. "3"^^ . . "2014-04-15+02:00"^^ . "3"^^ . "2014-09-08+02:00"^^ . "0"^^ . . . . "Nov\u00FD lidsk\u00FD polyomavirus, ozna\u010Den\u00FD jako MCPyV, byl ned\u00E1vno objeven v karcinomu z Merkelov\u00FDch bun\u011Bk.\u00A0 Vysok\u00E1 \u010Detnost v\u00FDskytu a zp\u016Fsob integrace virov\u00E9 DNA v\u00A0karcinomu z Merkelov\u00FDch bun\u011Bk ukazuje \u017Ee MCPyV m\u016F\u017Ee hr\u00E1t z\u00E1sadn\u00ED roli p\u0159i jeho vzniku. P\u0159edkl\u00E1dan\u00FD projekt je zac\u00EDlen na z\u00EDsk\u00E1n\u00ED znalost\u00ED o biologick\u00FDch vlastnostech MCPyV a jeho prevalenci v\u00A0\u010Cesk\u00E9 republice. Studie zahrnuje konstrukce vektor\u016F\u00A0 pro produkci jednotliv\u00FDch virov\u00FDch protein\u016F v\u00A0hmyz\u00EDch a sav\u010D\u00EDch bu\u0148k\u00E1ch a p\u0159\u00EDpravu specifick\u00FDch protil\u00E1tek. Budou studov\u00E1ny vlastnosti virov\u00FDch protein\u016F, interakce s\u00A0bun\u011B\u010Dn\u00FDmi strukturami a funkce. Z\u00A0hmyz\u00EDch bun\u011Bk produkuj\u00EDc\u00EDch proteiny kapsidy budou p\u0159ipraveny pseudokapsidy (VLPs) a pou\u017Eity jako antigen k testov\u00E1n\u00ED protil\u00E1tek proti polyomaviru MCPyV u imunokompetentn\u00EDch a imunosuprimovan\u00FDch jedinc\u016F z \u010Cesk\u00E9 republiky. V DNA izolovan\u00E9 ze vzork\u016F karcinomu z Merkelov\u00FDch bun\u011Bk bude zji\u0161\u0165ov\u00E1na p\u0159\u00EDtomnost DNA viru MCPyV.\u00A0\u00A0\u00A0\u00A0" . "Merkel cell virus prevalence LT antigen VP1 VP2 VP3 proteins VLPs"@en . . . "GAP304/10/1511" . . . . "2010-01-01+01:00"^^ . "Studium nov\u00E9ho lidsk\u00E9ho polyomaviru objeven\u00E9ho v carcinomech Merkelov\u00FDch bun\u011Bk" . . "A new human polyomavirus, Merkel cell polyomavirus (MCPyV), has been recently discovered in cells of the Merkel cell carcinomas (MCC). High frequency of detection and integration pattern of viral DNA in MCC indicates that MCPyV may play causative role in MCC development. The project is aimed to acquire knowledge of biological properties of MCPyV and its prevalence in Czech Republic. The studies will include construction of expression vectors for production of individual viral proteins in insect and mammalian cells and preparation of virus-specific antibodies. Properties, interactions in cells and functions of individual MCPyV proteins will be studied. Virus-like particles (VLPs) will be isolated from insect cells infected by recombinant baculoviruses and used as an antigen for study of MCPyV seroprevalence in immunocompetent and immunocompromised individuals from Czech Republic. DNA isolated from Czech MCC samples will be used for detection of the presence of MCPyV DNA."@en . "Study of the novel human polyomavirus (MCPyV) discovered in Merkel cell carcinomas."@en . . . . . "http://www.isvav.cz/projectDetail.do?rowId=GAP304/10/1511"^^ . . . . "1"^^ . . "1"^^ .