"97"^^ . "The Project of Excellence represents a continuation of the successful Centre of Basic Research LC535 and will bring together the best Czech teams interested in the arrangement and function of the cell nucleus and epigenetics in normal and cancer cells either intact or damaged. We will accent the research of epigenetics and DNA damage in human pluripotent stem cells in relation to oncogenic transformation. Research in this field can provide highly important practical implications. Practical significance can be also expected from the research of complex chromosomal aberrations. Participation of computer scientists in the project will enable development of control software for microscope systems as well as high-level analysis of the results. Multidiciplinary nature of the consortium will enable the use of complementarity in methods and approaches, achieve synergistic effects, join elements of basic and applied research and solve difficult objectives. The joint research will generate a high added value leading to the growth of scientific excellence and of an international recognition."@en . . "97"^^ . "0"^^ . . . . "2014-04-07+02:00"^^ . . . "Dynamics and Organization of Chromosomes in the Cell Cycle and during Differentiation under Normal and Pathological Conditions"@en . . . . "2012-01-01+01:00"^^ . . . "Projekt excelence navazuje na podobn\u011B pojmenovan\u00FD \u00FAsp\u011B\u0161n\u00FD projekt Centra z\u00E1kladn\u00EDho v\u00FDzkumu LC535 a propoj\u00ED nejlep\u0161\u00ED \u010Desk\u00E9 t\u00FDmy zab\u00FDvaj\u00EDc\u00ED se uspo\u0159\u00E1d\u00E1n\u00EDm a funkc\u00ED j\u00E1dra bu\u0148ky a epigenetikou bun\u011Bk zdrav\u00FDch i n\u00E1dorov\u00FDch, v norm\u011B i p\u0159i po\u0161kozen\u00ED. D\u016Fraz bude kladen na v\u00FDzkum epigenetiky a po\u0161kozen\u00ED DNA u lidsk\u00FDch pluripotentn\u00EDch kmenov\u00FDch bun\u011Bk v souvislosti s n\u00E1dorovou transformac\u00ED. Dal\u0161\u00ED v\u00FDzkum v t\u00E9to oblasti m\u016F\u017Ee m\u00EDt obrovsk\u00FD dopad do praxe. Praktick\u00FD v\u00FDznam lze tak\u00E9 o\u010Dek\u00E1vat od v\u00FDzkumu komplexn\u00EDch chromosom\u00E1ln\u00EDch aberac\u00ED. \u00DA\u010Dast informatik\u016F v projektu umo\u017En\u00ED v\u00FDvoj \u0159\u00EDd\u00EDc\u00EDho softwaru pro mikroskopickou techniku a velmi fundovanou anal\u00FDzu z\u00EDskan\u00FDch v\u00FDsledk\u016F. Multidisciplin\u00E1rn\u00ED povaha konsorcia projektu umo\u017En\u00ED vyu\u017E\u00EDt komplement\u00E1rn\u00ED metodiky a experiment\u00E1ln\u00ED p\u0159\u00EDstupy, dos\u00E1hnout synergick\u00FDch efekt\u016F, propojit prvky z\u00E1kladn\u00EDho a aplikovan\u00E9ho v\u00FDzkumu, \u0159e\u0161it nejn\u00E1ro\u010Dn\u011Bj\u0161\u00ED \u00FAkoly. Spole\u010Dn\u00FD v\u00FDzkum tak bude m\u00EDt vysokou p\u0159idanou hodnotu, kter\u00E1 se projev\u00ED v\u00FDrazn\u00FDm r\u016Fstem excelence a mezin\u00E1rodn\u00ED \u00FArovn\u011B z\u00FA\u010Dastn\u011Bn\u00FDch pracovi\u0161\u0165." . "Dynamika a organizace chromosom\u016F b\u011Bhem bun\u011B\u010Dn\u00E9ho cyklu a p\u0159i diferenciaci v norm\u011B a patologii" . . "http://www.isvav.cz/projectDetail.do?rowId=GBP302/12/G157"^^ . "chromosomes chromatin cell cycle differentiation ES cells DNA repair chromosomal aberrations"@en . . "3"^^ . "1"^^ . . . . . . . "GBP302/12/G157" . "2018-12-31+01:00"^^ . "2015-02-09+01:00"^^ .