"Odborn\u00FD p\u0159\u00EDnos projektu lze pova\u017Eovat za velmi v\u00FDznamn\u00FD, co\u017E vypl\u00FDv\u00E1 ji\u017E z impresivn\u00EDho seznamu publika\u010Dn\u00EDch v\u00FDstup\u016F; zna\u010Dn\u00E1 \u010D\u00E1st z nich m\u00E1 velmi slu\u0161n\u00FD IF a nap\u0159. jedna z uveden\u00FDch publikac\u00ED m\u00E1 v sou\u010Dasn\u00E9 dob\u011B ji\u017E 44 citac\u00ED (!). Srovnateln\u011B kvalitn\u00ED publika\u010Dn\u00ED v\u00FDstupy nem\u00E1 cel\u00E1 \u0159ada seniorsk\u00FDch projektu s rozpo\u010Dtem mnohon\u00E1sobn\u011B vy\u0161\u0161\u00EDm. Grant byl po v\u0161ech str\u00E1nk\u00E1ch \u0159\u00E1dn\u011B \u0159e\u0161en."@cs . "Mechanism of catalytical self-cleavage of two non-coding RNAs of human patogens"@en . "2013-06-07+02:00"^^ . "2014-06-25+02:00"^^ . . . . . "Mechanismus katalytick\u00E9ho samo\u0161t\u011Bpen\u00ED dvou nek\u00F3duj\u00EDc\u00EDch RNA lidsk\u00FDch patogen\u016F" . . "GPP301/11/P558" . "14"^^ . . . "2013-12-31+01:00"^^ . "14"^^ . . . . . "0"^^ . . "human patogen RNA catalysis ribozyme reaction mechanism"@en . . "http://www.isvav.cz/projectDetail.do?rowId=GPP301/11/P558"^^ . . "Until 1980s the RNA was assumed to be passive carrier of the genetic information, thus the discovery of catalytic RNA (ribozyme) by Cech and Altman was surprising and awarded by Nobel Prize in 1989. In the following decades molecular biology of RNA underwent a revolution leading to discovery of other ribozymes, riboswitches regulating gene expression, and RNA interference causing gene silencing. These findings can lead into novel strategies in human medicine and therefore it is important to fully understand all functions of non-coding RNA, especially at a molecular level. Despite the progress in this field, many questions remain still unanswered. One of the challenges is to fully understand the nature of the RNA catalysis of ribozymes that play important roles in replication of several human patogens like Hepatitis delta virus. Knowledge of these processes allows us to find a new therapeutic stategies targeting, e.g., these ribozymes. This project focuses on the RNA catalysis of two human pathogen ribozymes: Hepatitis delta virus ribozyme and glmS riboswitch from Bacillus anthracis."@en . "1"^^ . "Doned\u00E1vna se myslelo, \u017Ee RNA je pouze pasivn\u00ED p\u0159ena\u0161e\u010D genetick\u00E9 informace, a proto byl objev katalytick\u00E9 RNA (ribozymu) Cechem a Altmanem p\u0159ekvapiv\u00FD a ocen\u011Bn\u00FD v\u00A0roce 1989 Nobelovou cenou. N\u00E1sleduj\u00EDc\u00ED obdob\u00ED bylo revoluc\u00ED v\u00A0molekul\u00E1rn\u00ED biologii RNA, v\u00A0n\u00ED\u017E k\u00A0nev\u00FDznamn\u011Bj\u0161\u00EDm objev\u016Fm pat\u0159\u00ED vedle objevu ribozym\u016F, i odhalen\u00ED RNA p\u0159ep\u00EDna\u010D\u016F (riboswitch\u016F) reguluj\u00EDc\u00EDch genovou expresi a RNA interference uplat\u0148uj\u00EDc\u00ED se p\u0159i uti\u0161ov\u00E1n\u00ED gen\u016F. Tyto objevy mohou p\u0159in\u00E9st zcela nov\u00E9 sm\u011Bry v\u00A0hum\u00E1nn\u00ED medic\u00EDn\u011B a proto je pochopen\u00ED funkce nek\u00F3duj\u00EDc\u00ED RNA zejm\u00E9na na molekul\u00E1rn\u00ED \u00FArovni velmi \u017E\u00E1douc\u00ED. I p\u0159es zna\u010Dn\u00FD pokrok z\u016Fst\u00E1v\u00E1 \u0159ada ot\u00E1zek v\u00A0t\u00E9to oblasti nezodpov\u011Bzena. Jedn\u00EDm z\u00A0t\u011Bchto probl\u00E9m\u016F je pochopen\u00ED RNA katal\u00FDzy a detailn\u00ED popis reak\u010Dn\u00EDch mechanism\u016F zn\u00E1m\u00FDch ribozym\u016F, kter\u00E9 hraj\u00ED d\u016Fle\u017Eitou \u00FAlohu p\u0159i\u00A0replikaci \u0159ady lidsk\u00FDch patogen\u016F nap\u0159. viru Hepatitidy D. Znalost t\u011Bchto proces\u016F dovol\u00ED hledat cesty pro jejich regulaci a m\u016F\u017Ee tak p\u0159isp\u011Bt k\u00A0v\u00FDvoji zcela nov\u00FDch terapeutik. Projekt bude zam\u011B\u0159en na studium ribozym\u016F dvou lidsk\u00FDch patogen\u016F: ribozymu viru hepatitidy D a glmS riboswitche z Bacillus anthracis." . . . . "0"^^ . . "The scientific level of the outputs of this project is very high. The list of publications is highly impressive and outstanding. Many senior grants with much higher budget do not have such outstanding results and outputs. This is even more evident if taking into the account that this was a three-year postdoc grant with very limited money support."@en . "2011-01-01+01:00"^^ . . .