. . "The project was excellent, both in terms of expertise and in terms of disbursement of funds."@en . "6"^^ . "6"^^ . "Proteinase-activated receptors are essentially ubiquitous receptors activated by certain serine proteinases. This is a family of G-protein coupled receptors activated by subsequent cleavage at the\u00A0specific site of the NH2 terminal and presentation of the\u00A0new terminal, which behaves as %22a\u00A0tethered ligand%22. Neurodegenerative diseases are very serious confirmed diseases which incidence is sharply increasing in relation to the aging of the population. Based on the literature and according to our previous finding we assume that serum proteinases play an important role in the pathophysiology of degenerative diseases of CNS via activation of PAR\u00B4s. We further assume that these processes are closely linked to the blood-brain barrier damage by endogenous or exogenous factors. To observe the role of PAR in degenerative processes of CNS the PAR-2 changes of expressions will be followed and compared to other neurodegenerative markers in animal models. The obtained results will be compared to the observation of the changes of expression of PAR\u00B4s in the model of human samples of neurodegenerative disorders. The human samples will be obtained from the collection of neuropathological material of autoptic CNS tissues affected by different neurodegenerative diseases."@en . "0"^^ . . "1"^^ . "2015-03-02+01:00"^^ . . "\u00DAloha PAR-2 v neurodegenerativn\u00EDch onemocn\u011Bn\u00EDch" . "GP309/09/P204" . "0"^^ . . "PAR-2, neurodegenerace, trypsin"@en . "2009-01-01+01:00"^^ . . . . . . "2011-04-16+02:00"^^ . . . "The role of PAR-2 in neurodegenerative diseases"@en . . " neurodegenerace" . . . . . "2011-12-31+01:00"^^ . "\u0158e\u0161en\u00ED projektu prob\u011Bhlo na vynikaj\u00EDc\u00ED \u00FArovni, a to jak z hlediska odborn\u00E9ho tak i z hlediska \u010Derp\u00E1n\u00ED finan\u010Dn\u00EDch prost\u0159edk\u016F."@cs . . "C\u00EDlem p\u0159edkl\u00E1dan\u00E9ho projektu je zjistit zda a jak\u00FDm zp\u016Fsobem se protein\u00E1zy trypsin a trombin a jejich agonistick\u00E9 molekuly pod\u00EDl\u00ED na patogenezi neurodegenerativn\u00EDch onemocn\u011Bn\u00ED prost\u0159ednictv\u00EDm aktivace PAR\u00B4s." . "PAR-2" . "http://www.isvav.cz/projectDetail.do?rowId=GP309/09/P204"^^ . . .