. . . "0"^^ . . . . . . "2014-03-31+02:00"^^ . . "2015-12-31+01:00"^^ . . . . "\u00DAloha exprese miRNA u n\u00E1dor\u016F hlavy a krku asociovan\u00FDch a neasociovan\u00FDch s HPV" . "2015-04-23+02:00"^^ . . . . . "http://www.isvav.cz/projectDetail.do?rowId=GAP304/12/2244"^^ . . "MikroRNA (miRNA) se pod\u00EDl\u00ED na regulaci genov\u00E9 exprese. Geny pro miRNA se \u010Dasto nach\u00E1z\u00ED v oblastech genomu asociovan\u00FDch se vznikem malignit \u010Di v m\u00EDstech \u010Dast\u00FDch zlom\u016F, co\u017E nazna\u010Duje, \u017Ee hraj\u00ED d\u016Fle\u017Eitou roli p\u0159i vzniku n\u00E1dorov\u00FDch onemocn\u011Bn\u00ED. Studie uk\u00E1zaly, \u017Ee \u00FArove\u0148 exprese n\u011Bkter\u00FDch miRNA se li\u0161\u00ED v n\u00E1dorov\u00E9 a zdrav\u00E9 tk\u00E1ni. Mimo to v\u00FDsledky nazna\u010Duj\u00ED, \u017Ee expresn\u00ED profil miRNA je specifick\u00FD pro r\u016Fzn\u00E9 n\u00E1dory. Studie zam\u011B\u0159en\u00E9 na miRNA u n\u00E1dor\u016F hlavy krku (HNC) potvrdily rozd\u00EDlnou \u00FArove\u0148 exprese miRNA v n\u00E1dorov\u00E9 a nen\u00E1dorov\u00E9 tk\u00E1ni, jejich v\u00FDsledky v\u0161ak nejsou jednozna\u010Dn\u00E9. Jedn\u00EDm z hlavn\u00EDch d\u016Fvod\u016F je heterogenita studovan\u00FDch soubor\u016F z hlediska anatomick\u00E9 lokalizace n\u00E1dor\u016F a etiologie jejich vzniku. Studium exprese miRNA v p\u00E1rovan\u00E9m souboru na HPV z\u00E1visl\u00FDch a nez\u00E1visl\u00FDch HNC umo\u017En\u00ED studovat rozd\u00EDly v expresi miRNA u n\u00E1dor\u016F r\u016Fzn\u00E9 etiologie. Srovn\u00E1n\u00ED miRNA expresn\u00EDch profil\u016F z n\u00E1dorov\u00E9 tk\u00E1n\u011B a z modelu izogen\u00EDch klon\u016F prim\u00E1rn\u00EDch lidsk\u00FDch keratinocyt\u016F s neintegrovanou a integrovanou formou HPV m\u016F\u017Ee d\u00E1le p\u0159in\u00E9st v\u00FDsledky objas\u0148uj\u00EDc\u00ED pochody vedouc\u00ED ke vzniku n\u00E1dor\u016F r\u016Fzn\u00E9 etiologie." . . "GAP304/12/2244" . "0"^^ . "2"^^ . "The role of microRNA expression in HPV-associated and HPV-independent head and neck tumors"@en . "2"^^ . . "MicroRNAs (miRNAs) participate in the regulation of gene expression. miRNA genes are frequently located in cancer-associated genomic regions, suggesting their role in the development of malignant tumors. Levels of expression of some miRNAs are different in tumors and in normal tissues and miRNA expression profiles are specific for different tumors. Studies on head and neck tumors (HNC) confirmed the difference in the level of expression of some miRNAs in the tumor and normal tissue but the results have not been conclusive. Sources of the variability of the data have been the heterogeneity of the studied cohorts in terms of the anatomic localization and etiology of tumors. The study of miRNA expression in a matched set of HPV-dependent and independent HNCs will allow us to characterize the differences in miRNA expression in tumors of different etiology. The comparison of miRNA expression profiles in tumor tissues and in isogenic primary human keratinocyte clones immortalized by HPV will provide information about pathways involved in the development of tumors of different etiology."@en . "2012-01-01+01:00"^^ . "1"^^ . "head and neck tumors microRNA HPV"@en .