. . . "3"^^ . "1"^^ . "124"^^ . "GBP304/12/G069" . . "124"^^ . "Project of excellence in the field of neuroscience"@en . . . "Neurodegenerativn\u00ED onemocn\u011Bn\u00ED se \u010Dasto vyskytuj\u00ED u st\u00E1rnouc\u00ED populace, ale i u mlad\u00FDch jedinc\u016F a p\u0159edstavuj\u00ED z\u00E1va\u017En\u00FD socio-ekonomick\u00FD probl\u00E9m. Tato etiologicky r\u016Fznorod\u00E1 onemocn\u011Bn\u00ED vedou k v\u00E1\u017En\u00FDm kognitivn\u00EDm, motorick\u00FDm a senzorick\u00FDm poruch\u00E1m. C\u00EDlem projektu je objasnit patofyziologick\u00E9 mechanismy vzniku t\u011Bchto chorob od \u00FArovn\u011B genetick\u00E9 a\u017E po syst\u00E9movou. Dosa\u017Een\u00ED c\u00EDle bude umo\u017En\u011Bno d\u00EDky inter-disciplin\u00E1rn\u00ED spolupr\u00E1ci n\u011Bkolika v\u00FDznamn\u00FDch v\u011Bdeck\u00FDch t\u00FDm\u016F v \u010Cesk\u00E9 republice; tak n\u00E1ro\u010Dn\u00FD \u00FAkol nen\u00ED mo\u017En\u00E9 \u0159e\u0161it v r\u00E1mci individu\u00E1ln\u00EDch projekt\u016F jednotliv\u00FDch t\u00FDm\u016F. S vyu\u017Eit\u00EDm \u0161irok\u00E9ho metodick\u00E9ho z\u00E1zem\u00ED budou studov\u00E1ny mechanismy regulace genov\u00E9 exprese, funkce membr\u00E1nov\u00FDch receptor\u016F (s d\u016Frazem na NMDA receptory), mezibun\u011B\u010Dn\u00E9 komunikace, modulace extracelul\u00E1rn\u00EDho prostoru a funkce gliov\u00FDch bun\u011Bk. Objasn\u011Bn\u00ED z\u00E1kladn\u00EDch mechanism\u016F neurodegenerativn\u00EDch onemocn\u011Bn\u00ED povede k jejich inovativn\u00ED a efektivn\u00ED l\u00E9\u010Db\u011B, nap\u0159. s vyu\u017Eit\u00EDm neurosteroid\u016F \u010Di kmenov\u00FDch bun\u011Bk. Projekt poskytne optim\u00E1ln\u00ED z\u00E1zem\u00ED pro vysoce kvalitn\u00ED postgradu\u00E1ln\u00ED v\u00FDuku neurov\u011Bd." . . . "neurodegeneration Alzheimer's disease neurotransmitter receptors neurons glia"@en . "2018-12-31+01:00"^^ . . . . "2012-01-01+01:00"^^ . . "2015-02-09+01:00"^^ . . "2014-04-07+02:00"^^ . . . "http://www.isvav.cz/projectDetail.do?rowId=GBP304/12/G069"^^ . "0"^^ . . "Neurodegenerative disorders are common in the aging population, but also in young adults, and have become a serious socio-economic problem. These etiologically heterogenous diseases lead to severe cognitive, motor and sensory deficiencies. The proposal aims to elucidate the pathophysiological mechanisms underlying the development of these diseases, from the genetic up to the system level. The project will enable creation of a network of high level scientific teams and thus promote an inter-disciplinary approach that would otherwise not be feasible based on individual projects of any single partner. Using a broad battery of methods, the mechanisms involved in regulating gene expression, membrane receptor function, inter-cellular communication, extra-cellular space modulation, and glia function will be investigated. As the research will be aimed at understanding basic processes, the output will lead to innovative and effective treatments of the diseases, e.g. using neuroactive steroids, stem cells etc. The project will also provide a unique basis for PhD training in neuroscience."@en . . "Projekt excelence v oblasti neurov\u011Bd" .