"0"^^ . . "http://www.isvav.cz/projectDetail.do?rowId=GP303/09/P049"^^ . "2011-12-31+01:00"^^ . "1"^^ . "The project was excellent, both in terms of expertise and in terms of disbursement of funds."@en . "Alzheimerova choroba" . . "3"^^ . . . . "0"^^ . "3"^^ . "\u0158e\u0161en\u00ED projektu prob\u011Bhlo na vynikaj\u00EDc\u00ED \u00FArovni, a to jak z hlediska odborn\u00E9ho tak i z hlediska \u010Derp\u00E1n\u00ED finan\u010Dn\u00EDch prost\u0159edk\u016F."@cs . "The study of the products of free radicals in erythrocytes as possible markers of Alzheimer disease"@en . . . "Studium vyu\u017Eit\u00ED produkt\u016F radik\u00E1lov\u00FDch reakc\u00ED v erytrocytech jako potenci\u00E1ln\u00EDch marker\u016F Alzheimerovy choroby" . . . "Alzheimer disease (AD) is the most common form of dementia. Free radicals play an important role in the pathogenesis. Even if\u00A0 the source of increased free radical production is still unclear, the toxic effect of amyloid\u00A0 \u00DF (A\u00DF) has been discussed. Ab is formed from the membrane-bound precursor. In AD patients Ab-amyloidosis has been found in senile plaques and in the brain blood vessels and is accompanied with an increased free radical production. Erythrocytes in the brain blood vessels interact with A\u00DF and can bind it. Free radicals initiate the lipid peroxidation process in the erythrocyte memrane leading to the production of peroxidation products, lipofuscin like pigments (LFP). The fluorescent characteristics of these pigments differ in various pathologies. In our previous study we have confirmed the presence of the specific LFP in erythrocytes of demented dogs that are used as a model for AD. In this project we will characterize the fluorescent products in erythrocyte membranes of AD patients. We shall investigate the specific products that could be used for the diagnosis."@en . "2009-01-01+01:00"^^ . . "Alzheimerova choroba, oxida\u010Dn\u00ED stres, lipofuscinoidn\u00ED pigmenty, erytrocyty, diagnostick\u00E9 markery"@en . "2011-04-16+02:00"^^ . " lipofuscinoidn\u00ED pigmenty" . " oxida\u010Dn\u00ED stres" . "GP303/09/P049" . . . . . "2015-03-02+01:00"^^ . . . . " erytrocyty" . . . "Pomoc\u00ED fluorescen\u010Dn\u00ED anal\u00FDzy peroxida\u010Dn\u00EDch produkt\u016F v membr\u00E1n\u00E1ch erytrocyt\u016F naj\u00EDt specifick\u00E9 produkty doprov\u00E1zej\u00EDc\u00ED oxida\u010Dn\u00ED stres u Alzheimerovy choroby. Detekce t\u011Bchto produkt\u016F m\u016F\u017Ee b\u00FDt vyu\u017Eita k diagn\u00F3ze a ke sledov\u00E1n\u00ED pr\u016Fb\u011Bhu l\u00E9\u010Dby Alzheimerovy choroby." .