. . . . " intermetallic and carbon nanoparticles" . "2015-02-09+01:00"^^ . . . . "2013-02-01+01:00"^^ . . "Navrhovan\u00FD projekt je zam\u011B\u0159en na v\u00FDvoj nov\u00FDch elektrochemick\u00FDch DNA biosenzor\u016F na b\u00E1zi nanostrukturovan\u00FDch vodiv\u00FDch rozhran\u00ED pro komplexn\u00ED detekci po\u0161kozen\u00ED DNA. Pozornost bude v\u011Bnov\u00E1na vyu\u017Eit\u00ED komer\u010Dn\u011B dostupn\u00FDch (nanotrubi\u010Dky, fullereny, grafen) i nov\u011B v r\u00E1mci projektu p\u0159ipraven\u00FDch nano\u010D\u00E1stic (koloidn\u00ED nano\u010D\u00E1stice zlata, st\u0159\u00EDbra, st\u0159\u00EDbrn\u00E9ho amalg\u00E1mu a sr\u00E1\u017Eec\u00EDmi reakcemi p\u0159ipraven\u00E9 nanoslou\u010Deniny) za\u010Dlen\u011Bn\u00FDch do polymern\u00EDch film\u016F elektrochemicky generovan\u00FDch (nebo fyzisorpc\u00ED nav\u00E1zan\u00FDch) na povrchu senzoru. Takto vytvo\u0159en\u00E1 nanostrukturovan\u00E1 rozhran\u00ED (elektrochemick\u00E9 p\u0159evodn\u00EDky) budou testov\u00E1na jednak jako zesilova\u010De elektrochemick\u00E9 odezvy n\u00E1sledn\u011B nav\u00E1zan\u00E9 DNA (v\u00FDvoj biosenzorick\u00E9ho rozhran\u00ED pro komplexn\u00ED elektrochemickou detekci po\u0161kozen\u00ED DNA vybran\u00FDmi xenobiotiky ze skupin chemick\u00FDch karcinogen\u016F a modern\u00EDch onkologick\u00FDch a neurodegenerativn\u00EDch l\u00E9\u010Div) a z\u00E1rove\u0148 jako rozhran\u00ED umo\u017E\u0148uj\u00EDc\u00EDch detailn\u00ED charakterizaci interakce DNA se studovan\u00FDm xenobiotikem." . . " Nanocompounds" . "4"^^ . "0"^^ . "4"^^ . "1"^^ . . "GP13-23337P" . . "http://www.isvav.cz/projectDetail.do?rowId=GP13-23337P"^^ . . "0"^^ . . "DNA biosensors; Metallic, intermetallic and carbon nanoparticles; Nanocompounds; Chemically modified electrodes; Amplification of electrochemical response; Complex detection of DNA damage; Voltammetry; Electrochemical Impedance Spectroscopy; Chemical ca\u2026"@en . " Voltammetry" . "DNA biosensors" . . " Metallic" . "The proposed project is focused on the development of new electrochemical DNA biosensors based on nanostructured conductive interfaces for complex electrochemical detection of DNA damage. Attention will be paid to the use of commercially available (nanotubes, fullerenes, graphene) and newly prepared nanoparticles (colloidal nanoparticles of gold, silver, silver amalgam and nanocompounds prepared by precipitation reactions) integrated into a polymer film electrochemically generated (or attached by physisorption) on a sensor surface. Thus prepared nanostructured interfaces (electrochemical transducers) will be tested (i) as the amplifiers of electrochemical response of subsequently attached DNA (development of biosensoric interface for complex electrochemical detection of DNA damage by xenobiotics selected from chemical carcinogens and modern oncologic and neurodegenerative drugs) and (ii) as the interfaces enabling detailed characterization of the DNA interaction with studied xenobiotic."@en . . " Electrochemical Impedance Spectroscopy" . "Complex diagnostic approach in the evaluation of the interaction of DNA with organic xenobiotics using electrochemical nanostructured DNA biosensors"@en . "Komplexn\u00ED diagnostick\u00FD p\u0159\u00EDstup p\u0159i hodnocen\u00ED interakce DNA s organick\u00FDmi xenobiotiky pomoc\u00ED elektrochemick\u00FDch nanostrukturovan\u00FDch DNA biosenzor\u016F" . " Amplification of electrochemical response" . "2015-12-31+01:00"^^ . . " Chemically modified electrodes" . " Complex detection of DNA damage" . . "2014-04-07+02:00"^^ .