"http://www.isvav.cz/projectDetail.do?rowId=GAP301/11/1568"^^ . "The project was focused on studying cellular immune responses in graft tolerance after kidney transplantation. The project characterized in patients with renal graft tolerance changes in monocyte subpopulations and Tregs, and characterized the role of mesenchymal stem cells in cytokine production and induction of tolerance; results were published in 17 articles in journals with impact factor."@en . "tolerance regulatory T cells transplantation"@en . "Transplantation tolerance has not been achieved\u00A0 in the clinic yet.\u00A0Better understanding of mechanisms involved in the alloimmune response is of principle for the development of\u00A0new diagnostics tests for safe weaning therapy\u00A0and for cellular therapy.\u00A0The aim of this project is to generate and characterize suppressive macrophages induced by interactions with tumor cells with respect to their potential use in inhibiting allospecific responses and inducing transplant tolerance, explore the immunosuppressive properties and healing potentials of mesenchymal stem cells after their local and systemic transfer in a mouse model of skin transplantation and finally determine whether increased presence of Tregs and suppressive monocytes along with other novel tolerance markers over one year of prospective monitoring in peripheral blood may be associated with long-term kidney graft function and the absence of rejection. Better understanding of cellular mechanisms of transplantation tolerance may be used in novel and less aggressive therapeutical strategies in organ transplant recipients."@en . "2015-05-22+02:00"^^ . . . . "2011-01-01+01:00"^^ . "2014-12-31+01:00"^^ . . . . "19"^^ . "V klinick\u00E9 medic\u00EDn\u011B se dosud nepoda\u0159ilo navodit transplanta\u010Dn\u00ED toleranci. V\u00A0sou\u010Dasnosti bylo zji\u0161t\u011Bno, \u017Ee imunitn\u00ED regulace je \u0159\u00EDzena jak lymfocyty, tak i ostatn\u00EDmi bu\u0148kami. Lep\u0161\u00ED porozum\u011Bn\u00ED bun\u011B\u010Dn\u00FDm a molekul\u00E1rn\u00EDm mechanism\u016Fm imunitn\u00ED odpov\u011Bdi je z\u00E1sadn\u00ED pro vznik\u00A0test\u016F nezbytn\u00FDch pro minimalizaci imunosuprese a\u00A0pro nov\u00E9 postupy v\u00A0bun\u011B\u010Dn\u00E9 terapii. C\u00EDlem tohoto projektu je generovat a charakterizovat supresivn\u00ED makrof\u00E1gy indukovan\u00E9 n\u00E1dorov\u00FDmi bu\u0148kami a jejich medi\u00E1tory s\u00A0c\u00EDlem potla\u010Dit allospecifickou odpov\u011B\u010F a navodit transplanta\u010Dn\u00ED toleranci, vy\u0161et\u0159it imunosupresivn\u00ED vlastnosti mesenchym\u00E1ln\u00EDch kmenov\u00FDch bun\u011Bk po lok\u00E1ln\u00EDm nebo syst\u00E9mov\u00E9m transferu v\u00A0modelu transplantace k\u016F\u017Ee u my\u0161i a tak\u00E9 zjistit zdali zv\u00FD\u0161en\u00E1 p\u0159\u00EDtomnost regulatorn\u00EDch T lymfocyt\u016F a monocyt\u016F spolu s\u00A0dal\u0161\u00EDmi markery tolerance v\u00A0perifern\u00ED krvi u nemocn\u00FDch po transplantaci ledviny je spojena s\u00A0dlouhodobou funkc\u00ED \u0161t\u011Bp\u016F a absenc\u00ED rejekce. Lep\u0161\u00ED porozum\u011Bn\u00ED bun\u011B\u010Dn\u00FDm mechanism\u016Fm transplanta\u010Dn\u00ED tolerance m\u016F\u017Ee b\u00FDt vyu\u017Eito v\u00A0nov\u00FDch m\u00E9n\u011B agres\u00EDvn\u00EDch l\u00E9\u010Debn\u00FDch strategi\u00EDch po transplantac\u00EDch org\u00E1n\u016F." . "19"^^ . . . . . . . "Cellular aspects of transplantation tolerance"@en . . "Projekt byl zam\u011B\u0159en\u00FD na studium bun\u011B\u010Dn\u00E9 imunity a tolerance \u0161t\u011Bpu u transplantac\u00ED ledvin. \u0158e\u0161itelsk\u00FD t\u00FDm charakterizoval u pacient\u016F s toleranc\u00ED ledvinn\u00E9ho \u0161t\u011Bpu zm\u011Bny v subpopulac\u00EDch monocyt\u016F, regula\u010Dn\u00EDch T-bun\u011Bk a d\u00E1le charakterizoval \u00FAlohu mesenchym\u00E1ln\u00EDch kmenov\u00FDch bun\u011Bk v produkci cytokin\u016F a navozen\u00ED tolerance. \u0158e\u0161itel\u00E9 publikovali celkem 17 \u010Dl\u00E1nk\u016F v \u010Dasopisech s impakt faktorem."@cs . "0"^^ . . . "2014-04-18+02:00"^^ . . . . "1"^^ . . "Bun\u011B\u010Dn\u00E9 aspekty transplanta\u010Dn\u00ED tolerance" . . "GAP301/11/1568" . "1"^^ .