"Zne\u010Di\u0161t\u011Bn\u00ED ovzdu\u0161\u00ED p\u0159edstavuje z\u00E1va\u017En\u00FD probl\u00E9m dne\u0161ka. P\u0159esto\u017Ee je zn\u00E1mo, \u017Ee vzdu\u0161n\u00E9 polutanty vyvol\u00E1vaj\u00ED u exponovan\u00FDch organizm\u016F \u0159adu toxick\u00FDch \u00FA\u010Dink\u016F, st\u00E1le se pro hodnocen\u00ED zne\u010Di\u0161t\u011Bn\u00ED atmosf\u00E9ry pou\u017E\u00EDvaj\u00ED p\u0159ev\u00E1\u017En\u011B chemick\u00E9 p\u0159\u00EDstupy, kter\u00E9 nejsou schopny detailn\u011B popsat celkov\u00E9 slo\u017Een\u00ED ani toxick\u00E9 efekty komplexn\u00EDch sm\u011Bs\u00ED polutant\u016F. Navrhovan\u00FD projekt vyhodnot\u00ED neb\u00FDvale \u0161irokou \u0161k\u00E1lu biologick\u00FDch efekt\u016F in vitro. Studie pop\u00ED\u0161e cytotoxicitu, genotoxicitu, toxicitu dioxinov\u00E9ho typu, estrogenitu a androgenitu sm\u011Bs\u00ED polutant\u016F p\u0159\u00EDtomn\u00FDch v\u00A0plynn\u00E9 f\u00E1zi vzduch a v \u0161esti respirabiln\u00EDch velikostn\u00EDch frakc\u00EDch vzdu\u0161n\u00E9ho aerosolu. Vzorky vzduchu budou sb\u00EDr\u00E1ny na vybran\u00FDch lokalit\u00E1ch li\u0161\u00EDc\u00EDch se m\u00EDrou a typem zne\u010Di\u0161t\u011Bn\u00ED. Detailn\u00ED shrnut\u00ED sez\u00F3nn\u00ED variability a distribuce biologicky aktivn\u00EDch l\u00E1tek mezi plynnou frakci a jednotliv\u00E9 frakce aerosolu spolu s daty z chemick\u00FDch anal\u00FDz poskytne unik\u00E1tn\u00ED informace, kter\u00E9 mohou poslou\u017Eit k v\u00FDznamn\u00E9mu vylep\u0161en\u00ED hodnocen\u00ED environment\u00E1ln\u00EDch rizik." . . . . . "2014-07-15+02:00"^^ . . . . . . . . "0"^^ . . . "2010-01-01+01:00"^^ . "1"^^ . "Assessment of multiple biological effects of air pollutants mixtures in vitro"@en . "Atmospheric pollution poses an important environmental problem nowadays. Although air pollutants were described to cause many toxic effects in exposed organisms, the mostly used approaches for evaluation of level of air pollution are based on chemical analysis that are able to describe neither overall composition nor the toxicity of the complex mixtures of pollutants. The proposed project will optimize a set of methods and evaluate a complex set of biological effects of the air pollutant mixtures in vitro. It will describe cytotoxicity, genotoxicity, dioxin-like activity, estrogenicity and androgenicity of compounds associated with six inhalable size fractions of air particulate matter and gas phase of air. The air will be sampled at localities differing in pollution characteristics. Overview of seasonal variation and distribution of pollutants eliciting the studied biological effects among the gas and the six particulate fractions compared to data from chemical analyses will provide unique information that may be used for improvement of environmental risk assessment."@en . "GPP503/10/P249" . "Stanoven\u00ED sady biologick\u00FDch efekt\u016F atmosferick\u00FDch polutant\u016F in vitro" . . "3"^^ . "0"^^ . . "3"^^ . . . "http://www.isvav.cz/projectDetail.do?rowId=GPP503/10/P249"^^ . "air pollution AhR-mediated toxicity estrogenicity androgenicity genotoxicity"@en . .