"renin-angiotensin-aldosteron system; salt-sensitive hypertension; renin transgenic rats"@en . "0"^^ . . . . . "1"^^ . "2015-03-20+01:00"^^ . . . "This study evaluated the effects of increasing dietary salt loading and of salt restriction on blood pressure (BP) and the renin-angiotensin-aldosterone system in Cyp1a1-Ren-2 transgenic rats with inducible hypertension. Hypertension was induced through dietary administration of xenobiotic indole-3-carbinol (I3C; 0.3%). Rats were fed either a normal salt (NS) or high salt (HS; 2, 4 and 8% NaCl) o"@en . "9"^^ . . . . . "9"^^ . . . . . . "2010-12-31+01:00"^^ . " salt-sensitive hypertension" . "Sou\u010Dasn\u00E9 studie poukazuj\u00ED na d\u016Fle\u017Eitou roli renin-angiotenzin-aldosteronov\u00E9ho syst\u00E9mu (RAAS) v rozvoji s\u016Fl-senzitivn\u00ED formy hypertenze. P\u0159edkl\u00E1dan\u00E1 studie by se m\u011Bla zab\u00FDvat ot\u00E1zkou, zda citlivost na s\u016Fl je v\u00FDsledkem zv\u00FD\u0161en\u00FDch hladin angiotenzinu II (ANGII) a aldosteronu jako n\u00E1sledek zv\u00FD\u0161en\u00E9 aktivity RAAS nebo je v\u00FDsledkem neschopnosti p\u0159im\u011B\u0159en\u011B sn\u00ED\u017Eit hladiny cirkuluj\u00EDc\u00EDho a tk\u00E1\u0148ov\u00E9ho ANG II i aldosteronu v reakci na zv\u00FD\u0161en\u00FD p\u0159\u00EDsun soli v diet\u011B. Ned\u00E1vno byl vytvo\u0159en unik\u00E1tn\u00ED model renin transgenn\u00EDch potkan\u016F s indukovatelnou hypertenz\u00ED, kter\u00FD exprimuje my\u0161\u00ED Ren-2 reninov\u00FD gen pod kontrolou Cyp1a1 promotoru. Tento model umo\u017E\u0148uje navozen\u00ED hypertenze\u00A0s fixn\u011B\u00A0zv\u00FD\u0161en\u00FDmi hladinami plazmatick\u00E9ho reninu, ANG II i aldosteronu, kter\u00E9 nepodl\u00E9haj\u00ED b\u011B\u017En\u00FDm fyziologick\u00FDm mechanism\u016Fm zp\u011Btn\u00E9 vazby reguluj\u00EDc\u00EDch aktivitu RAAS. Tento model transgenn\u00EDch potkan\u016F n\u00E1m umo\u017E\u0148uje\u00A0zjistit \u00FAlohu zhor\u0161en\u00FDch fyziologick\u00FDch regulac\u00ED RAAS\u00A0p\u0159i\u00A0reakci na zm\u011Bny v p\u0159\u00EDsunu soli v patofyziologii s\u016Fl-senzitivn\u00ED hypertenze." . . . "Contribution of the RAAS to the pathophysiology of salt-sensitive hypertension: a study in renin transgenic rats with inducible hypertension"@en . "Recent studies have implicated an important role of the renin-angiotensin-aldosterone system (RAAS) in the development of salt-sensitive hypertension. This study should address the issue whether the salt sensitivity is the result of increased angiotensinII (ANG II) and aldosterone levels as the consequence of enhanced activity of the RAAS or the result of the inability to appropriately down-regulate circulating and tissue ANG II and aldosterone levels to increased dietary salt intake.\u00A0A unique model of renin transgenic rats with inducible hypertension, which express the mouse Ren-2 renin gene under the control of the Cyp1a1 promoters has been generated. This model allows induction of hypertension with fixed elevated plasma renin, ANG II and aldosteronelevels that are not subjected to the normal physiological feedback mechanisms regulating the activity of the RAAS. This transgenic rat model allows assessment of contribution of the impairment of physiological regulation of the RAAS in response to"@en . . "GP305/08/P053" . "\u00DAloha RAAS v patofyziologii s\u016Fl-senzitivn\u00ED hypertenze: studie na renin transgenn\u00EDch potkanech s indukovatelnou hypertenz\u00ED" . "2010-04-16+02:00"^^ . "0"^^ . "renin-angiotensin-aldosteron system" . "Tato studie se zab\u00FDv\u00E1 \u00FA\u010Dinkem vysok\u00E9ho a sn\u00ED\u017Een\u00E9ho dietn\u00EDho p\u0159\u00EDjmu soli na v\u00FD\u0161i krevn\u00EDho tlaku (TK) a na vlastn\u00ED renin-angiotenzin-aldosteronov\u00FD syst\u00E9m u Cyp1a1-Ren-2 transgenn\u00EDch potkan\u016F s indukovatelnou hypertenz\u00ED. Hypertenze byla navozena pod\u00E1v\u00E1n\u00EDm indole-3-carbinolu (I3C; 0,3%) v diet\u011B. Zv\u00ED\u0159ata byla krmena dietou s norm\u00E1ln\u00EDm, vysok\u00FDm (2, 4 a 8 %) nebo n\u00EDzk\u00FDm (0,01% NaCl) obsahem sol"@cs . "2008-01-01+01:00"^^ . "http://www.isvav.cz/projectDetail.do?rowId=GP305/08/P053"^^ .