. "8"^^ . "Narcolepsy with cataplexy is associated with a loss of neuropeptide hypocretin, produced by neurons of the postero-lateral hypothalamus. To answer, if there is an autoimmune or neurodegenerative process selectively killing the hypothalamic hypocretin-con"@en . . "\u00DAloha hypokretinu v patofyziologii prim\u00E1rn\u00EDch dyssomni\u00ED - Imunologick\u00E9 a neurovegetativn\u00ED aspekty. Neuroanatomick\u00E9 korel\u00E1ty" . . "8"^^ . . "Narcolepsy has been thought to be an autoimmune disorder. The finding that hypocretin-containing neurons of the posterior hypothalamus cannot be detected in the brain of HLA DQB1*0602 positive narcoleptic patients suggest that these cells may be aprimarytarget for this process. HLA association studies in patients without cataplexy indicated lower HLA DQB1*0602 association, suggesting disease heterogeneity and/or a direct effect of HLA DQB1*0602 on disease severity and the occurrence ofcataplexy. Prelim inary CSF (cerebro-spinal fluid) hypocretin studies in narcolepsy-cataplexy and HLA DQB1*0602 negative studies have normal CSF levels in most cases, suggesting disease heterogeneity and non-involvement of hypocretin system. Probably, thenarcolepsy may initially involve the destruction of selected hypocretin projections, with resulting sleep abnormalities and often normal CSF hypocretin levels. This pathophysiological mechanism may escalate to a complete destruction in HLA DQB1*0602"@en . . "1"^^ . "Narkolepsie je pova\u017Eov\u00E1na za autoimunitn\u00ED onemocn\u011Bn\u00ED. Na z\u00E1klad\u011B neuropatologick\u00FDch n\u00E1lez\u016F sn\u00ED\u017Een\u00E9ho po\u010Dtu hypokretinov\u00FDch (Hcrt) neuron\u016F v oblasti dorzolater\u00E1ln\u00EDho hypothalamu u HLA DQB1*0602 pozitivn\u00EDch pacient\u016F, lze p\u0159edpokl\u00E1dat, \u017Ee tyto neurony jsouprim\u00E1rn\u00EDm c\u00EDlem autoimunitn\u00EDho procesu. Tento haplotyp m\u00E1 z\u0159ejm\u011B predisponuj\u00EDc\u00ED v\u00FDznam pro vznik onemocn\u011Bn\u00ED. U izolovan\u00E9 narkolepsie tato asociace zji\u0161t\u011Bna nebyla, co\u017E sv\u011Bd\u010D\u00ED pro mo\u017Enou korelaci HLA DQB1*0602 pozitivity s v\u00FDskytem kataplexie, event. sez\u00E1va\u017Enost\u00ED narkolepsie, a pro mo\u017En\u00FD heterogenn\u00ED p\u016Fvod onemocn\u011Bn\u00ED. To potvrzuj\u00ED i zji\u0161t\u011Bn\u00ED norm\u00E1ln\u00EDch hladin Hcrt u HLA DQB1*0602 negativn\u00EDch pacient\u016F s narkolepsi\u00ED-kataplexi\u00ED. Lze se domn\u00EDvat, \u017Ee u narkolepsie inici\u00E1ln\u011B doch\u00E1z\u00ED k destrukci Hcrt projekce,co\u017Erezultuje ve zn\u00E1m\u00E9 abnormity sp\u00E1nku p\u0159i je\u0161t\u011B norm\u00E1ln\u00ED hladin\u011B Hcrt a teprve vystup\u0148ov\u00E1n\u00EDm tohoto procesu m\u016F\u017Ee doj\u00EDt k HLA DQB1*0602 pozitivit\u011B jako korel\u00E1tu z\u00E1va\u017Enosti onemocn\u011Bn\u00ED s nedetekovatelnou hladinou Hcrt a s typickou kataplexi\u00ED. C\u00EDlem t\u00E9to" . "GP309/03/P026" . . . . . "http://www.isvav.cz/projectDetail.do?rowId=GP309/03/P026"^^ . "0"^^ . . "Neuvedeno."@en . . "0"^^ . . . . "Narkolepsie-kataplexie je spojena se sn\u00ED\u017Eenou hladinou hypothalamick\u00E9ho neuropeptidu hypokretinu v\u00A0mozkom\u00ED\u0161n\u00EDm moku. Ve snaze odpov\u011Bd\u011Bt, zda se jedn\u00E1 o autoimunitn\u00ED \u010Di neurodegenerativn\u00ED proces, kter\u00FD selektivn\u011B postihuje bu\u0148ky posterolater\u00E1ln\u00EDho hypotha"@cs . . "The role of the hypocretine in pathophysiology of primary dyssomnias - Immunological and neurovegetative aspects. Neuroanatomical corelates"@en . . . . "2008-05-19+02:00"^^ . .