. . . . "Phospholipids Biomembranes Hazardous metals Heavy metals Transfer across the membrane Cell Phytochelatins Voltammetry Mass spectrometry High performance liquid chromatography Atomic absorption spectroscopy."@en . "2015-04-23+02:00"^^ . . "30"^^ . "1"^^ . "Aspekty transportu rizikov\u00FDch kov\u016F p\u0159es biologick\u00E9 membr\u00E1ny" . "2012-01-01+01:00"^^ . "1"^^ . "30"^^ . "GAP208/12/1645" . . . "http://www.isvav.cz/projectDetail.do?rowId=GAP208/12/1645"^^ . . "0"^^ . . . . "Projekt je zam\u011B\u0159en na objasn\u011Bn\u00ED a modelov\u00E1n\u00ED p\u0159enosu iont\u016F rizikov\u00FDch (t\u011B\u017Ek\u00FDch) kov\u016F (iont\u016F Cd, Pb, Cu, atd.) p\u0159es fosfolipidov\u00E9 biomembr\u00E1ny. Z\u00E1kladn\u00ED kroky zkouman\u00FDch transportn\u00EDch d\u011Bj\u016F budou nejd\u0159\u00EDve objasn\u011Bny na modelov\u00FDch membr\u00E1n\u00E1ch, simuluj\u00EDc\u00ED cytoplazmatick\u00E9 membr\u00E1ny a endomembr\u00E1nov\u00FD syst\u00E9m, se z\u00E1m\u011Brem p\u0159ej\u00EDt ke sledov\u00E1n\u00ED proces\u016F na re\u00E1ln\u00FDch \u010Di sm\u00ED\u0161en\u00FDch biomembr\u00E1n\u00E1ch. V\u00FDsledky navrhovan\u00E9ho projektu p\u0159isp\u011Bj\u00ED p\u0159edev\u0161\u00EDm k objasn\u011Bn\u00ED formy p\u0159epravovan\u00FDch speci\u00ED, tj. voln\u00FDch kationt\u016F a jejich komplex\u016F s n\u011Bkter\u00FDmi men\u0161\u00EDmi biomolekulami (peptidy s vys. obsahem cysteinu, fytochelatiny, n\u00EDzkomolekul\u00E1rn\u00ED org. kyseliny, atd.) a princip\u016F, na nich\u017E je jejich transport realizov\u00E1n. K t\u011Bmto \u00FA\u010Del\u016Fm je pl\u00E1nov\u00E1no vyu\u017Eit\u00ED jedine\u010Dn\u00E9 kombinace rozd\u00EDln\u00FDch metod: elektrochemick\u00FDch (voltametrie, elektrochem. imped. spektroskopie aj.), AAS, HPLC ve spojen\u00ED s hmotnostn\u00ED spektrometri\u00ED s ionizac\u00ED elektrosprejem. Objasn\u011Bn\u00ED transportn\u00EDch proces\u016F (p\u0159es cytoplasmatickou membr\u00E1nu, distribuce a transport v bu\u0148ce, v kompartmentech apod.) p\u0159isp\u00EDv\u00E1 k jejich mo\u017En\u00E9mu ovliv\u0148ov\u00E1n\u00ED (nap\u0159. pro fytoremediaci)." . "Aspects of hazardous metals transfer across biomembranes"@en . . "2014-04-18+02:00"^^ . . "The project is aimed at elucidation and modeling of transport processes of hazardous(heavy)metals (ions of Cd, Pb, Zn etc.) across phospholipid biomembranes.The basic steps of such transport processes must be first elucidated on the model membranes,which should simulate the cytoplasmic membranes and endomembrane system,to enable investigatition of these processes on real or mixed biomembranes.The results of the study will contribute to explanation of the form of transported species, i.e., free cations and their complexes with some smaller biomolecules (cysteine-rich peptides,phytochelatins,low mol.weight org.acids etc.)and of principles,on which the transport is based on. It is intended to use the unique combination of electrochemical methods (voltammetry, elchem. imped. spectroscopy etc.), AAS, and HPLC in combination with electrospray ionization mass spectrometry. Detail elucidation of transport processes (across cytoplasmic biomembranes, distribution and transport into cells, compartments, etc.)contributes to their possible control (e.g., for phytoremediation)."@en . . . . . . "2015-12-31+01:00"^^ . .