. . . . "2014-06-25+02:00"^^ . . . . "oocyte nucleolus embryo epigenetics"@en . . "2013-12-31+01:00"^^ . "Autorka velmi dob\u0159e popsala pr\u016Fb\u011Bh \u0159e\u0161en\u00ED, k \u00FA\u010Detnictv\u00ED nelze m\u00EDt v\u00FDhrady. V\u00FDstupy publika\u010Dn\u00ED jsou hojn\u00E9 a kvalitn\u00ED, \u0161koda jen, \u017Ee prvoautorsk\u00FD je a\u017E posledn\u00ED, dle v\u0161eho kl\u00ED\u010Dov\u00FD rukopis. Chv\u00E1l\u00EDm snahu vyprodukovat jednu vysoce kvalitn\u00ED publikaci v presti\u017En\u00EDm periodiku. Tato publikace byla ned\u00E1vno p\u0159\u00EDjata k tisku."@cs . . "\u00A0 In somatic cells, the nucleolus is composed from three basic components and is primarily the site of ribosome biogenesis. In fully-grown mammalian oocytes a corresponding structure cannot be observed as these cells contain a so called nucleolus precursor body (NPB). The precise composition and function of this nuclear organelle is currently unknown. With respect to the low transcriptional activity of the fully-grown oocytes, it is clear that the NPB does not serve as the site of massive ribosome production. Thus, it is probable that the NPB serves as the site of sequestration and storage of original nucleolar proteins. At the same time, it is well established that the nucleolus in somatic cells is actually a multifunctional nuclear organelle that is for example involved in cell cycle or epigenetic regulation. Our previous results indicate that the NPB might be in fact also a multifunctional organelle. In the proposed project, we would like to characterize in more detail the composition of the NPB and this in turn will help to establish more precisely its function."@en . . "7"^^ . "Zat\u00EDmco u somatick\u00FDch bun\u011Bk je jad\u00E9rko slo\u017Eeno ze t\u0159\u00ED z\u00E1kladn\u00EDch komponent a je prim\u00E1rn\u011B m\u00EDstem biogeneze ribosom\u016F, u oocyt\u016F savc\u016F s ukon\u010Den\u00FDm r\u016Fstem nen\u00ED mo\u017En\u00E9 obdobnou strukturu pozorovat. V t\u011Bchto specializovan\u00FDch bu\u0148k\u00E1ch je p\u0159\u00EDtomen tzv. prekursor jad\u00E9rka (NPB \u2013 nucleolus precursor body). P\u0159esn\u00E1 funkce a slo\u017Een\u00ED tohoto \u00FAtvaru nejsou v sou\u010Dasn\u00E9 dob\u011B zn\u00E1m\u00E9. Vzhledem k n\u00EDzk\u00E9 transkrip\u010Dn\u00ED aktivit\u011B oocyt\u016F s ukon\u010Den\u00FDm r\u016Fstem je patrn\u00E9, \u017Ee k masivn\u00ED produkci ribosom\u016F v NPB nedoch\u00E1z\u00ED. Je tedy vysoce pravd\u011Bpodobn\u00E9, \u017Ee NPB m\u016F\u017Ee slou\u017Eit jako m\u00EDsto sekvestrace jednotliv\u00FDch protein\u016F, kter\u00E9 poch\u00E1z\u00ED z p\u016Fvodn\u00EDho jad\u00E9rka oocytu. Z\u00E1rove\u0148 je v\u0161ak u somatick\u00FDch bun\u011Bk jad\u00E9rko ch\u00E1p\u00E1no jako multifunk\u010Dn\u00ED organela, kter\u00E1 se pod\u00EDl\u00ED nap\u0159. p\u0159i regulaci bun\u011B\u010Dn\u00E9ho cyklu nebo epigenetick\u00E9 regulaci. Vzhledem k na\u0161im p\u0159edch\u00E1zej\u00EDc\u00EDm v\u00FDsledk\u016Fm je mo\u017En\u00E9, \u017Ee NPB je ve skute\u010Dnosti tak\u00E9 multifunk\u010Dn\u00ED jadern\u00E1 organela. V p\u0159edkl\u00E1dan\u00E9m projektu bychom se r\u00E1di zam\u011B\u0159ili na charakterizaci slo\u017Een\u00ED NPB, a t\u00EDm l\u00E9pe stanovili mo\u017Enou funkci t\u00E9to unik\u00E1tn\u00ED struktury." . "7"^^ . "\u00DAloha a funkce jad\u00E9rka v oogenezi a \u010Dasn\u00E9m embryon\u00E1ln\u00EDm v\u00FDvoji." . . "0"^^ . "GPP302/11/P069" . "Grantee described the progress on her project excellently, the accounting report is excellent as well. The publications are numerous and of high quality, it is unfortunate that the grantee is the lead author only on the last, hitherto unpublished paper. However, I commend on her efforts to produce one, comprehensive high quality paper in a prestigious journal, recently accepted in Development."@en . "1"^^ . . . "2013-06-06+02:00"^^ . . "0"^^ . "2011-01-01+01:00"^^ . "http://www.isvav.cz/projectDetail.do?rowId=GPP302/11/P069"^^ . . "The role of the nucleolus precursor body in oogenesis and early embryonic development"@en . . . .