. "Genetic risk prediction to sepsis in children"@en . . . "http://www.isvav.cz/projectDetail.do?rowId=GP301/03/D196"^^ . . "GP301/03/D196" . "0"^^ . "Polymorfismus gen\u016F k\u00F3duj\u00EDc\u00EDch proteinov\u00E9 receptory na bu\u0148k\u00E1ch imunitn\u00EDho syst\u00E9mu hraje v\u00FDznamnou roli p\u0159i p\u0159ekon\u00E1v\u00E1n\u00ED septick\u00FDch stav\u016F. Mezi nejd\u016Fle\u017Eit\u011Bj\u0161\u00ED pat\u0159\u00ED lipopolysacharidy v\u00E1zaj\u00EDc\u00ED protein (lipopolysacharide binding protein - LBP), baktericidn\u00ED/permeabilitu zvy\u0161uj\u00EDc\u00ED protein (bactericidal permeability increasing protein - BPI), toll-like receptory (TLR) a tumory nekrotizuj\u00EDc\u00ED faktor beta (tumor necrosis factor -TNF beta). V\u00A0sou\u010Dasn\u00E9 dob\u011B bylo prok\u00E1z\u00E1no, \u017Ee n\u011Bkter\u00E9 varianty t\u011Bchto gen\u016F jsou spojeny s\u00A0nep\u0159\u00EDzniv\u00FDm v\u00FDvojem infekce a \u010Dasto vedou k\u00A0rozvoji septick\u00E9ho stavu, multiorg\u00E1nov\u00E9mu selh\u00E1n\u00ED a smrti pacienta. C\u00EDlem t\u00E9to studie je geneticky zmapovat polymorfismus t\u011Bchto gen\u016F a p\u0159\u00EDpadn\u011B objevit jejich kombinace predisponuj\u00EDc\u00ED k\u00A0t\u011B\u017Ek\u00E9mu septick\u00E9mu stavu u d\u011Bt\u00ED hospitalizovan\u00FDch ve Fakultn\u00ED nemocnici Brno. T\u00EDmto zp\u016Fsobem bude mo\u017En\u00E9 predikovat septick\u00FD stav u rizikov\u00FDch pacient\u016F a v\u010Das u nich zah\u00E1jit efektivn\u00ED l\u00E9\u010Debn\u011B-preventivn\u00ED opat\u0159en\u00ED." . . . "The polymorphism of genes encoding protein receptors on immune system cells plays an important role in surviving sepsis. Some of the most important are lipopolysacharide binding protein (LBP Cys98Gly and LBP Pro436Leu), bactericidal permeability increasi"@en . "Genetick\u00E1 predikce rizika septick\u00E9ho stavu u d\u011Btsk\u00FDch pacient\u016F" . "2007-10-16+02:00"^^ . "1"^^ . "V\u00FDzkumn\u00FD projekt se zab\u00FDval studiem celkem 7 polymorfism\u016F 4 gen\u016F k\u00F3duj\u00EDc\u00EDch proteinov\u00E9 receptory na bu\u0148k\u00E1ch imunitn\u00EDho syst\u00E9mu, kter\u00E9 hraj\u00ED v\u00FDznamnou roli p\u0159i p\u0159ekon\u00E1v\u00E1n\u00ED septick\u00FDch stav\u016F u d\u011Btsk\u00FDch pacient\u016F. Jednalo se o polymorfismy genu pro lipopolysa"@cs . "The polymorphism of genes encoding protein receptors on immune system cells plays an important role in surviving sepsis. Some of the most important are lipopolysacharide binding protein (LBP), bactericidal permeability increasing protein (BPI), toll-likereceptors (TLR) and tumor necrosis factor beta (TNF beta). It has been demonstrated recently that some variants of these genes are frequently associated with severe infections, development of sepsis, multiorgan failure and death. The aim of this study isto map the polymorphism of these genes and eventually find the combinations predisposing to severe sepsis in children hospitalized at the University Hospital Brno. This approach may lead to prediction of high-risk patients with sepsis so the effective treatment can be started early."@en . "3"^^ . . "0"^^ . . "3"^^ . . . . . "Neuvedeno."@en . . . . . . . . .