"86"^^ . . "86"^^ . . "Molekul\u00E1rn\u00ED a bun\u011B\u010Dn\u00E9 z\u00E1klady oogeneze oplozen\u00ED a embryon\u00E1ln\u00EDho v\u00FDvoje savc\u016F" . . . . . "Spolupr\u00E1ce n\u011Bkolika \u0161pi\u010Dkov\u00FDch pracovi\u0161\u0165 na \u0159e\u0161en\u00ED projektu p\u0159inesla mno\u017Estv\u00ED zaj\u00EDmav\u00FDch v\u00FDsledk\u016F, z nich\u017E n\u011Bkter\u00E9 lze hodnotit jako prioritn\u00ED. V\u00FDsledky v\u00FDzkumu mechanism\u016F oplozen\u00ED a embryon\u00E1ln\u00EDho v\u00FDvoje otev\u00EDraj\u00ED perspektivy dal\u0161\u00EDho b\u00E1d\u00E1n\u00ED v t\u00E9to oblast"@cs . "http://www.isvav.cz/projectDetail.do?rowId=GV524/96/K162"^^ . "GV524/96/K162" . "2002-11-19+01:00"^^ . . . . . "3"^^ . "1"^^ . "Neuvedeno."@en . . . . "Results derived from the experiments involved in the proposed grant will potentially shed light not only on biochemical regulation of growth and maturation of mammalian oocytes, but it will allow to develop novel protocols which allow to include growing oocytes in embryo transfer program. Moreover, the role of cell surface proteins, acrosome proteins and tyrosine phosphorylated proteins of mammalian spermatozoa during capacitation, their motility and binding to oocytes will be elucidated upon animal andhuman model. We expect to identify a battery of genes whose expression increases during preimplantation development of bovine embryos. The precise comparison with zygotic gene activation in the mouse will allow to identify the best model system for the human. The mesoderm specification in the mouse embryos will be used to determine mechanism underlying the cellular differentiation and tissue patterning during early vertebrate embryogenesis. Taken together, the project, based upon the recent methodology"@en . "Experiment\u00E1ln\u00ED v\u00FDsledky, z\u00EDskan\u00E9 p\u0159i \u0159e\u0161en\u00ED prvn\u00ED \u010D\u00E1sti p\u0159edkl\u00E1dan\u00E9ho grantu, poskytnou nejen prioritn\u00ED \u00FAdaje o mechanismu regulace r\u016Fstu a zr\u00E1n\u00ED oocyt\u016F na biochemick\u00E9 a molekul\u00E1rn\u00ED \u00FArovni, ale z\u00E1rove\u0148 umo\u017En\u00ED vypracovat metodiku, kter\u00E1 v\u010Dlen\u00ED rostouc\u00ED oocyty do programu p\u0159enosu embry\u00ED. Druh\u00E1 \u010D\u00E1st grantu objasn\u00ED specifick\u00FD v\u00FDznam povrchov\u00FDch i akrozom\u00E1ln\u00EDch protein\u016F a b\u00EDlkovin fosforylovan\u00FDch na tyroz\u00EDnu sav\u010D\u00EDch spermi\u00ED pro pr\u016Fb\u011Bh kapacitace, jejich motilitu a vazbu na oocyt. T\u0159et\u00ED \u010D\u00E1st grantu si kladza c\u00EDl identifikovat soubor gen\u016F, kter\u00E9 jsou exprimov\u00E1ny v pr\u016Fb\u011Bhu \u010Dasn\u00E9ho embryon\u00E1ln\u00EDho v\u00FDvoje u skotu. Sou\u010Dasn\u011B bude na my\u0161\u00EDm modelu prostudov\u00E1n mechanismus diferenciace bun\u011Bk mezodermu v pr\u016Fb\u011Bhu embryogeneze. Cel\u00FD projekt, kter\u00FD je zalo\u017Een na sou\u010Dasn\u00FDch metodick\u00FDch p\u0159\u00EDstupech bun\u011B\u010Dn\u00E9 a molekul\u00E1rn\u00ED biologie, bude \u0159e\u0161it v\u00FDznamn\u00FD soubor ot\u00E1zek reproduk\u010Dn\u00ED biologie se z\u0159etelnou orientac\u00ED na jejich biomedic\u00EDnsk\u00E9 aspekty." . "Cellular and molecular basis of oogenesis fertilization and embryonic development in mammals"@en . . . "0"^^ . .