. . "0"^^ . "Projekt byl ukon\u017Aen po 4 m\u0158s\u02C7c\u02C7ch \u00FDe\u00E7en\u02C7 na \u00A7\u00A0dost \u00FDe\u00E7itele za zdravotn\u02C7ch d\u2026vod\u2026. Z\u00A0v\u0158re\u017An\u00A0 zpr\u00A0va nebyla po\u00A7adov\u00A0na."@cs . "GP309/02/D066" . . . . "http://www.isvav.cz/projectDetail.do?rowId=GP309/02/D066"^^ . . "1"^^ . "Free light chains of immunoglobulins in cerebrospinal fluid, serum and urine in multiple sclerosis"@en . "0"^^ . . . "0"^^ . . "The goals of the project Free light chains of immunoglobulins in cerebrospinal fluid, serum and urine in multiple sclerosis are as follows: 1) to confirm the significance of the determination of free light chains of immunoglobulins (fLC) in cerebrospinalfluid (CSF) in the diagnosis of multiple sclerosis (MS) in a larger series of about 150 patients, 2) to evaluate possible relationships between fLC concentrations in CSF, serum and urine (and, possibly, also the number of fLC bands in CSF) and between a)the results of other CSF tests performed routinely in samples from MS patients, b) clinical parameters, mainly disease activity and degree of disability, 3) to assess the dynamics of fLC concentrations in the above mentioned biological fluids (and, possibly, also of oligoclonal fLC pattern in CSF) in individual MS patients according to their clinical status, MRI findings, and treatment, especially in patients before/after autologous hematopoietic stem cell transplantation, 4) to improve both"@en . "C\u02C7lem projektu Voln\u201A lehk\u201A \u00FDet\u0158zce imunoglobulin\u2026 v\u02D9likvoru, s\u201Aru a mo\u017Ai u roztrou\u00E7en\u201A skler\u02D8zy je 1) ov\u0158\u00FDit na rozs\u00A0hlej\u00E7\u02C7m souboru cca 150 pacient\u2026 v\u011Bznam stanoven\u02C7 voln\u011Bch lehk\u011Bch \u00FDet\u0158zc\u2026 imunoglobulin\u2026 (fLC) v\u02D9likvoru v\u02D9diagnostice roztrou\u00E7en\u201A skler\u02D8zy (RS), 2) vysledovat vztahy mezi koncentracemi fLC v\u02D9likvoru, s\u201Aru a mo\u017Ai (p\u00FD\u02C7padn\u0158 t\u201A\u00A7 po\u017Atem oligoklon\u00A0ln\u02C7ch fLC p\u00A0s\u2026 v\u02D9likvoru) a a) v\u011Bsledky ostatn\u02C7ch vy\u00E7et\u00FDen\u02C7 likvoru b\u0158\u00A7n\u0158 prov\u00A0d\u0158n\u011Bch u pacient\u2026 s\u02D9RS, b) klinick\u011Bmi parametry, zejm\u201Ana aktivitou onemocn\u0158n\u02C7 a t\u02C7\u00A7\u02C7 posti\u00A7en\u02C7, 3) sledovat dynamiku koncentrac\u02C7 fLC (p\u00FD\u02C7padn\u0158 t\u201A\u00A7 oligoklon\u00A0ln\u02C7ho vzorce fLC v\u02D9likvoru) u jednotliv\u011Bch pacient\u2026 v\u02D9z\u00A0vislosti na klinick\u201Am stavu, MRI n\u00A0lezu a pou\u00A7it\u201A l\u201A\u017Ab\u0158, p\u00FDedev\u00E7\u02C7m u pacient\u2026 p\u00FDed/po transplantacautologn\u02C7ch hematopoetick\u011Bch kmenov\u011Bch bun\u0158k, 4) pr\u2026b\u0158\u00A7n\u0158 zdokonalovat kvantitativn\u02C7 i kvalitativn\u02C7 metody vy\u00E7et\u00FDen\u02C7 fLC, zejm\u201Ana zv\u011B\u00E7it senzitivitu pr\u2026kazu fLC metodou izoelektrick\u201A fokusace s\u02D9n\u00A0sledn\u011Bm imunoblottingem, aby bylo mo\u00A7n\u201A posoudit %22norm\u00A0ln\u02C7" . "Neuvedeno."@en . . . "2009-06-15+02:00"^^ . "Voln\u201A lehk\u201A \u00FDet\u0158zce imunoglobulin\u2026 v likvoru, s\u201Aru a mo\u017Ai u roztrou\u00E7en\u201A skler\u02D8zy" . . . . . . . . "0"^^ .