. "http://www.isvav.cz/projectDetail.do?rowId=IA71157"^^ . "\u00DA\u010Dinky antiepileptik v nezral\u00E9m mozku" . "0"^^ . . . . . "Action of Antiepileptic Drugs in Immature Brain"@en . "1"^^ . "V na\u0161\u00ED laborato\u0159i jsme popsali kvalitativn\u00ED i kvantitativn\u00ED zm\u011Bny \u00FA\u010Dink\u016F antiepileptik b\u011Bhem v\u00FDvoje. Tento projekt je zam\u011B\u0159en p\u0159edev\u0161\u00EDm na ta antiepileptika, kter\u00E1 m\u011Bn\u00ED \u00FA\u010Dinky kvalititivn\u011B - ethosuximid a phenytoin. Bude p\u0159esn\u011B vymezen v\u00FDvojov\u00FD stupe\u0148, kdy tyto l\u00E1tky m\u011Bn\u00ED \u00FA\u010Dinek, budeme studovat jejich c\u00EDlov\u00E9 struktury a mo\u017En\u00E9 interakce s medi\u00E1torov\u00FDmi syst\u00E9my. Stanovov\u00E1n\u00ED plasmatick\u00FDch a mozkov\u00FDch hladin antiepileptik vymez\u00ED mo\u017En\u00E9 farmakokinetick\u00E9 d\u016Fvody zm\u011Bn \u00FA\u010Dinku. Screeningov\u00FDmi metodami budeme zji\u0161\u0165ovat p\u0159\u00EDpadn\u00E1 dal\u0161\u00ED antiepileptika s kvalitativn\u00EDmi zm\u011Bnami \u00FA\u010Dinku. Mezi l\u00E1tkami, kter\u00E9 m\u011Bn\u00ED svoji \u00FA\u010Dinnost pouze kvantitativn\u011B, budeme studovat p\u0159edev\u0161\u00EDm ty, kter\u00E9 p\u016Fsob\u00ED na GABAergn\u00ED inhibi\u010Dn\u00ED syst\u00E9m. V\u00FDsledky budou m\u00EDt p\u0159\u00EDmou projekci do d\u011Btsk\u00E9 neurologie." . . . . . "22"^^ . . "0"^^ . "IA71157" . . "22"^^ . .