. . . " Lyme disease" . . "2015-12-31+01:00"^^ . "Kl\u00ED\u0161\u0165ata jsou krevsaj\u00EDc\u00ED parazit\u00E9 a vekto\u0159i z\u00E1va\u017En\u00FDch virov\u00FDch, bakteri\u00E1ln\u00EDch a protozo\u00E1ln\u00EDch onemocn\u011Bn\u00ED lid\u00ED a zv\u00ED\u0159at. Ixodes ricinus je kl\u00ED\u0161t\u011B b\u011B\u017En\u00E9 v \u010Cesk\u00E9 republice a Evrop\u011B, kde p\u0159en\u00E1\u0161\u00ED kl\u00ED\u0161\u0165ovou encefalitidu (TBE), Lymeskou boreli\u00F3zu, anaplazm\u00F3zu nebo babezi\u00F3zu. Imunizace hostitel\u016F rekombinantn\u00EDmi kl\u00ED\u0161t\u011Bc\u00EDmi proteiny postihuje s\u00E1n\u00ED kl\u00ED\u0161\u0165at a br\u00E1n\u00ED p\u0159enosu patogen\u016F z kl\u00ED\u0161t\u011Bte na hostitele. Nicm\u00E9n\u011B, dostupn\u00E9 kl\u00ED\u0161t\u011Bc\u00ED antigeny st\u00E1le nejsou dostate\u010Dn\u011B \u00FA\u010Dinn\u00E9. Zde navrhujeme pomoc\u00ED metody RNA interference (RNAi) otestovat geny kl\u00ED\u0161t\u011Bc\u00ED dr\u00E1hy metabolismu \u017Eeleza a hemu za \u00FA\u010Delem nalezen\u00ED vhodn\u00FDch vakcina\u010Dn\u00EDch kandid\u00E1t\u016F postihuj\u00EDc\u00EDch s\u00E1n\u00ED a v\u00FDvoj kl\u00ED\u0161\u0165at. Tito kandid\u00E1ti budou rovn\u011B\u017E testov\u00E1ni na sv\u016Fj potenci\u00E1l br\u00E1nit p\u0159enosu bor\u00E9li\u00ED z kl\u00ED\u0161t\u011Bte na hostitele. V\u011B\u0159\u00EDme, \u017Ee vakcinace hostitel\u016F t\u011Bmito proteiny m\u00E1 velk\u00FD potenci\u00E1l jako strategie vedouc\u00ED k redukci po\u010Dtu kl\u00ED\u0161\u0165at a p\u0159enosu patogen\u016F." . "tick" . . . "http://www.isvav.cz/projectDetail.do?rowId=GP13-27630P"^^ . . "2014-04-07+02:00"^^ . . . " vaccine" . . " Ixodes" . "2015-02-09+01:00"^^ . "4"^^ . "0"^^ . "4"^^ . "1"^^ . . "Ticks are blood-feeding parasites and vectors of some of the most devastating viral, bacterial, and protozoal diseases known to humans and animals. Ixodes ricinus is a common tick in the Czech Republic and Europe, transmitting tick-borne encephalitis (TBE), Lyme disease (borreliosis), anaplasmosis, or babesiosis. Immunization of the hosts using recombinant tick proteins reduces tick feeding and, more importantly, blocks transmission of pathogens from the tick into the host. However, available tick antigens still do not reach a sufficient efficacy. Here we propose RNA interference (RNAi) screen of I. ricinus genes, potentially involved in the tick iron metabolism and heme acquisition, in order to find suitable vaccine candidates affecting tick feeding and development. These candidates will be also tested for their potential to inhibit transmission of Borrelia spirochetes from the tick into the host. We believe that vaccination with these proteins has a great potential as a control strategy to reduce tick numbers and transmission of pathogens."@en . "Proteins of the tick iron metabolism pathway \u2013 antigens for a new vaccine against ticks and tick-transmitted diseases"@en . "0"^^ . . . " RNAi" . . "2013-02-01+01:00"^^ . "GP13-27630P" . . . "tick, Ixodes, RNAi, vaccine, Lyme disease, Borrelia"@en . "Proteiny dr\u00E1hy metabolismu \u017Eeleza u kl\u00ED\u0161\u0165at \u2013 antigeny pro novou vakc\u00EDnu proti kl\u00ED\u0161\u0165at\u016Fm a jimi p\u0159en\u00E1\u0161en\u00FDm patogen\u016Fm" . . . .