. . . " encephalitis" . . . . "2012-03-30+02:00"^^ . "tick-borne" . "Role of the blood-brain barrier in tick-borne encephalitis neuropathogenesis"@en . " virus" . "http://www.isvav.cz/projectDetail.do?rowId=GPP302/10/P438"^^ . "8"^^ . . "8"^^ . "2014-01-27+01:00"^^ . "0"^^ . "2012-12-31+01:00"^^ . "Tick-borne encephalitis represents a serious viral disease of human central nervous system. Despite the medical importance of this disease, some crucial steps in the development of encephalitis remain poorly understood. Especially, a route of viral entry to the brain is completely unknown and this needs to be investigated. Proposed Postodoctoral Project is focused on the study of the interaction of tick-borne encephalitis virus with brain microvascular endothelial cells that form the blood-brain barrier. This will be investigated using the most advanced methods of cellular and molecular biology, and using in vitro model of human blood-brain barrier and laboratory mice. Results of this project should improve our understanding of the pathogenesis of tick-borne encephalitis, determine modes how the virus crosses the blood-brain barrier and help to propose candidate drugs blocking viral entry into the central nervous system."@en . "1"^^ . . . . . "0"^^ . . "Grant p\u0159inesl p\u016Fvodn\u00ED n\u00E1lezy z\u00E1kladn\u00EDho v\u00FDzkumu, ale i n\u00E1lezy \u201Etransla\u010Dn\u00ED\u201C. Z\u00E1v\u011Bre\u010Dn\u00E1 zpr\u00E1va je dob\u0159e naps\u00E1na. V\u00FDstupy grantu jsou na postdoc grant vynikaj\u00EDc\u00ED. Neuplatn\u011Bn\u00E9 v\u00FDstupy ji\u017E byly publika\u010Dn\u011B realizov\u00E1ny. Celkem se jedn\u00E1 o v\u00FDsledky: 6 IF publikac\u00ED a 5 kapitol v knih\u00E1ch, \u0159e\u0161itel je editor 1 knihy a spolueditor 2 knih. \u0158e\u0161itel se pod\u00EDlel na v\u011Bdeck\u00E9 v\u00FDchov\u011B mlad\u0161\u00EDch pracovn\u00EDk\u016F."@cs . "Role hematoencefalick\u00E9 bari\u00E9ry v neuropatogenezi kl\u00ED\u0161\u0165ov\u00E9 encefalitidy" . "2010-01-01+01:00"^^ . . . "Grant brought basic research findings and findings of translational research. Report is very well written. Some publications mentioned in the report as not yet realized were already accepted. In total, the count is: 6 publications with IF, 5 book chapters with the PI being editor of 3 books. The PI is for sure involved in the training of younger scientists."@en . "tick-borne; encephalitis; tick-borne; encephalitis; virus; neuropathogenesis; blood-brain; barrier"@en . " neuropathogenesis" . " tick-borne" . . . . . "GPP302/10/P438" . " blood-brain" . "Kl\u00ED\u0161\u0165ov\u00E1 encefalitida p\u0159edstavuje z\u00E1va\u017En\u00E9 virov\u00E9 onemocn\u011Bn\u00ED centr\u00E1ln\u00ED nervov\u00E9 soustavy \u010Dlov\u011Bka. Navzdory v\u00FDznamu t\u00E9to infekce z\u016Fstavaj\u00ED n\u011Bkter\u00E9 kl\u00ED\u010Dov\u00E9 ot\u00E1zky ohledn\u011B vzniku a rozvoje encefalitidy nevyjasn\u011Bny. Zejm\u00E9na nen\u00ED zn\u00E1mo, jak\u00FDm zp\u016Fsobem virus p\u0159ekon\u00E1v\u00E1 hemoatoencefalickou bari\u00E9ru a pronik\u00E1 do mozku hostitele. P\u0159edkl\u00E1dan\u00FD postdoktorsk\u00FD projekt si klade za c\u00EDl studovat interakci viru kl\u00ED\u0161\u0165ov\u00E9 encefalitidy s mikrovaskul\u00E1rn\u00EDmi endoteli\u00E1ln\u00EDmi bu\u0148kami mozku, kter\u00E9 tvo\u0159\u00ED hematoencefalickou bari\u00E9ru, a to s vyu\u017Eit\u00EDm nejmodern\u011Bj\u0161\u00EDch metod molekul\u00E1rn\u00ED a bun\u011B\u010Dn\u00E9 biologie. Studium interakce bude prov\u00E1d\u011Bno jednak na modelu lidsk\u00E9 hematoencefalick\u00E9 bari\u00E9ry v podm\u00EDnk\u00E1ch in vitro, jednak na laboratorn\u00EDch my\u0161\u00EDch. Z\u00EDskan\u00E9 v\u00FDsledky by m\u011Bly p\u0159isp\u011Bt k pozn\u00E1n\u00ED patogeneze tohoto z\u00E1va\u017En\u00E9ho lidsk\u00E9ho virov\u00E9ho onemocn\u011Bn\u00ED a mohly by napomoci n\u00E1vrhu poteci\u00E1ln\u00EDch farmak, br\u00E1n\u00EDc\u00EDch pr\u016Fniku viru do mozku hostitele." .