"In vitro models for study of endocrine disruption - effects of traditional and new types of persistent organic pollutants"@en . " steroidogenesis" . "\u0158e\u0161en\u00ED posdoktorsk\u00E9ho projektu vedlo k validaci \u0161irok\u00E9 s\u00E9rie metod pro studium specifick\u00FDch mechanism\u016F spojen\u00FDch s endokrinn\u00ED disrupc\u00ED. Tato baterie byla vyu\u017Eita jak pro hodnocen\u00ED potenci\u00E1lu xenobiotik pro endokrinn\u011B disruptivn\u00ED p\u016Fsoben\u00ED, tak pro hodnoce"@cs . "2008-10-17+02:00"^^ . . . . . "C\u00EDlem projektu je zaveden\u00ED a validace v \u010CR unik\u00E1tn\u00ED baterie in vitro test\u016F pro detekci potenci\u00E1lu environment\u00E1ln\u00EDch polutant\u016F negativn\u011B ovliv\u0148ovat endokrinn\u00ED syst\u00E9m organism\u016F (endokrinn\u00ED disrupce). Navr\u017Een\u00E9 testy studuj\u00ED interakce xenobiotik s regula\u010Dn\u00EDmi procesy na \u00FArovni receptor\u016F (estrogenn\u00ED, androgenn\u00ED, glukokortikoidn\u00ED, retinoidov\u00FD) a mechanism\u016F steroidogeneze. Metody umo\u017En\u00ED testov\u00E1n\u00ED d\u016Fle\u017Eit\u00FDch polutant\u016F, stejn\u011B jako agrochemik\u00E1li\u00ED, farmaceutik \u010Di komplexn\u00EDch sm\u011Bs\u00ED z environment\u00E1ln\u00EDch vzork\u016F. Projekt p\u0159inese nov\u00E9 informace o potenci\u00E1lu prioritn\u00EDch persistentn\u00EDch organick\u00FDch polutant\u016F (POPs), kter\u00E9 se v\u00FDznamn\u011B pod\u00EDlej\u00ED na zne\u010Di\u0161t\u011Bn\u00ED prost\u0159ed\u00ED v \u010CR, ovliv\u0148ovat endokrinn\u00ED syst\u00E9m specifick\u00FDmi mechanismy. Projekt je zam\u011B\u0159en zejm\u00E9na na dopln\u011Bn\u00ED chyb\u011Bj\u00EDc\u00EDch informac\u00ED o b\u011B\u017En\u011B sledovan\u00FDch POPs a na testov\u00E1n\u00ED nov\u011B prioritn\u00EDch POPs. V\u00FDsledky dopln\u00ED ekotoxikologickou charakteristiku studovan\u00FDch l\u00E1tek a p\u0159isp\u011Bj\u00ED k p\u0159edpov\u011Bdi rizik spojen\u00FDch s kontaminac\u00ED prost\u0159ed\u00ED. V\u00FDstupem budou kvalitn\u00ED" . "0"^^ . . "0"^^ . . . . "1"^^ . " estrogenity" . " androgenity" . "In vitro modely pro studium endokrinn\u00ED disrupce - \u00FA\u010Dinky tradi\u010Dn\u00EDch a nov\u00FDch typ\u016F persistentn\u00EDch organick\u00FDch polutant\u016F" . " RAR/RXR" . . . "2005-01-01+01:00"^^ . . "GP525/05/P160" . . . " receptors" . . "endocrine disruption" . . "32"^^ . . "2007-05-02+02:00"^^ . "32"^^ . "http://www.isvav.cz/projectDetail.do?rowId=GP525/05/P160"^^ . . "2007-12-31+01:00"^^ . . "Project proposes development and validation of a system of in vitro tests for detection of endocrine disruption potential of environmental contaminants that is unique in the Czech Republic. The tests will enable to study interactions of xenobiotics with regulation mechanisms on the level of receptors (estrogen, androgen, glucocorticoid, retinoid) and steroidogenesis. The methods can be used to study important pollutants, as well as agrochemicals, pharmaceuticals or complex mixtures from environmental samples. The project will bring new information on potential of persistent organic pollutants (POPs), which significantly contribute to environmental pollution in the Czech Republic, to affect the endocrine system. The project will be focused on filling gaps in information about commonly studied POPs and on testing new priority POPs. The results will complement ecotoxicological characteristics of studied compounds and contribute to prediction of risks related to contamination. The project will"@en . . "This pos-doc project led to establishment of a wide battery of bioassays for study of specific mechanisms linked to endocrine disruption. These assays were used for the evaluation of endocrine disruptive potential of xenobiotics as well as of complex env"@en . . "endocrine disruption; estrogenity; androgenity; RAR/RXR; steroidogenesis; receptors; POPs"@en .