. . "2015-05-22+02:00"^^ . . "Virus kl\u00ED\u0161\u0165ov\u00E9 encefalitidy je v\u00FDznamn\u00FDm lidsk\u00FDm patogenem zp\u016Fsobuj\u00EDc\u00EDm z\u00E1va\u017En\u00E9 onemocn\u011Bn\u00ED centr\u00E1ln\u00ED nervov\u00E9 soustavy. I p\u0159es dosavadn\u00ED intenzivn\u00ED v\u00FDzkum mechanizm\u016F patogeneze tohoto onemocn\u011Bn\u00ED z\u016Fst\u00E1v\u00E1 mnoho ot\u00E1zek nezodpov\u011Bzen\u00FDch. N\u00E1\u0161 projekt je zam\u011B\u0159en na v\u00FDzkum vybran\u00FDch aspekt\u016F ovliv\u0148uj\u00EDc\u00EDch \u017Eivotn\u00ED cyklus viru a jeho interakci s hostitelem na molekul\u00E1rn\u00ED, bun\u011B\u010Dn\u00E9 a organism\u00E1ln\u00ED \u00FArovni. Hlavn\u00EDmi c\u00EDli projektu bude p\u0159in\u00E9st nov\u00E9 poznatky v oblasti v\u00FDznamn\u00FDch protivirov\u00FDch protein\u016F, regulace synt\u00E9zy virov\u00FDch protein\u016F hostitelskou bu\u0148kou, synt\u00E9zy \u010Depi\u010Dky virov\u00E9ho genomu a role glykosylace virov\u00FDch protein\u016F v invazi viru do hostitelsk\u00FDch bun\u011Bk, jeho replikaci a virulenci. Pr\u00E1ce bude prob\u00EDhat jak v podm\u00EDnk\u00E1ch in vitro, tak in vivo s vyu\u017Eit\u00EDm \u0161irok\u00E9 palety experiment\u00E1ln\u00EDch metod. V\u00FDsledky tohoto projektu poslou\u017E\u00ED k lep\u0161\u00EDmu porozum\u011Bn\u00ED infekci hostitelsk\u00E9ho organizmu virem kl\u00ED\u0161\u0165ov\u00E9 encefalitidy, prohloub\u00ED na\u0161e znalosti o flavivirech v\u0161eobecn\u011B a p\u0159inesou nov\u00E9 poznatky pro dal\u0161\u00ED v\u00FDzkum z\u00E1va\u017En\u00FDch flavivirov\u00FDch onemocn\u011Bn\u00ED." . . "1. V\u00FDsledky projektu jsou p\u0159\u00EDnosem k zmapov\u00E1n\u00ED patogeneze viru a praktick\u00FD dopad m\u016F\u017Ee m\u00EDt objev nov\u00E9ho potenci\u00E1ln\u00EDho inhibitoru. 2. \u00DAdaje \u0159e\u0161itele jsou adekv\u00E1tn\u00ED. 3. Projekt m\u00E1 v\u00FDznam pro terapii KE. 4. Uznan\u00FDm v\u00FDstupem projektu jsou 3 publikace s IF av\u0161ak s mnoho\u010Detnou dedikac\u00ED. 5. Grant byl zpracov\u00E1n podle pravidel. Finan\u010Dn\u00ED prost\u0159edky byly vynalo\u017Eeny odpov\u00EDdaj\u00EDc\u00EDm zp\u016Fsobem."@cs . "Tick-borne encephalitis virus-host interaction on the molecular, cellular and organismal level"@en . . "http://www.isvav.cz/projectDetail.do?rowId=GAP302/12/2490"^^ . "Tick-borne encephalitis virus represents an important human pathogen, causing severe infection of the central nervous system. Although an enormous effort was made to understand pathogenesis of this disease, a lot of questions remain unresolved. The proposed project is oriented on the research of selected aspects affecting life cycle of the virus and its interaction with the host on the molecular, cellular and organismal level. Main goals of the project are to bring new findings in the area of antiviral proteins, capping of TBEV genome, regulation of viral protein synthesis by the host cell, and viral protein glycosylation in TBEV invaded host cells, viral replication and virulence. The experiments will be carried out in vitro as well as in vivo using a broad array of experimental techniques. Our results will provide a closer insight in the basic aspects of pathogenesis of TBE and it will deepen our understanding of flaviviruses generally and will benefit the successive advanced research of severe flaviviral infections."@en . . "0"^^ . "2012-01-01+01:00"^^ . "4"^^ . "tick-borne encephalitis virus translation proteosynthesis antiviral proteins glycosylation"@en . . "4"^^ . "1"^^ . . "Interakce viru kl\u00ED\u0161\u0165ov\u00E9 encefalitidy s hostitelem na molekul\u00E1rn\u00ED, bun\u011B\u010Dn\u00E9 a organism\u00E1ln\u00ED \u00FArovni" . . . "GAP302/12/2490" . . . . . . "0"^^ . . "1. Project outcomes bring added value to mapping of virus pathogenesis and discovery of a new potential inhibitor may have practical impact. 2. Data of investigator are valid. 3. Project is important for therapy of TBE. 4. Recognized project outcomes are 3 papers with IF, all with multiple dedication. 5. Grant was processed according to the rules. Financial sources were spent appropriately."@en . . "2014-03-31+02:00"^^ . . . "2014-12-31+01:00"^^ .