"http://www.isvav.cz/projectDetail.do?rowId=GP204/09/P155"^^ . "2015-03-02+01:00"^^ . "Aurora kin\u00E1za" . . . "\u0158e\u0161en\u00ED projektu prob\u011Bhlo podle pl\u00E1nu jak z hlediska odborn\u00E9ho tak i z hlediska \u010Derp\u00E1n\u00ED finan\u010Dn\u00EDch prost\u0159edk\u016F."@cs . . "2011-04-16+02:00"^^ . "GP204/09/P155" . . "Charakterizace homolog\u016F Aurora kin\u00E1z a jejich role v pr\u016Fb\u011Bhu organizace acentrozom\u00E1ln\u00EDho v\u0159et\u00E9nka a cytokineze. Objasn\u011Bn\u00ED, zda interakce Aurora kin\u00E1z s RanGTP dr\u00E1hami pod\u00EDlej\u00EDc\u00EDmi se na nukleaci mikrotubul\u016F, kter\u00E9 jsou zn\u00E1m\u00E9 u \u017Eivo\u010Dich\u016F, existuj\u00ED i u acentrozom\u00E1ln\u00EDch rostlinn\u00FDch bun\u011Bk." . . "0"^^ . . . "Aurora kin\u00E1za; Arabidopsis; bun\u011B\u010Dn\u00FD cyklus; cytoskelet"@en . "2009-01-01+01:00"^^ . "1"^^ . . "2011-12-31+01:00"^^ . " Arabidopsis" . "The project gone according to plan both in terms of expertise and in terms of disbursement of funds."@en . . "3"^^ . "0"^^ . " bun\u011B\u010Dn\u00FD cyklus" . "3"^^ . . . . "Aurora kinases and their role in cell division of acentrosomal plant cells"@en . . . . . . "The Aurora kinase family presents a serine/threonine protein kinases that regulate different processes of mitosis and meiosis and interact with microtubule organization machinery. The Aurora kinases as a crutial players in cell proliferation are over expressed in a variety of cancers. Although function of animal and yeast Aurora kinases have been analyzed, plant Aurora kinases are much less characterized. Proposed project is focused on study of plant Aurora kinases specifically Aur1 and Aur3. We will study effect of Aurora kinase on microtubule nucleation and organization in vivo using transient and stable co-expression of GFP kinases with gamma-tubulin, microtubules or Ran GTPases. Aurora kinases ineracting proteins will be isolated from wild type or transformed cultures expressing tagged versions of kinases. Downregulation of Arabidopsis Aurora1 and 3 by RNAi will help to understand their role in microtubular organization and cell division in acentrosomal plant cells."@en . . "Studium role Aurora kin\u00E1z u acentrozom\u00E1ln\u00EDch bun\u011Bk vy\u0161\u0161\u00EDch rostlin" . . .