"bun\u011B\u010Dn\u00E9 kultury, priony, endogenn\u00ED retroviry, propagace a \u0161\u00ED\u0159en\u00ED prion\u016F"@en . "Cell culture for propagation of prions: influence of cell culture proliferation and expression of endogenous retroviruses"@en . . " endogenn\u00ED retroviry" . "The project was excellent, both in terms of expertise and in terms of disbursement of funds."@en . . . " priony" . "2011-04-16+02:00"^^ . . "C\u00EDle: 1.Zji\u0161t\u011Bn\u00ED vn\u00EDmavosti bun\u011B\u010Dn\u00FDch lini\u00ED k infekci PrPtse v z\u00E1vislosti na bun\u011B\u010Dn\u00E9 d\u011Blen\u00ED. 2.Zji\u0161t\u011Bn\u00ED propagace PrPtse v z\u00E1vislosti na bun\u011B\u010Dn\u00E9m d\u011Blen\u00ED a sledov\u00E1n\u00ED mechanismu p\u0159enosu infekce. 3.Sledov\u00E1n\u00ED exprese endogenn\u00EDch retrovir\u016F v bun\u011B\u010Dn\u00FDch lini\u00EDch infikovan\u00FDch r\u016Fzn\u00FDmi kmeny PrPtse." . . . "2011-12-31+01:00"^^ . . "bun\u011B\u010Dn\u00E9 kultury" . "\u0158e\u0161en\u00ED projektu prob\u011Bhlo na vynikaj\u00EDc\u00ED \u00FArovni, a to jak z hlediska odborn\u00E9ho tak i z hlediska \u010Derp\u00E1n\u00ED finan\u010Dn\u00EDch prost\u0159edk\u016F."@cs . . "2015-03-02+01:00"^^ . "6"^^ . "6"^^ . . . "2009-01-01+01:00"^^ . . . "GP310/09/P260" . . "The unifying pathological mechanism of Transmissible spongifom encephalopathies or prion diseases, is the misfolding of cellular prion protein - PrPc into infectious isoform - PrPtse. Little is known about physiological function of PrPc and also processes of conformational changes from PrPc to the PrPtse.Cell lines are convenient experimental systems for analyzing the molecular and cellular mechanisms of prion propagation. Prion propagation in cell culture differs fundamentally from the course of infection in vivo. Conditions in vitro are unique for the study of interplay between de novo prion formation, catabolism, cell division, and horizontal transmission. Although PrPc is essential for the development of prion diseases other factors are thought to be involved in the PrPtse formation and replication. One of these factors could be retroviruses respectively endogenous retroviruses.Investigation of some aspects of cell proliferation for the infection and propagation of prions and significance of expression of endogenous retroviruses in infected cells is aim of the present proposal."@en . "Propagace prion\u016F v bun\u011B\u010Dn\u00FDch kultur\u00E1ch: vliv podm\u00EDnek kultivace bun\u011B\u010Dn\u00FDch lini\u00ED a exprese endogenn\u00EDch retrovir\u016F" . "0"^^ . . "0"^^ . . . "1"^^ . . . "http://www.isvav.cz/projectDetail.do?rowId=GP310/09/P260"^^ .