"0"^^ . . "2002-11-19+01:00"^^ . . . . . . "0"^^ . "Development of Antiviral and Anticancer Drugs with Acyclic Nucleotide Structure: Rational Design Based on Their Interference with Cellular Metabolism."@en . "Protivirov\u00E1 a protirakovinov\u00E1 l\u00E9\u010Diva se strukturou acyklick\u00FDch nukletidov\u00FDch analog\u016F: racion\u00E1ln\u00ED v\u00FDvoj zalo\u017Een\u00FD na jejich z\u00E1sahu do bun\u011B\u010Dn\u00E9ho metabolismu" . . . . "\u0158e\u0161itel\u00E9 studovali l\u00E1tky se strukturou acyklick\u00FDch nukleotidov\u00FDch analog\u016F, zejm\u00E9na z hlediska jejich biologick\u00E9 aktivity jako potenci\u00E1ln\u00EDch l\u00E9\u010Div s virostatick\u00FDm a kancerostatick\u00FDm \u00FA\u010Dinkem. N\u011Bkter\u00E9 l\u00E1tky tohoto typu ji\u017E byly schv\u00E1leny jako l\u00E9\u010Diva (Viread"@cs . "http://www.isvav.cz/projectDetail.do?rowId=GV203/96/K001"^^ . . "Neuvedeno."@en . . . "C\u00EDlem p\u0159edkl\u00E1dan\u00E9ho projektu je racion\u00E1ln\u00ED n\u00E1vrh a synt\u00E9za nov\u00FDch cyklick\u00FDch nukleotidov\u00FDch analog a jejich profarmak odvozen\u00FDch od pyrimidinov\u00FDch a purinov\u00FDch heterocyklick\u00FDch bas\u00ED, kter\u00E9 maj\u00ED cytostatickou, protivirovou, antiparasit\u00E1rn\u00ED, imunomodula\u010Dn\u00EDa jin\u00E9 biologick\u00E9 aktivity; jejich studium na experiment\u00E1ln\u00EDch modelech neoplasmie (karcinomy, sarkomy, lymfomy), virov\u00FDch a parasit\u00E1ln\u00EDch infekc\u00ED in vitro a na neproliferuj\u00EDc\u00EDch, proliferuj\u00EDc\u00EDch a imortalizovan\u00FDch lymfocytech. Praktick\u00FDm v\u00FDstupem navrhovan\u00E9ho projektu je nalezen\u00ED dal\u0161\u00EDch potenci\u00E1ln\u00EDch chemotherapeutik spole\u010Densky z\u00E1va\u017En\u00FDch inemocn\u011Bn\u00ED. Projekt je zalo\u017Een na systematick\u00E9 spolupr\u00E1ci mezi chemickou synt\u00E9zou a biochemick\u00FDm studiem. N\u00E1vrhy nov\u00FDch struktur jsou opro\u0161t\u011Bny od p\u016Fvodn\u00EDch empirick\u00FDch p\u0159\u00EDstup\u016F a budou vych\u00E1zet z poznatk\u016F o bun\u011B\u010Dn\u00E9m transportu, o anabilick\u00FDch p\u0159em\u011Bn\u00E1ch nov\u00FDch analog v bu\u0148ce a ze znalosti vlivu t\u011Bchto struktur na vz\u00E1jemn\u00E9 metabolick\u00E9 p\u0159em\u011Bny prekurzor\u016F nukleov\u00FDch kyselin. Jsme p\u0159esv\u011Bd\u010Deni, \u017Ee zejm\u00E9na systema" . . . "63"^^ . . "The aim of the project is the rational design and synthesis of novel acyclsic nucleotide analogues and their produgs derived from pyrimidine and purine heterocyclic bases with cytostatic, antiviral, antiparasitic, immunomodulatory and/or other biologicalactivities and to study them in experimental models of cancer with different etiology, models of virus and/or protozoan infections in vitro, on resting lymphocytes as well as on immortalised lymphocyte cell lines. In order to rationally proceed with the design and investigation of acyclic nucleotide phosphonates we need to know whether the compounds enter the cell or how to enhance their membrane transport, we must understand what is going on with the compound inside the cell and what are the molecular consequences of its presence. We are convinced that the detailed investigation of nucleoside and nucleotide interconversions in the analog-treated cell lines and systemic qualitative and quantitative investigation of intracellular pool will clarify still"@en . "63"^^ . "GV203/96/K001" . . "1"^^ . .