. . "1"^^ . . . "The project was excellent, both in terms of expertise and in terms of disbursement of funds."@en . . . . . "2011-12-31+01:00"^^ . . "MDS" . . . . "2011-04-16+02:00"^^ . . . "Importance of miRNA deregulation in myelodysplastic syndromes and in other hematological clonal diseases"@en . . " microarray" . "GP301/09/P579" . "\u0158e\u0161en\u00ED projektu prob\u011Bhlo na vynikaj\u00EDc\u00ED \u00FArovni, a to jak z hlediska odborn\u00E9ho tak i z hlediska \u010Derp\u00E1n\u00ED finan\u010Dn\u00EDch prost\u0159edk\u016F."@cs . "0"^^ . . "V r\u00E1mci projektu budou studov\u00E1ny zm\u011Bny v expresi miRNA pro r\u016Fzn\u00E1 st\u00E1dia MDS a dal\u0161\u00ED hematologick\u00E1 onemocn\u011Bn\u00ED. Pokud budou nalezeny miRNA, jejich\u017E deregulace bude u MDS v\u00FDznamn\u00E1, budou stanoveny hladiny exprese jejich c\u00EDlov\u00FDch gen\u016F se snahou pochopit \u00FA\u010Dinek t\u011Bchto miRNA na rozvoj onemocn\u011Bn\u00ED." . . . "0"^^ . "4"^^ . "V\u00FDznam deregulace microRNA u myelodysplastick\u00E9ho syndromu a dal\u0161\u00EDch hematologick\u00FDch klon\u00E1ln\u00EDch onemocn\u011Bn\u00ED" . "2015-03-02+01:00"^^ . "http://www.isvav.cz/projectDetail.do?rowId=GP301/09/P579"^^ . "2009-01-01+01:00"^^ . "4"^^ . "MDS; microarray; miRNA"@en . "Myelodysplasic syndrome (MDS) is a family of heterogeneous blood disorders that originate in a pluripotent stem cell. They are considered a preleukemic condition. An intensive research has been focused on MDS pathogenesis and cytogenetic aberrations associated with approx. 50% of MDS have been revealed; however, reasons for MDS progression remain unknown. To date, genes responsible for MDS has not been identified and it is uncertain whether chromosomal aberrations are the primary reason or a secondary event. microRNAs (miRNAs), components of the RNA interference mechanism, play key roles in many cell processes incl. hematopoiesis. miRNA deregulation is responsible for cell transformation in a variety of tumors and leukemia; however, miRNA importance in MDS has not been investigated yet. By expression analysis, we want to identify miRNAs deregulated in MDS and monitor changes in miRNA expression profile in different MDS stages. We want to correlate deregulated miRNA levels to amounts of their target gene expression products and reveal impacts of miRNA deregulation on MDS progression."@en .