"http://www.isvav.cz/projectDetail.do?rowId=GAP502/11/2116"^^ . "0"^^ . . . . "15"^^ . "15"^^ . . "Kl\u00ED\u0161\u0165ov\u00E1 encefalitida (KE) p\u0159edstavuje z\u00E1va\u017En\u00E9 virov\u00E9 onemocn\u011Bn\u00ED centr\u00E1ln\u00ED nervov\u00E9 soustavy \u010Dlov\u011Bka. Navzdory v\u00FDznamu t\u00E9to infekce z\u016Fst\u00E1vaj\u00ED n\u011Bkter\u00E9 kl\u00ED\u010Dov\u00E9 ot\u00E1zky ohledn\u011B vzniku a rozvoje encefalitidy nevyjasn\u011Bny. U lid\u00ED vykazuje infekce virem KE r\u016Fznou z\u00E1va\u017Enost \u2013 od asymptomatick\u00E9 infekce, p\u0159es hore\u010Dnat\u00E9 onemocn\u011Bn\u00ED a\u017E po akutn\u00ED nebo chronickou encefalitidu. Z\u00E1va\u017Enost klinick\u00E9ho pr\u016Fb\u011Bhu KE je ovlivn\u011Bna \u0159adou faktor\u016F, mezi kter\u00E9 \u0159ad\u00EDme infek\u010Dn\u00ED d\u00E1vku a virulenci viru, v\u011Bk pacienta a stav jeho imunity, ale tak\u00E9, jak na\u0161e p\u0159edb\u011B\u017En\u00E9 v\u00FDsledky p\u0159esv\u011Bd\u010Div\u011B dokazuj\u00ED, jeho genetickou v\u00FDbavu. P\u0159edkl\u00E1dan\u00FD projekt si klade za c\u00EDl studovat rozd\u00EDly v klinick\u00E9m pr\u016Fb\u011Bhu KE a jejich genetickou determinaci. Experimenty budou provedeny s vyu\u017Eit\u00EDm unik\u00E1tn\u00EDch rekombinantn\u00EDch kongenn\u00EDch kmen\u016F my\u0161\u00ED, nebo\u0165 tyto my\u0161i vykazuj\u00ED r\u016Fzn\u00FD pr\u016Fb\u011Bh infekce, obdobn\u011B jako je tomu u \u010Dlov\u011Bka. V\u00FDsledky projektu by m\u011Bly p\u0159isp\u011Bt k pozn\u00E1n\u00ED genetick\u00E9 determinace klinick\u00E9ho pr\u016Fb\u011Bhu t\u00E9to v\u00FDznamn\u00E9 infekce." . "tick-borne encephalitis virus tick-borne encephalitis clinical course genetic determinants"@en . "Differences in clinical course of tick-borne encephalitis in host, and their genetic determination"@en . . . "2015-04-23+02:00"^^ . "2015-12-31+01:00"^^ . . "2011-01-01+01:00"^^ . . . "Tick-borne encephalitis (TBE), a disease caused by tick-borne encephalitis virus (TBEV), represents a serious viral neuroinfection of humans. Despite the medical importance of this disease, some crucial steps in the development of encephalitis remain poorly understood. In humans, TBEV may produce a variety of clinical symptoms, from an asymptomatic disease to a fever and acute or chronic progressive encephalitis. This is influenced by a variety of factors, e.g. inoculation dose and virulence of the virus, age and immune status of the host, but also, as our preliminary results strongly suggest, by susceptibility based on host genetic background. Here, we propose a research project to study differences in clinical course of tick-borne encephalitis, and its genetical determination. As a model for TBE, recombinant congenic mouse strains will be used, since these mice develop TBE of various severity, and this correlates with the situation in humans. Results of this project should improve our understanding of the genetic basis of seriousness of this important infection."@en . "GAP502/11/2116" . . . "Rozd\u00EDly v klinick\u00E9m pr\u016Fb\u011Bhu kl\u00ED\u0161\u0165ov\u00E9 encefalitidy u hostitele a jejich genetick\u00E1 determinace." . . . "1"^^ . . "1"^^ . . . . . "2014-04-18+02:00"^^ .