"1"^^ . "Rational design and synthesis of retroviral proteinase inhibitors derived from natural peptide substrates by modification of an amide bond"@en . "0"^^ . . . . . . . "Retrovir\u00E1ln\u00ED prote\u00E1zy jsou kl\u00ED\u010Dov\u00FDmi enzymy v \u017Eivotn\u00EDm cyklu v\u0161ech retrovir\u016F, v\u010Detn\u011B HIV. Inhibice prote\u00E1zy zamezuje replikaci viru a zcela potla\u010Duje jeho infek\u010Dnost. S vyu\u017Eit\u00EDm molekulov\u00E9ho modelov\u00E1n\u00ED a po\u010D\u00EDta\u010Dov\u00E9 grafiky navrhneme a p\u0159iprav\u00EDme kompetitivn\u00ED inhibitory HIV-1 a n\u011Bkter\u00FDch dal\u0161\u00EDch prote\u00E1z efektivn\u00EDch v aktivn\u00EDm m\u00EDst\u011B enzymu. Pro HIV-1 prote\u00E1zu, kter\u00E1 je \u00FA\u010Dinn\u00E1 pouze v dimern\u00ED form\u011B, navrhneme a p\u0159iprav\u00EDme inhibitory br\u00E1n\u00EDc\u00ED asociaci monomern\u00EDch jednotek. \u00DA\u010Dinnost v\u0161ech p\u0159ipraven\u00FDchinhibitor\u016F bude testov\u00E1na in vitro a perspektivn\u00ED inhibitory tak\u00E9 in vivo v tk\u00E1\u0148ov\u00FDch kultur\u00E1ch. XXX" . "IA455101" . "Racion\u00E1ln\u00ED n\u00E1vrh a synteza inhibitor\u016F retrovir\u00E1ln\u00EDch prote\u00E1z zalo\u017Een\u00E1 na peptidech a modifikovanou amidovou vazbou" . . . . "1"^^ . . . "1"^^ . "http://www.isvav.cz/projectDetail.do?rowId=IA455101"^^ . . "0"^^ . .