. . . "Projekt p\u0159inesl zaj\u00EDmav\u00E9 a klinicky uplatniteln\u00E9 v\u00FDsledky proteomick\u00E9 anal\u00FDzy metastazace. Byl \u0159e\u0161en v souladu s pl\u00E1nem a ekonomick\u00FDmi pravidly GA\u010CR. Bylo dosa\u017Eeno pozoruhodn\u00FDch v\u00FDsledk\u016F, kter\u00E9 byly publikov\u00E1ny v 5 impaktovan\u00FDch \u010Dasopisech a dal\u0161\u00EDch neimpaktovan\u00FDch periodic\u00EDch."@cs . "Studium molekul\u00E1rn\u00EDch mechanism\u016F \u010Dasn\u00E9ho metastazov\u00E1n\u00ED do lymfatick\u00FDch uzlin u karcinomu prsu n\u00EDzk\u00E9ho stupn\u011B malignity pomoc\u00ED proteomick\u00FDch technik" . "\u0160\u00ED\u0159en\u00ED karcinomu prsu formou metast\u00E1z je hlavn\u00ED p\u0159\u00ED\u010Dinou \u00FAmrtnosti pacient\u016F s touto diagn\u00F3zou. Tento projekt je zam\u011B\u0159en na detekci, verifikaci a validaci exprese protein\u016F souvisej\u00EDc\u00EDch s metastazov\u00E1n\u00EDm u mal\u00FDch karcinom\u016F prsu s n\u00EDzk\u00FDm stupn\u011Bm malignity, kter\u00E9 v rozporu s teoretickou progn\u00F3zou vykazuj\u00ED \u010Dasn\u00E9 uzlinov\u00E9 metast\u00E1ze. Klinicky velmi dob\u0159e definovan\u00FD soubor prim\u00E1rn\u00EDch n\u00E1dor\u016F je k tomuto \u00FA\u010Delu ji\u017E vybr\u00E1n. C\u00EDlov\u00E9 proteiny budou detegov\u00E1ny kombinac\u00ED komplement\u00E1rn\u00EDch vysokorozli\u0161ovac\u00EDch proteomick\u00FDch p\u0159\u00EDstup\u016F s r\u016Fzn\u00FDmi analytick\u00FDmi principy a validov\u00E1ny na r\u016Fzn\u00FDch biologick\u00FDch \u00FArovn\u00EDch. \u00DAloha molekul\u00E1rn\u00EDch c\u00EDl\u016F, kter\u00E9 ji\u017E byly detegov\u00E1ny v na\u0161ich p\u0159edb\u011B\u017En\u00FDch experimentech, bude rovn\u011B\u017E detailn\u011B studov\u00E1na. O\u010Dek\u00E1v\u00E1me, \u017Ee na\u0161e v\u00FDsledky pomohou popsat molekul\u00E1rn\u00ED mechanismy metastazov\u00E1n\u00ED u t\u00E9to klinicky z\u00E1va\u017En\u00E9 skupiny n\u00E1dor\u016F a povedou k n\u00E1vrhu\u00A0potenci\u00E1ln\u00EDch marker\u016F jejich metastatick\u00E9ho potenci\u00E1lu." . . . . "breast" . "http://www.isvav.cz/projectDetail.do?rowId=GAP304/10/0868"^^ . "breast; cancer; proteomics"@en . "2012-12-31+01:00"^^ . "The interesting and clinically important results about the metastasation were obtained employing proteomic analysis. The project has been realised according economicval rules of grant agency. The data were published in 5 impacted and other non-impacted journals."@en . . . "2014-01-30+01:00"^^ . " cancer" . "The proteomics-based study on molecular mechanisms of early lymph node metastases formation in low-grade breast cancer"@en . . . . . . "2010-01-01+01:00"^^ . "20"^^ . "Metastasis, the spread of breast cancer to other locations in the body, is the main reason that leads to the mortality of patients with this diagnosis. This project is focused on discovery, verification and validation of proteins related to metastatic processes in breast cancer in small, low grade breast cancer tumors which, in disagreement with theoretical prognosis, start with metastases formation early and exhibit lymph node metastases. Clinically well defined set of primary breast tumor tissues has been selected for this purpose. Target proteins will be identified by a combination of complementary high resolution proteomic methods with various analysis principles and validated at different biological levels. Furthermore, molecular roles of targets identified in our preliminary experiments will be studied by the use of different proteomic and genomic approaches in detail. We expect that our results will help to describe the molecular mechanisms of metastasis in this group of clinically significant tumors and can identify potential markers of their metastatic potential."@en . "20"^^ . . . . "1"^^ . "2012-03-30+02:00"^^ . . "2"^^ . "GAP304/10/0868" . . . "0"^^ .