. . . "GP204/02/D129" . "2008-07-23+02:00"^^ . "Neuvedeno."@en . "C\u00EDlem projektu bylo p\u0159isp\u011Bt k \u0159e\u0161en\u00ED jednoho z aktu\u00E1ln\u00EDch probl\u00E9m\u016F biofyziky elektrick\u00FDch jev\u016F u srde\u010Dn\u00EDch komorov\u00FDch bun\u011Bk, tj. k objasn\u011Bn\u00ED vlivu transvers\u00E1ln\u011B-axi\u00E1ln\u00EDho tubul\u00E1rn\u00EDho syst\u00E9mu (TAT-syst\u00E9mu) na bun\u011B\u010Dnou elektrickou aktivitu a vazbu excitace"@cs . . "0"^^ . . . . . . "1"^^ . "Kvantitativn\u00ED anal\u00FDza vlivu tubul\u00E1rn\u00EDho syst\u00E9mu na elektrickou aktivitu srde\u010Dn\u00EDch bun\u011Bk" . . . . "The project was aimed to clarify the role of transverse-axial tubular system (TAT-system) in the processes underlying electrical activity and excitation-contraction coupling which is one of the actual questions of cardiac cellular electrophysiology. With"@en . "The project is a contribution to the solution of one of the major problems of cellular biophysics of electrical phenomena in cardiac cells. As follows from recent experimental work in cardiac ventricular cells, ionic channels are distributed differentlybetween the fine transverse-axial tubular system (TAT-system) and the peripheral membrane. In addition, the accumulation and/or depletion of ions in the TAT- system (during trains of excitations) may significantly affect the excitation-contractioncoupling in mammalian ventricular cells. However, quantitative models used for simulation of action potentials in cardiac cells so far did not include a description of electrical activity of the tubular membrane. The aim of this project is to supplementthe present conception of quantitative models of ventricular action potentials with a quantitative description of electrical activity of tubular membrane. The design of TAT-system models includes systems of partial differential equations and simplified"@en . . . "0"^^ . . "Quantitative analysis of effect of tubular system on electrical activity of cardiac cells"@en . . "17"^^ . "http://www.isvav.cz/projectDetail.do?rowId=GP204/02/D129"^^ . . "Projekt je p\u0159\u00EDsp\u011Bvkem k\u00A0\u0159e\u0161en\u00ED jednoho z\u00A0aktu\u00E1ln\u00EDch probl\u00E9m\u016F biofyziky elektrick\u00FDch jev\u016F u srde\u010Dn\u00EDch bun\u011Bk. V\u00A0sou\u010Dasn\u00E9 dob\u011B ji\u017E existuje uspokojiv\u00FD kvantitativn\u00ED popis elektrick\u00E9 aktivity srde\u010Dn\u00EDch bun\u011Bk soustavami neline\u00E1rn\u00EDch diferenci\u00E1ln\u00EDch rovnic,kter\u00FD se v\u0161ak omezuje jen na povrchovou membr\u00E1nu. Experiment\u00E1ln\u00ED \u00FAdaje posledn\u00EDch let z\u0159eteln\u011B ukazuj\u00ED, \u017Ee v\u00A0membr\u00E1n\u00E1ch tubul\u00E1rn\u00EDho syst\u00E9mu (T-syst\u00E9mu), kter\u00FDm se vzruch \u0161\u00ED\u0159\u00ED do nitra bu\u0148ky, je rozlo\u017Een\u00ED iontov\u00FDch kan\u00E1l\u016F podstatn\u011B odli\u0161n\u00E9 od rozlo\u017Een\u00EDv\u00A0povrchov\u00E9 membr\u00E1n\u011B. Krom\u011B toho lze uvnit\u0159 T-tubul\u016F vzhledem k\u00A0jejich rozm\u011Br\u016Fm p\u0159edpokl\u00E1dat podstatn\u00E9 zm\u011Bny v\u00A0koncentraci jednotliv\u00FDch propustn\u00FDch iont\u016F vyvolan\u00E9 sledem excitac\u00ED. Kvantitativn\u00ED popis elektrick\u00FDch d\u011Bj\u016F na T-syst\u00E9mu v\u0161ak doposud chyb\u00ED.C\u00EDlem projektu je roz\u0161\u00ED\u0159it sou\u010Dasn\u00FD popis elektrick\u00FDch d\u011Bj\u016F na srde\u010Dn\u00EDch bu\u0148k\u00E1ch tak, aby zahrnoval i funkci T-syst\u00E9mu. \u0158e\u0161en\u00ED zahrnuje sestaven\u00ED parci\u00E1ln\u00EDch diferenci\u00E1ln\u00EDch rovnic pro \u0161\u00ED\u0159en\u00ED vzruchu T-tubuly, ve zjednodu\u0161en\u00ED pak sestaven\u00ED syst\u00E9mu" . . "17"^^ . .