"0"^^ . "2"^^ . . . "2"^^ . "There is an increasing evidence that immature subjects exposed to noise during the sensitive period of development may suffer from various hearing disorders in adulthood. Previous experiments of the Prague group in rats demonstrated that a less precise frequency tuning and disturbances in the processing of sound intensity can be produced by a several minutes lasting loud noise exposure at postnatal day 14. Changes in sound processing in the central auditory pathway and altered neuronal morphology has been described by the Taiwan group after 1-week of exposure at 3rd or 4th postnatal weeks to moderate-intensity tones. The bilateral project is proposed to investigate the detailed mechanisms of the structural and functional changes in the auditory system after noise exposure during the different parts of the sensitive period of development. With the aim to ameliorate the effects of noise exposure, young rats will be exposed to enriched acoustical environment. For this purpose a combination of advanced methodological approaches of both groups will be used to achieve high quality synergy."@en . "Plastick\u00E9 zm\u011Bny neuronov\u00FDch s\u00EDt\u00ED po ohlu\u0161en\u00ED v ran\u00E9m obdob\u00ED v\u00FDvoje." . . . "2014-07-15+02:00"^^ . . . "2014-12-31+01:00"^^ . "V sou\u010Dasn\u00E9 dob\u011B existuje mnoho d\u016Fkaz\u016F o tom, \u017Ee jedinci exponovan\u00ED hluku v citliv\u00E9m obdob\u00ED jejich v\u00FDvoje mohou trp\u011Bt sluchov\u00FDmi poruchami\u00A0v dosp\u011Blosti. P\u0159edchoz\u00ED v\u00FDsledky v\u011Bdeck\u00E9 skupiny v Praze uk\u00E1zaly, \u017Ee dosp\u011Bl\u00ED potkani, kte\u0159\u00ED byli ohlu\u0161eni ve 14.\u00A0postnat\u00E1ln\u00EDm dnu intenzivn\u00EDm \u0161umem po dobu n\u011Bkolika minut, m\u011Bli zhor\u0161enou frekven\u010Dn\u00ED selektivitu a poruchy ve vn\u00EDm\u00E1n\u00ED intenzity zvuku.\u00A0Zm\u011Bny ve vn\u00EDm\u00E1n\u00ED intenzity zvuku a zm\u011Bn\u011Bnou morfologii neuron\u016F byly pozorov\u00E1ny i na pracovi\u0161ti na Taiwanu po expozici potkan\u016F t\u00F3nem o men\u0161\u00ED intenzit\u011B ve 3. nebo 4. postnat\u00E1ln\u00EDm t\u00FDdnu. N\u00E1vrh bilater\u00E1ln\u00EDho projektu je zam\u011B\u0159en na v\u00FDzkum detailn\u00EDch mechanizm\u016F vzniku struktur\u00E1ln\u00EDch a funk\u010Dn\u00EDch zm\u011Bn ve sluchov\u00E9m syst\u00E9mu po\u00A0expozici intenzivn\u00EDho zvuku v r\u016Fzn\u00E9m obdob\u00ED v\u00FDvoje. Mlad\u00ED potkani budou vystaveni obohacen\u00E9mu prost\u0159ed\u00ED\u00A0s c\u00EDlem sn\u00ED\u017Een\u00ED negativn\u00EDch n\u00E1sledk\u016F hlukov\u00E9 expozice. Za \u00FA\u010Delem z\u00EDsk\u00E1n\u00ED kvalitn\u00EDch v\u00FDsledk\u016F budou v obou t\u00FDmech pou\u017Eity komplexn\u00ED experiment\u00E1ln\u00ED metody. \u00A0" . . "http://www.isvav.cz/projectDetail.do?rowId=GCP303/11/J005"^^ . . "noise central auditory system"@en . "0"^^ . . . "2013-06-06+02:00"^^ . . "Neural remodeling after early sound exposures"@en . . . . . "1"^^ . "GCP303/11/J005" . "2011-01-01+01:00"^^ . . .