"nucleophilic fluoroalkylation; fluorinated compounds; organo-phosphorus compounds"@en . "12"^^ . "http://www.isvav.cz/projectDetail.do?rowId=GP203/08/P310"^^ . . "GP203/08/P310" . "12"^^ . " fluorinated compounds" . "1"^^ . . "2010-04-16+02:00"^^ . "nucleophilic fluoroalkylation" . "Nukleofiln\u00ED zaveden\u00ED fluorovan\u00FDch funk\u010Dn\u00EDch skupin pomoc\u00ED organofosforov\u00FDch slou\u010Denin" . "Byla systematicky zkoum\u00E1na reaktivita fluorovan\u00FDch fosfon\u00E1t\u016F a bylo vyvinuto n\u011Bkolik nov\u00FDch metodologi\u00ED nukleofiln\u00EDch fluoralkyla\u010Dn\u00EDch reakc\u00ED pomoc\u00ED organofosforn\u00FDch slou\u010Denin. Diethyl trifluormethylfosfon\u00E1t byl vyvinut jako reagent pro nukleofiln\u00ED trifluormethylaci a p\u0159\u00EDpravu trifluormethylovan\u00FDch alkohol\u016F, fosf\u00E1t\u016F, sulfid\u016F a selenid\u016F. Diethyl difluormethylfosfon\u00E1t slou\u017E\u00ED jako v\u00FDchoz\u00ED l\u00E1tka k"@cs . "2010-12-31+01:00"^^ . . . . "2015-03-20+01:00"^^ . "0"^^ . . . "0"^^ . "2008-01-01+01:00"^^ . . . . . "In summary, the reactivity of fluorinated phosphonates has been systematically explored and number of new nucleophilic fluoroalkylation methodologies using organo\u2013phosphorus compounds have been developed. Diethyl trifluoromethylphosphonate was developed as a new nucleophilic trifluoromethylating reagent for the synthesis of trifluoromethylated alcohols, phosphates, sulfides and selenides. Diet"@en . . "The grant proposal is focused on the investigation of\u00A0fluorinated phosphonates such as diethyl trifluoromethyl phosphonate, diethyl difluoromethyl phosphonate and tetraethyl fluoromethylenediphosphonate for the nucleophilic introduction of fluorinated groups. This methodology will allow access to compounds containing trifluoromethyl (-CF3), difluoromethyl (-CHF2), difluoromethylene (-CF2-) and fluoromethyl (-CH2F, -CHF-, -CF=) groups, important structural motives in the design of modern biologically active compounds and functional materials."@en . . . . . . "Tento grantov\u00FD n\u00E1vrh se zam\u011B\u0159uje na v\u00FDzkum fluorovan\u00FDch fosfon\u00E1t\u016F jako nap\u0159. diethyl trifluoromethyl fosfon\u00E1tu, diethyl difluoromethyl fosfon\u00E1tu a tetraethyl fluoromethyl\u00E9ndifosfon\u00E1tu pro nukleofiln\u00ED zaveden\u00ED fluorovan\u00FDch funk\u010Dn\u00EDch skupin. Tato metodologie umo\u017En\u00ED p\u0159\u00EDpravu l\u00E1tek obsahuj\u00EDc\u00EDch trifluoromethyl (-CF3), difluoromethyl (-CHF2), difluoromethyl\u00E9n (-CF2-) a fluoromethyl (-CH2F, -CHF-, -CF=) skupiny. Tyto slou\u010Deniny jsou d\u016Fle\u017Eit\u00E9 p\u0159i designu modern\u00EDch biologicky aktivn\u00EDch l\u00E1tek a" . "Nucleophilic introduction of fluorinated groups using organo-phosphorus compounds"@en . .