. . "Chromatin structure DNA repair epigenetics"@en . . "0"^^ . "24"^^ . "Chromatin dynamics during DNA repair"@en . "2010-01-01+01:00"^^ . . "24"^^ . . . . "Dynamika chromatinu v pr\u016Fb\u011Bhu reparace DNA" . "2014-12-31+01:00"^^ . . . "1"^^ . . "Cells have developed sophisticated\u00A0mechanisms to overcome damage to\u00A0DNA resulting in double-strand breaks (DSBs) induced by toxic agents\u00A0of our environment. Improper repair of DSBs can lead to the development of cancer. Once\u00A0a cancer has developed, radiation and chemotherapy are used to damage DNA\u00A0in order\u00A0to kill the tumor cells. Thus, the information of how cells respond to DNA damage is critical for understanding both the development of cancer and its therapy. We want to contribute to this knowledge by the elucidation of the processes changing\u00A0the chromatin structure in the DSB vicinity. Chromatin changes\u00A0represent the fundamental response of the cell\u00A0to DSB induction that should allow the access of repair\u00A0proteins to DNA for efficient signaling and repair. It should be found how the chromatin structure is modified, what is the difference in\u00A0chromatin dynamics in open and compact chromatin compartments\u00A0and how are all these processes coordinated in time to allow accumulation of repair proteins for full restoration of genome integrity.\u00A0"@en . "http://www.isvav.cz/projectDetail.do?rowId=GAP302/10/1022"^^ . . . . . "0"^^ . "Projekt p\u0159isp\u011Bl k objasn\u011Bn\u00ED vztahu mezi strukturou a funkc\u00ED chromatinu v bun\u011B\u010Dn\u00FDch procesech, nap\u0159. p\u0159i reparaci dvou\u0159et\u011Bzcov\u00FDch zlom\u016F a bun\u011B\u010Dn\u00E9 diferenciaci. V\u00FDsledky byly publikov\u00E1ny v 25 \u010Dl\u00E1nc\u00EDch v impaktovan\u00FDch a v\u011Bt\u0161inou velmi kvalitn\u00EDch \u010Dasopisech, co\u017E je v\u00FDrazn\u011B nad pr\u016Fm\u011Brem. Celkov\u00E9 hodnocen\u00ED projektu je tud\u00ED\u017E klasifikov\u00E1no jako vynikaj\u00EDc\u00ED. Finance byly \u010Derp\u00E1ny v souladu s pravidly."@cs . "2015-05-22+02:00"^^ . . "The project contributed to clarification of the relationship between structure and function of chromatin in cell processes, e.g. during the repair of double strand breaks and cell differentiation. Results were published in 25 papers in journals with IF, mainly of high quality. Such outcome is clearly exceptional, therefore the final report is ranked as %22excellent%22."@en . "GAP302/10/1022" . . . . . "Bu\u0148ky vyvinuly sofistikovan\u00FD postup jak se vypo\u0159\u00E1dat s\u00A0po\u0161kozen\u00EDm integrity DNA a se vznikem dvoj\u0159et\u011Bzcov\u00FDch zlom\u016F (DSBs) indukovan\u00FDch toxick\u00FDmi \u010Dinidly\u00A0 na\u0161eho \u017Eivotn\u00EDho prost\u0159ed\u00ED. Nespr\u00E1vn\u00E9 opraven\u00ED DSBs m\u016F\u017Ee v\u00E9st ke vzniku n\u00E1dor\u016F. Jakmile se n\u00E1dor objev\u00ED, pou\u017E\u00EDv\u00E1 se ionizuj\u00EDc\u00ED z\u00E1\u0159en\u00ED a chemoterapie k\u00A0tomu, aby se zahubily n\u00E1dorov\u00E9 bu\u0148ky. Tak\u017Ee pozn\u00E1n\u00ED toho jak bu\u0148ky odpov\u00EDdaj\u00ED na po\u0161kozen\u00ED DNA, je d\u016Fle\u017Eit\u00E9 pro pochopen\u00ED jak v\u00FDvoje tak terapie n\u00E1dorov\u00E9ho onemocn\u011Bn\u00ED. My chceme p\u0159isp\u011Bt k\u00A0tomuto pozn\u00E1n\u00ED objasn\u011Bn\u00EDm proces\u016F, participuj\u00EDc\u00EDch na\u00A0zm\u011Bn\u00E1ch struktury chromatinu v\u00A0okol\u00ED DSBs. Zm\u011Bna struktury chromatinu je rozhoduj\u00EDc\u00ED odpov\u011Bd\u00ED bu\u0148ky na indukci DSBs, proto\u017Ee m\u00E1 umo\u017Enit p\u0159\u00EDstup sign\u00E1ln\u00EDch a repara\u010Dn\u00EDch protein\u016F do m\u00EDsta po\u0161kozen\u00ED. Je t\u0159eba objasnit jak je struktura chromatinu v\u00A0m\u00EDst\u011B DSB modifikov\u00E1na,\u00A0jak\u00FD je rozd\u00EDl\u00A0dynamiky chromatinu v otev\u0159en\u00FDch a kompaktn\u00EDch oblastech j\u00E1dra a jak jsou tyto procesy koordinov\u00E1ny v \u010Dase tak, aby umo\u017Enily akumulaci repara\u010Dn\u00EDch protein\u016F a v\u011Brn\u00E9 obnoven\u00ED integrity genomu." . . "2014-03-31+02:00"^^ .