. "Structure-Activity Study of VIP and Related Peptides"@en . . . "Strukturn\u011B-aktivn\u00ED studie peptid\u016F skupiny VIP zahrnuje jak syntheticko-chemick\u00FD tak biochemicko-farmakologick\u00FD p\u0159\u00EDstup. Projekt je d\u011Blen do n\u00E1sleduj\u00EDc\u00EDch f\u00E1z\u00ED: 1) chemick\u00E1 synthesa analog\u016F VIPu s c\u00EDlem identifikace chemick\u00FDch skupin v molekule peptidu kritick\u00FDch pro vazbu na receptor a projev biologick\u00E9 aktivity, 2) v\u00FDvoj nov\u00FDch analog\u016F se zv\u00FD\u0161en\u00FDm \u00FA\u010Dinkem \u010Di selektivitou, p\u0159\u00EDprava aktivn\u00EDch fragment\u016F a kompetitivn\u00EDch antagonist\u016F, 3) p\u0159\u00EDprava specifick\u00FDch ligand\u016F pro receptorov\u00E9 studie, afinitn\u00ED a radioaktivn\u00ED zna\u010Den\u00ED a isolaci solubilizovan\u00FDch receptor\u016F. U nov\u011B synthetisovan\u00FDch l\u00E1tek se o\u010Dek\u00E1v\u00E1, vedle p\u0159\u00EDsp\u011Bvku k objasn\u011Bn\u00ED mechanismu \u00FA\u010Dink\u016F VIPu, diagnostick\u00E9 a terapeutick\u00E9 vyu\u017Eit\u00ED. XXX" . . . . . . . "Strukturn\u011B-aktivitn\u00ED studie peptid\u016F skupiny VIP" . "IA75579" . . "0"^^ . "1"^^ . "0"^^ . "http://www.isvav.cz/projectDetail.do?rowId=IA75579"^^ . "1"^^ . . . "1"^^ . .