"Systematic research project that aims to study pharmacology of novel anti tumorous drugs on the basis of transition metal-based complexes. Results were published in 26 manuscripts in Journals with IF e.g. NAR or J Med Chem., that belong to respected journals in the field. The project is surely very fruitful and efficiently done."@en . . . "metallodrugs cancer DNA cytotoxicity" . . . "The main objective is to increase knowledge and understanding of the design and mechanisms of action of antitumor metallodrugs, and to use this enhanced knowledge in combination with modern genomic research to develop new classes of metallodrugs with truly novel mechanisms of action and novel spectra of biomedical activity including targeted action. Secondary objectives are: (i) to design and study transition metal-based agents that circumvent known clinical drawbacks of \u201Cconventional\u201D cisplatin and its analogs (resistance, limited spectrum of activity, lack of specificity, side effects) through different molecular-level actions and through molecular and cellular targeting; (ii) enhance our knowledge of the molecular and macromolecular level effects of existing clinical agents and use this knowledge to underpin the process of designing new metallodrugs. Major outcome expected: New targeted metallodrugs will be proposed and the associated biochemistry, molecular biology and pharmacology will be developed and examined to bring novel and more effective drug candidates to clinical trials."@en . "2014-03-31+02:00"^^ . "0"^^ . "1"^^ . "metallodrugs cancer DNA cytotoxicity,antitumor effects mechanism"@en . . "http://www.isvav.cz/projectDetail.do?rowId=GAP301/10/0598"^^ . . "2015-05-22+02:00"^^ . . "Metalofarmaka odvozen\u00E1 od komplex\u016F osmia, platiny a ruthenia. Od mechanistick\u00FDch studi\u00ED k nov\u00E9, \u00FA\u010Dinn\u011Bj\u0161\u00ED chemoterapii rakoviny" . "0"^^ . . . . . "2014-12-31+01:00"^^ . . "Hlavn\u00EDm c\u00EDlem projektu je zdokonalit znalosti o mechanismech protin\u00E1dorov\u00E9ho p\u016Fsoben\u00ED metalofarmak; vyu\u017E\u00EDt nov\u00E9 znalosti v kombinaci s modern\u00EDm v\u00FDzkumem genomu pro n\u00E1vrhy nov\u00FDch typ\u016F metalofarmak, p\u016Fsob\u00EDc\u00EDch zcela nov\u00FDmi mechanismy a vykazuj\u00EDc\u00EDmi nov\u00E9 spektrum protin\u00E1dorov\u00E9ho p\u016Fsoben\u00ED v\u010Detn\u011B c\u00EDlen\u00E9ho. Dal\u0161\u00ED c\u00EDle jsou: i) navrhnout a studovat l\u00E1tky odvozen\u00E9 od komplex\u016F p\u0159echodn\u00FDch kov\u016F, kter\u00E9 umo\u017En\u00ED obej\u00EDt zn\u00E1m\u00E1 omezen\u00ED souvisej\u00EDc\u00ED s klinick\u00FDm vyu\u017Eit\u00EDm konven\u010Dn\u00ED cisplatiny a jej\u00EDch analog\u016F (resistence, omezen\u00E9 spektrum a n\u00EDzk\u00E1 specificita p\u016Fsoben\u00ED, vedlej\u0161\u00ED \u00FA\u010Dinky) na z\u00E1klad\u011B jejich odli\u0161n\u00E9ho p\u016Fsoben\u00ED na molekul\u00E1rn\u00ED a bun\u011B\u010Dn\u00E9 \u00FArovni v\u010Detn\u011B p\u016Fsoben\u00ED c\u00EDlen\u00E9ho; ii) zdokonalit znalosti o efektech l\u00E1tek ji\u017E vyu\u017E\u00EDvan\u00FDch v klinick\u00E9 praxi na molekul\u00E1rn\u00ED (makromolekul\u00E1rn\u00ED) \u00FArovni a podpo\u0159it tak v\u00FDvoj nov\u00FDch metalofarmak. O\u010Dek\u00E1van\u00E9 v\u00FDstupy: Budou navr\u017Eena nov\u00E1 (tak\u00E9 c\u00EDlen\u011B p\u016Fsob\u00EDc\u00ED) metalofarmaka a z\u00EDsk\u00E1ny \u00FAdaje o souvisej\u00EDc\u00EDch biochemick\u00FDch, molekul\u00E1rn\u011B biologick\u00FDch a farmakologick\u00FDch aspektech jejich p\u016Fsoben\u00ED tak, aby bylo mo\u017En\u00E9 navrhnout nov\u00E9 kandid\u00E1ty \u00FA\u010Dinn\u011Bj\u0161\u00EDch l\u00E9\u010Div proti rakovin\u011B pro klinick\u00E9 zkou\u0161ky." . . . . . . . "GAP301/10/0598" . . . "Jedn\u00E1 se o systematick\u00FD v\u00FDzkumn\u00FD projekt s c\u00EDlem studia farmakologie nov\u00FDch protin\u00E1dorov\u00FDch l\u00E9\u010Div na b\u00E1zi komplex\u016F p\u0159echodn\u00FDch kov\u016F. V\u00FDsledky byly publikov\u00E1ny v celkem 26 \u010Dl\u00E1nc\u00EDch s IF mezi nimi\u017E nap\u0159\u00EDklad NAR \u010Di J Med Chem, je\u017E pat\u0159\u00ED mezi respektovan\u00E1 periodika v dan\u00E9m oboru. Jedn\u00E1 se jist\u011B o velmi p\u0159\u00EDnosn\u00FD a\u017E p\u0159\u00EDkladn\u00FD projekt."@cs . "26"^^ . "26"^^ . "Metallodrugs based on osmium, platinum and ruthenium complexes. From mechanistic studies to novel, more efficient chemotherapy of cancer"@en . "2010-01-01+01:00"^^ .