"0"^^ . "Existuj\u00ED opr\u00E1vn\u011Bn\u00E9 p\u0159edpoklady, \u017Ee se p\u0159i rozvoji diabetick\u00FDch mikrovaskul\u00E1rn\u00EDch komplikac\u00ED (zejm\u00E9na diabetick\u00E9 nefropatie) uplat\u0148uje individu\u00E1ln\u00ED geneticky modifikovan\u00E1 predispozice. Vzhledem k jednozna\u010Dn\u00E9 roli hyperglyk\u00E9mi\u00ED-indukovan\u00E9 glykoxidace v pat"@cs . . . . . "15"^^ . . "15"^^ . . . . . "GP303/02/D127" . "http://www.isvav.cz/projectDetail.do?rowId=GP303/02/D127"^^ . . "Development of the late diabetic complications is closely related to the duration and metabolic compensation of the disease. Nevertheless, a considerable interindividual variability in the development, progression and clinical extent of the latecomplications is observed among diabetics. Part of this variability could be ascribed to genetic factors. Considering the apparent role of glycoxidation in the pathogenesis of diabetic complications, genes encoding antioxidant enzymes modulating theoverall level of oxidant stress seem to be logical candidates. Less functional variants decreasing antioxidant capacity could act pathologically during the long period of hyperglycemia-driven enhanced formation of reactive oxygen species in diabetes. Theaim of the study is to examine possible associations between genetic polymorphisms in genes encoding antioxidant enzymes and other related substances (paraoxonase, NAD(P)H: quinon oxidoreductase, glyoxalase and HFE protein) and the extent of diabetic"@en . . "Relationship between genetic variability of antioxidant system and late complications of diabetes mellitus"@en . "0"^^ . . . "Vztah genetick\u00E9 variability antioxida\u010Dn\u00EDho syst\u00E9mu k pozdn\u00EDm komplikac\u00EDm diabetu mellitu" . . . "1"^^ . "Rozvoj pozdn\u00EDch komplikac\u00ED diabetu mellitu je v\u00A0\u00FAzk\u00E9m vztahu k\u00A0trv\u00E1n\u00ED a metabolick\u00E9 kompenzaci onemocn\u011Bn\u00ED. P\u0159esto pozorujeme v\u00A0rychlosti n\u00E1stupu a progrese i v\u00A0celkov\u00E9 m\u00ED\u0159e posti\u017Een\u00ED pozdn\u00EDmi komplikacemi mezi diabetiky zna\u010Dnou interindividu\u00E1ln\u00EDvariabilitu. \u010C\u00E1st t\u00E9to variability by mohla b\u00FDt podm\u00EDn\u011Bna geneticky. Vzhledem ke z\u0159ejm\u00E9 roli glykoxidace v\u00A0patogenezi diabetick\u00FDch komplikac\u00ED jsou potenci\u00E1ln\u00EDmi kandid\u00E1tn\u00EDmi geny mimo jin\u00E9 tak\u00E9 ty, kter\u00E9 k\u00F3duj\u00ED antioxida\u010Dn\u00ED enzymy moduluj\u00EDc\u00ED celkovou\u00FArove\u0148 oxida\u010Dn\u00EDho stresu. V\u00A0podm\u00EDnk\u00E1ch diabetu, kdy je v\u00A0d\u016Fsledku hyperglyk\u00E9mie mohutn\u011B zv\u00FD\u0161ena tvorba voln\u00FDch kysl\u00EDkov\u00FDch radik\u00E1l\u016F, se mohou n\u011Bkter\u00E9 m\u00E9n\u011B funk\u010Dn\u00ED varianty uplatnit jako patologick\u00E9, proto\u017Ee sni\u017Euj\u00ED schopnost vyrovnat se se zv\u00FD\u0161enouoxida\u010Dn\u00ED z\u00E1t\u011B\u017E\u00ED. C\u00EDlem projektu je studium asociace vybran\u00FDch polymorfn\u00EDch variant v\u00A0genech k\u00F3duj\u00EDc\u00EDch antioxida\u010Dn\u00ED enzymy a proteiny \u00FA\u010Dastn\u00EDc\u00ED se na modulaci oxida\u010Dn\u00EDho stresu (paraoxon\u00E1za, NAD(P)H: quinon oxidoredukt\u00E1za, glyoxal\u00E1za a HFE protein)" . . . "Neuvedeno."@en . . . "Existence of genetic predisposition modifying individual susceptibility to the development of diabetic microvascular complications (namely diabetic nephropathy) is strongly suggested. Considering the apparent role of hyperglycaemia-induced glycoxidation"@en . . "2008-07-23+02:00"^^ .