"http://www.isvav.cz/projectDetail.do?rowId=GPP502/10/P362"^^ . " phagocytes" . " Actinobacillus" . "2012-03-30+02:00"^^ . . " oxide" . "GPP502/10/P362" . "Mononukle\u00E1rn\u00ED fagocyty jsou bu\u0148ky nespecifick\u00E9 obrany organismu, kter\u00E9 hraj\u00ED d\u016Fle\u017Eitou roli v obran\u011B proti bakteri\u00E1ln\u00EDm patogen\u016Fm. V pr\u016Fb\u011Bhu posledn\u00EDch let se za\u010D\u00EDn\u00E1 v\u011Bnovat zv\u00FD\u0161en\u00E1 pozornost fenotypick\u00E9 a funk\u010Dn\u00ED heterogenit\u011B t\u011Bchto bun\u011Bk v r\u00E1mci jejich jednotliv\u00FDch subpopulac\u00ED. Informace o funkci t\u011Bchto bun\u011B\u010Dn\u00FDch subpopulac\u00ED u prasat za in vivo podm\u00EDn\u011Bk jsou velmi kus\u00E9 a jsou vyvozov\u00E1ny hlavn\u011B z experiment\u016F proveden\u00FDch in vitro. C\u00EDlem tohoto projektu je z\u00EDskat nov\u00E9 informace o distribuci a funkci mononukle\u00E1rn\u00EDch fagocyt\u016F u prasete na modelu experiment\u00E1ln\u011B indukovan\u00E9ho z\u00E1n\u011Btu po infekci plic bakteri\u00ED Actinobacillus pleuropneumoniae. Kvantifikace a lokalizace mononukle\u00E1rn\u00EDch fagocyt\u016F ve tk\u00E1ni bude provedena za pou\u017Eit\u00ED pr\u016Ftokov\u00E9 cytometrie a imunohistochemie. Funk\u010Dn\u00ED heterogenita t\u011Bchto bun\u011Bk bude vyhodnocena na z\u00E1klad\u011B rozd\u00EDl\u016F v expresi inducibiln\u00ED synt\u00E1zy oxidu dusnat\u00E9ho, cytokin\u016F, chemokin\u016F a receptor\u016F pro chemokiny. Tento projekt p\u0159isp\u011Bje k roz\u0161\u00ED\u0159en\u00ED poznatk\u016F o funkci subpopulac\u00ED mononukle\u00E1rn\u00EDch fagocyt\u016F u prasat." . "mononuclear" . . " synthase" . "0"^^ . "4"^^ . . "2010-01-01+01:00"^^ . "4"^^ . "1"^^ . "The postdoctoral project contributed to elucidating the function of monocytes and their subpopulations in the course of the inflammatory response in pigs, in particular phenotype CD163 positive monocytes."@en . . . . . . "0"^^ . . "2014-01-27+01:00"^^ . "Mononuclear phagocytes are cells of nonspecific immunity, which play an essential role in the defence against main bacterial pathogens. Recently, increasing attention has been paid to phenotypic and functional heterogeneity of these cells in mice and humans. In pigs, information about mononuclear phagocyte heterogeneity and their real in vivo role is still very rare. The general aim of this project is to bring new information about distribution and function of porcine mononuclear phagocytes in a model of experimentally induced lung inflammation after Actinobacillus pleuropneumoniae infection. The quantification and tissue localization of mononuclear phagocytes will be assessed using flow cytometry and immunohistochemistry. The functional properties of these cells will be investigated on the basis of inducible nitric oxide synthase, cytokines, chemokines and chemokine receptor expression. The project will contribute to the enlargement of knowledge on the function of porcine mononuclear phagocyte subpopulations."@en . . "Functional heterogeneity of porcine mononuclear phagocytes during experimentally induced lung inflammation by Actinobacillus pleuropneumoniae"@en . . . . " cytokines" . . "2012-12-31+01:00"^^ . " nitric" . "Postdoktorsk\u00FD projekt p\u0159isp\u011Bl k objasn\u011Bn\u00ED funkce monocyt\u016F a jejich jednotliv\u00FDch subpopulac\u00ED v pr\u016Fb\u011Bhu z\u00E1n\u011Btliv\u00E9 odpov\u011Bdi u prasete, zejm\u00E9na fenotypu CD163 pozitivn\u00EDch monocyt\u016F."@cs . . "Funk\u010Dn\u00ED heterogenita prase\u010D\u00EDch mononukle\u00E1rn\u00EDch fagocyt\u016F po experiment\u00E1ln\u011B vyvolan\u00E9m z\u00E1n\u011Btu plic bakteri\u00ED Actinobacillus pleuropneumoniae" . . "mononuclear; phagocytes; inducible; nitric; oxide; synthase; cytokines; Actinobacillus; pleuropneumoniae"@en . . " inducible" . .