. "Modified oligonucleotides containing the 3\u00B4-O-P-CH(R)-5\u00B4\u00B4 internucleotide linkages derived from 5\u00B4-substituted nucleoside 5\u00B4-C-phosphonates in the project, and their physico-chemical properties will be studied and the influence of 5\u00B4-substitution on hybridization properties will be investigated. Thermodynamic stabilities of complexes of prepared oligonucleotides with natural complementary counterparts will be evaluated as well as stability of modified oligonucleotides towards nucleolytic enzymes. The project also includes (i) the elaboration of synthetic approaches to novel types of 4\u00B4- and 5\u00B4-substituted 5\u00B4-C-phosphonate analogues which will be tested, as a small molecules, for their ability of acting as cytostatic and/or virostatic agents and (ii) synthesis of epimeric pure 4\u00B4-and 5\u00B4-substituted 5\u00B4-C-phosphonate monomers for oligoadenylates (trimers and tetramers) as potential activators of ribonuclease L."@en . . . "V r\u00E1mci projektu budou p\u0159ipraveny modifikovan\u00E9 oligonukleotidy obsahuj\u00EDc\u00ED 3\u00B4-O-P-CH(R)-5\u00B4\u00B4 internukleotidov\u00E9 vazby odvozen\u00E9 od 5\u00B4-substituovan\u00FDch nukleosid-5\u00B4-C-fosfon\u00E1t\u016F, budou ur\u010Deny jejich chemick\u00E9 a fyzik\u00E1ln\u00ED vlastnosti a prok\u00E1z\u00E1n vliv 5\u00B4-substituce na hybridiza\u010Dn\u00ED vlastnosti oligonukleotid\u016F. Bude zji\u0161t\u011Bna p\u0159edev\u0161\u00EDm termodynamick\u00E1 stabilita komplex\u016F z\u00EDskan\u00FDch oligonukleotid\u016F s p\u0159irozen\u00FDmi komplement\u00E1rn\u00EDmi \u0159et\u011Bzci a stabilita t\u011Bchto oligonukleotid\u016F v\u016F\u010Di nukleolytick\u00FDm enzym\u016Fm. Projekt tak\u00E9 zahrnuje (i) vypracov\u00E1n\u00ED syntetick\u00FDch p\u0159\u00EDstup\u016F k nov\u00FDm typ\u016Fm 4\u00B4-a 5\u00B4-substituovan\u00FDch 5\u00B4-C-fosfon\u00E1tov\u00FDch analog\u016F nukleotid\u016F, kter\u00E9 budou testov\u00E1ny na cytostatick\u00E9 a virostatick\u00E9 \u00FA\u010Dinky ve spolupr\u00E1ci se zahrani\u010Dn\u00EDmi pracovi\u0161ti a (ii) synt\u00E9zu epimern\u011B \u010Dist\u00FDch 4\u00B4- a 5\u00B4-substituovan\u00FDch 5\u00B4-C-fosfon\u00E1tov\u00FDch monomern\u00EDch jednotek pro oligonukleotidovou synt\u00E9zu. Vybran\u00E9 adeninov\u00E9 fosfon\u00E1ty v ribo\u0159ad\u011B budou vyu\u017Eity ke konstukci 2\u00B4-5\u00B4oligoadenyl\u00E1t\u016F (trimer\u016F a tetramer\u016F) jako potenci\u00E1ln\u00EDch aktiv\u00E1tor\u016F ribonukleasy L." . . "http://www.isvav.cz/projectDetail.do?rowId=GP203/04/P273"^^ . "Byly vypracov\u00E1ny syntetick\u00E9 p\u0159\u00EDstupy k nov\u00FDm epimern\u011B \u010Dist\u00FDm monomern\u00EDm jednotk\u00E1m 2'-deoxynukleosid-5'-C-fosfon\u00E1t\u016Fm odvozen\u00FDch od nukleobaz\u00ED T, CBz, ABz, GDBAM. D\u00E1le byly p\u0159ipraveny nov\u00E9 4\u00B4- a 5\u00B4-substituovan\u00E9 5\u00B4-C-fosfon\u00E1tov\u00E9 analogy nukleotid\u016F, t.j. 4\u00B4"@cs . . "0"^^ . . . . "Modified oligonucleotides derived from 5\u00B4-substituted nucleoside 5\u00B4-C-phosphonates: synthesis and hybridization properties"@en . "Modifikovan\u00E9 oligonukleotidy odvozen\u00E9 od 5\u00B4-substituovan\u00FDch nukleosid-5\u00B4-C-fosfon\u00E1t\u016F: synt\u00E9za a hybridiza\u010Dn\u00ED vlastnosti" . . "GP203/04/P273" . "2007-10-16+02:00"^^ . "Neuvedeno."@en . . . . . . "0"^^ . "4"^^ . . "4"^^ . . . "1"^^ . . "Synthetic approaches leading to new epimeric pure monomeric units, the 2'-deoxynucleoside-5'-C-phosphonates with nucleobases T, CBz, ABz, GDBAM, were elaborated. Novel 4\u00B4- and 5\u00B4-substituted 5\u00B4-C-phosphonate analogs of nucleotides, e.g. 4\u00B4-methoxy, 5\u00B4-me"@en . .