst\u00E9m\u016F na b\u00E1zi peptid\u016F vyu\u017E\u00EDvan\u00FDch jako nosi\u010De l\u00E9\u010Div: syntetick\u00FDch polypentapeptid\u016F elastinov\u00E9ho typu a vlokov\u00FDch kopolymer\u016F polyethylenglykolu s oligopeptidy. Hlavn\u00EDmi metodami studia budou Ramanova a infra\u010Derven\u00E1 spektroskopie, jadern\u00E1 magnetick\u00E1 rezonance a kvantov\u011B mechanick\u00E9 v\u00FDpo\u010Dty, dopln\u011Bn\u00E9 DSC, WAXS a SAXS. Bude sledov\u00E1n vliv p\u0159\u00EDtomnosti molekul vody na strukturu a dynamiku studovan\u00FDch syst\u00E9m\u016F v \u0161irok\u00E9m koncentra\u010Dn\u00EDm rozsahu od pevn\u00FDch l\u00E1tek se sorbovan\u00FDmi molekulami vody a\u017E po z\u0159ed\u011Bn\u00E9 vodn\u00E9 roztoky. Projekt bude p\u0159edev\u0161\u00EDm soust\u0159ed\u011Bn na studium kr\u00E1tk\u00FDch peptidick\u00FDch \u00FAsek\u016F a stavebn\u00EDch blok\u016F uveden\u00FDch polymern\u00EDch syst\u00E9m\u016F. \u0158e\u0161en\u00ED projektu napom\u016F\u017Ee p\u0159i designu syntetick\u00FDch polymer\u016F s vlastnostmi vhodn\u00FDmi pro specifick\u00E9 biologick\u00E9 \u00FA\u010Dely." . "Studium hydrofobn\u00EDch a hydrofiln\u00EDch interakc\u00ED ve vodn\u00FDch roztoc\u00EDch bioanalogick\u00FDch polymer\u016F" . . . . . . . . . "Byla podrobn\u011B zdokumentov\u00E1na a objasn\u011Bna role hydrofobn\u00EDch a hydrofiln\u00EDch interakc\u00ED v konforma\u010Dn\u00ED struktu\u0159e a dynamice elastinov\u00FDch polypentapeptid\u016F a blokov\u00FDch kopolymer\u016F; v\u00FDsledky lze vyu\u017E\u00EDt pro design polymer\u016F k biol\u00E9ka\u0159sk\u00FDm \u00FA\u010Del\u016Fm."@cs . "Study of hydrophobic and hydrophilic interactions in water solutions of bioanalogous polymers"@en . " vibrational spectroscopy" . "2007-09-26+02:00"^^ . " bioanalogous copolymers" . . . "The aim of the project is to clarify the role of hydrophobic and hydrophilic interactions in the konformational structure, stability and dynamics in two peptide-based polymer systems utilized as drug arriers: synthetic polypentapeptides of elastin type and block copolymers of poly(ethylene glycol) with oligopeptides. Main methods will be Raman and infrared spectroscopy, nuclear magnetic resonance, and quantum mechanical calculations, supported by DSC, SAXS, and WAXS. The influence of the presence of water molecules on the structure and dynamics of the studied systems will be followed in a broad concentration range from solid state with sorbed water molecules to diluted water solutions. Project will be mainly focused on the study of short peptides and building blocks of the investigated polymer systems. The project will help in the design of synthetic polymers with properties suitable for specific biological proposes."@en . . . "hydrophobic end hydrophillic interactions" . "10"^^ . "hydrophobic end hydrophillic interactions; structure and dynamids; vibrational spectroscopy; NMR; quantum chemical calculations; bioanalogous copolymers; poly(ethylene glycol); oligopeptides"@en . . "10"^^ . " quantum chemical calculations" . . "The role of hydrophobic and hydrophilic interactions in the conformational structure and dynamics of elastin polypentapeptides and block copolymers was documented and clarified in view of their utilization for design of polymers with biomedical use."@en . "0"^^ . " poly(ethylene glycol)" . "1"^^ . . " structure and dynamids" . . "0"^^ . . "IAA4050208" . " NMR" . . . . "http://www.isvav.cz/projectDetail.do?rowId=IAA4050208"^^ .