. . . . "0"^^ . "87"^^ . "87"^^ . "Hlavn\u00EDm p\u0159\u00EDnosem byly nov\u00E9 poznatky o po\u0161kozen\u00ED DNA vybran\u00FDmi cytostatiky na modelu lidsk\u00FDch neuroblastom\u016F. Deset stanoven\u00FDch c\u00EDl\u016F bylo pr\u016Fb\u011B\u017En\u011B pln\u011Bno. Vysok\u00FD po\u010Det (68) prac\u00ED s dedikac\u00ED k projektu v \u010Dasopisech s n\u00EDzk\u00FDm a st\u0159edn\u00EDm impaktem a rozs\u00E1hl\u00E1 prezentace v\u00FDsledk\u016F \u0161patnou angli\u010Dtinou v z\u00E1v\u011Bre\u010Dn\u00E9 zpr\u00E1v\u011B nasv\u011Bd\u010Duj\u00ED, \u017Ee projektu by prosp\u011Bla preference kvality nad kvantitou."@cs . . . . "2014-12-31+01:00"^^ . "1"^^ . . "Study of contribution of different DNA-damaging mechanisms to toxicity of cytostatics to human chemosensitive and chemoresistant neuroblastomas"@en . "1"^^ . . . . . "2015-05-22+02:00"^^ . . "Cancer neuroblastoma DNA-targeting DNA-damage treatment"@en . . "Studie participace specifick\u00FDch mechanism\u016F po\u0161kozen\u00ED DNA na cytoxicit\u011B cytostatik v\u016F\u010Di lidsk\u00FDm chemosensitivn\u00EDm a chemorestentn\u00EDm neuroblastom\u016Fm" . "2010-01-01+01:00"^^ . "GAP301/10/0356" . . "New findings about the DNA damage by selected cytostatics represent the main accomplishment of the project. Ten stated goals were achieved in time. High number of papers (68) dedicated to the project in journals with low or medium impact and extensive presentation of results in final report in imperfect English indicate that the project would benefit from preference for quality over quantity."@en . . "2014-06-18+02:00"^^ . "http://www.isvav.cz/projectDetail.do?rowId=GAP301/10/0356"^^ . . . . "Neuroblastoma, a tumor of the peripheral sympathetic nervous system, is the most frequent solid extra cranial tumor in children and is a major cause of death from neoplasia in infancy. Still little improvement in therapeutic options has been made, requiring a need for the development of new therapies. The project addresses still unsettled questions, which of mechanisms of action of DNA-damaging drugs both currently used for treatment of human neuroblastomas (doxorubicin, cis-platin and etoposide) and another anticancer agent decreasing growth of neuroblastomas in vitro, ellipticine, are predominant mechanism(s) responsible for their antitumor action in vitro (neuroblastoma cells) and in vivo (neuroblastoma xenograft tumours). The project will also investigate the effects of hypoxia on efficiencies and mechanisms of actions of these drugs and whether they are capable of inducing chemoresistance in neuroblastomas. Their effects in combination with histone deacetylase inhibitors and mechanisms of such effects in vitro and in vivo are other subjects, which will be studied. Such a study will increase our knowledge to explain the proper function of these drugs on the molecular level, which should be utilized for the development of new therapies for neuroblastomas."@en . . "Neuroblastomy jsou tumory perifern\u00EDho nervov\u00E9ho syst\u00E9mu pat\u0159\u00EDc\u00ED mezi obt\u00ED\u017En\u011B l\u00E9\u010Diteln\u00E9 tumory d\u011Btsk\u00E9 populace. A\u010Dkoliv v\u00FDvoji nov\u00FDch terapi\u00ED\u00A0 t\u00E9to choroby se v\u011Bnuje zna\u010Dn\u00E1 pozornost, st\u00E1le nevede k uspokojiv\u00FDm v\u00FDsledk\u016Fm. C\u00EDlem projektu je pozn\u00E1n\u00ED mechanism\u016F p\u016Fsoben\u00ED protin\u00E1dorov\u00FDch agens na neuroblastomy in vitro (neuroblastomov\u00E9 linie) a in vivo (experiment\u00E1ln\u00ED modely s lidsk\u00FDmi neuroblastomy). Jedn\u00E1 se o protin\u00E1dorov\u00E1 agens zp\u016Fsobuj\u00EDc\u00ED r\u016Fzn\u00E1 po\u0161kozen\u00ED DNA, a to jak b\u011B\u017En\u011B u\u017E\u00EDvan\u00E1 pro l\u00E9\u010Den\u00ED (doxorubicin, cis-platina a etoposid), tak i dal\u0161\u00ED l\u00E1tku, kter\u00E9 sni\u017Euje r\u016Fst neuroblastomov\u00FDch bun\u011B\u010Dn\u00FDch lini\u00ED, ellipticinu. Z\u00E1m\u011Brem projektu je rovn\u011B\u017E pozn\u00E1n\u00ED vlivu hypoxie na \u00FA\u010Dinnost t\u011Bchto l\u00E9\u010Div a jejich mechanismus p\u016Fsoben\u00ED, a pozn\u00E1n\u00ED jejich potenci\u00E1lu indukovat chemoresistenci v neuroblastomov\u00FDch lini\u00EDch. Dal\u0161\u00EDm c\u00EDlem projektu je pozn\u00E1n\u00ED vlivu t\u011Bchto l\u00E9\u010Div na r\u016Fst neuroblastom\u016F in vitro a in vivo a mechanismus jejich p\u016Fsoben\u00ED v kombinaci s inhibitory histondeacetylas. V\u00FDsledky z\u00EDskan\u00E9 touto studii vysv\u011Btl\u00ED aktu\u00E1ln\u00ED mechanismy p\u016Fsoben\u00ED studovan\u00FDch l\u00E9\u010Div na molekul\u00E1rn\u00ED \u00FArovni a p\u0159isp\u011Bj\u00ED k n\u00E1vrhu v\u00FDvoje nov\u00FDch terapeutick\u00FDch postup\u016F v l\u00E9\u010Db\u011B neuroblastom\u016F." .