"chronic renal failure" . . . "The role of impaired renal autoregulation and the tissue renin-angiotensin-aldosterone system in the pathophysiology of chronic renal failure"@en . . "2010-12-31+01:00"^^ . "\u00DAloha zhor\u0161en\u00E9 ren\u00E1ln\u00ED autoregulace a tk\u00E1\u0148ov\u00E9ho renin-angiotenzinov\u00E9ho syst\u00E9mu v patofyziologii chronick\u00E9 ren\u00E1ln\u00ED insuficience" . . . . . . . . "Hypertenze spolu s\u00A0renin-angiotenzin-aldosteronov\u00FDm syst\u00E9mem (RAAS)hraj\u00ED d\u016Fle\u017Eitou \u00FAlohu v\u00A0rozvoji chronick\u00E9 ren\u00E1ln\u00ED insuficience (CHRI). Je zn\u00E1mo, \u017Ee blok\u00E1da RAAS vykazuje sv\u00E9 p\u016Fsoben\u00ED nejen p\u0159es sn\u00ED\u017Een\u00ED krevn\u00EDho tlaku, ale nav\u00EDc sv\u00FDmi renoprotektivn\u00EDmi\u00FA\u010Dinky v\u00FDrazn\u011B zpomaluje progresi CHRI. Av\u0161ak tato tvrzen\u00ED pon\u011Bkud zpochyb\u0148uje ned\u00E1vn\u00E1 studie na modelu ren\u00E1ln\u00ED 5/6 ablace ukazuj\u00EDc\u00ED, \u017Ee antihypertenz\u00EDva, kter\u00E1\u00A0 nem\u011Bn\u00ED ren\u00E1ln\u00ED autoregulaci, maj\u00ED renoprotektivn\u00ED p\u016Fsoben\u00ED ekvivalentn\u00ED l\u00E9k\u016Fm blokuj\u00EDc\u00EDm RAAS, pokud je dosa\u017Eeno stejn\u00E9ho sn\u00ED\u017Een\u00ED krevn\u00EDho tlaku (TK). Z\u00A0tohoto d\u016Fvodu se p\u0159edpokl\u00E1d\u00E1, \u017Ee blok\u00E1da RAAS neposkytuje renoprotektivn\u00ED p\u016Fsoben\u00ED na TK nez\u00E1visl\u00E9. Na\u0161\u00EDm c\u00EDlem je tedy objasnit a identifikovat pod\u00EDl t\u011Bchto dvou slo\u017Eek-tedy na tlaku z\u00E1visl\u00E9 a nez\u00E1visl\u00E9- v\u00A0patofyziologii CHRI. Pro studium progrese/regrese glomeruloskler\u00F3zy u modelu 5/6 nefrektomie jsme se rozhodli pou\u017E\u00EDt model renin transgenn\u00EDch potkan\u016F s\u00A0vlo\u017Een\u00FDm my\u0161\u00EDm reninov\u00FDm genem p\u0159edstavuj\u00EDc\u00ED monogenetick\u00FD model hypertenze se" . . " 5/6 ablation model" . . . . "2010-04-16+02:00"^^ . "http://www.isvav.cz/projectDetail.do?rowId=GC305/08/J006"^^ . "13"^^ . "13"^^ . . " glomerulosclerosis" . . "2015-02-09+01:00"^^ . "The first aim of the present study was to characterize the role of the impaired autoregulatory efficiency of renal hemodynamics in the pathophysiology of angiotensin II (ANG II)-dependent form of hypertension and the progression of chronic renal failure. In addition, the second aim of the present study was to evaluate the role of claimed blood pressure (BP)-independent cardio- and renoprotective"@en . . "0"^^ . "chronic renal failure; 5/6 ablation model; glomerulosclerosis; renin-angiotensin-aldosterone system"@en . "GC305/08/J006" . "1"^^ . . . "Hypertension and the renin-angiotensin-aldosterone system (RAAS) play a major role in the progression of chronic kidney disease (CKD). It has been claimed that blockade of RAAS provides renoprotective effects in attenuating the progression of CKD that goes well beyond their effects on blood pressure (BP). However, the claim for BP-independent renoprotective effects achieved by blockade of the RAAS has been questioned by recent studies performed in the 5/6 renal ablation model showing that antihypertensive drugs that do not alter renal autoregulation can provide renoprotective effects that are equivalent to those afforded by drugs that block the RAAS if the same BP reduction is achieved. Therefore, it has been suggested that the blockade of the RAAS does not provide BP-independent renoprotective effects. The aim of our project is to clarify the relative role of BP-dependent versus BP-independent effects of the blockade of the RAAS in the pathophysiology of CKD. In order to address this"@en . "0"^^ . "Prvn\u00EDm c\u00EDlem t\u00E9to grantov\u00E9 studie bylo objasnit \u00FAlohu zhor\u0161en\u00E9 autoregulace ren\u00E1ln\u00ED hemodynamiky v patofyziologii angiotenzin II (ANG II)-dependentn\u00ED formy hypertenze a progrese chronick\u00E9 ren\u00E1ln\u00ED insuficience (CHRI). Druh\u00FDm c\u00EDle bylo zjistit, zda existuj\u00ED tzv. \u201Ena krevn\u00EDm tlaku (TK)-nez\u00E1visl\u00E9\u201C nefroprotektivn\u00ED a kardioprotektivn\u00ED \u00FA\u010Dinky antihypertenzn\u00ED terapie, kter\u00E1 blokuje aktivitu renin-a"@cs . "2008-01-01+01:00"^^ .