. "Teoretick\u00E9 a experiment\u00E1ln\u00ED studie v prebiotick\u00E9 chemii nukleov\u00FDch kyselin" . . "V r\u00E1mci tohoto projektu budeme zkoumat pomoc\u00ED kombinovan\u00E9ho experiment\u00E1ln\u011B-teoretick\u00E9ho p\u0159\u00EDstupu prebiotickou chemii komponent nukleov\u00FDch kyselin. Teoretick\u00E1 \u010D\u00E1st studie bude zalo\u017Eena p\u0159edev\u0161\u00EDm na kvantov\u011B chemick\u00FDch v\u00FDpo\u010Dtech, zat\u00EDmco v experiment\u00E1ln\u00ED \u010D\u00E1sti budeme vyu\u017E\u00EDvat laserov\u00E9ho plazmatu jako laboratorn\u00EDho modelu\u00A0re\u00E1ln\u00FDch proces\u016F iniciace z\u00E1jmov\u00FDch reakc\u00ED. Hlavn\u00ED pozornost bude zam\u011B\u0159ena na synt\u00E9zu nukleov\u00FDch b\u00E1z\u00ED z\u00A0formamidu. Budeme tak\u00E9 srovn\u00E1vat mechanizmus formozov\u00E9 reakce v\u00A0r\u016Fzn\u00FDch prost\u0159ed\u00EDch, nap\u0159. v\u00A0p\u0159\u00EDtomnost\u00ED bor\u00E1t\u016F, ve vod\u011B a ve formamidu. D\u00E1le, pl\u00E1nujeme zkoumat fosforylaci nukleozid\u016F, a to jak ve vodn\u00EDm prost\u0159ed\u00ED tak ve formamidu, a fosforylaci komplex\u016F aldopent\u00F3z s\u00A0bor\u00E1tem. Hlavn\u00ED c\u00EDle projektu jsou (i) popsat kinetiku a termodynamiku proces\u016F, kter\u00E9 by mohly hr\u00E1t \u00FAlohu p\u0159i tvorb\u011B komponent prvn\u00EDho genetick\u00E9ho materi\u00E1lu, (ii) vyhodnotit vliv chemick\u00E9ho prost\u0159ed\u00ED na v\u00FDsledek t\u011Bchto reakc\u00ED, a (iii) charakterizovat strukturu, stabilitu a elektronickou strukturu molekul, kter\u00E9 se \u00FA\u010Dastn\u00ED t\u011Bchto reakc\u00ED.\u00A0" . . "The project was focused on the prebiotic chemistry of nucleic acid components studied by an experimental-theoretical approach. The project was successfully completed at high scientific level. The main result is a new scenario of the origin of the first genetic material based on the high-energy chemistry of formamide. The output of the project was published in 33 papers in impacted journals."@en . "Theoretical and Experimental Studies Related to the Prebiotic Chemistry of Nucleic Acids"@en . . . "1"^^ . . . . "This project is aimed at investigating the prebiotic chemistry of nucleic acids components by means of a combined experimental-theoretical approach. From the side of theory we will use mainly quantum chemical calculations, while the experimental work will be done with laboratory simulation of energetic events with pulsed lasers. In particular, we will address the formamide-based synthesis of nucleobases. In addition, we will compare the mechanism of the formose reaction in various environments, i.e. in the presence of borate minerals, in aqueous solution and in formamide. Further, we plan to study the phosphorylation reaction of nucleosides both in aqueous environment and in formamide as well as the phosphorylation reaction of aldopentose-borate complexes. The main goal of this project is threefold: (i) to give an insight into the kinetics and thermodynamics of the processes that could play a role at creating the components of the first genetic material, (ii) to evaluate the impact of the chemical environment on the outcome of these reactions, and (iii) to characterize the structure, stability and electronic structure of the species involved in them."@en . "2"^^ . . . . . . . "0"^^ . "GAP208/10/2302" . . . "Projekt byl zam\u011B\u0159en na experiment\u00E1ln\u00ED a teoretick\u00E9 studium prebiotick\u00E9 chemie komponent nukleov\u00FDch kyselin. \u0158e\u0161en\u00ED projektu prob\u00EDhalo na vysok\u00E9 v\u011Bdeck\u00E9 \u00FArovni, c\u00EDle byly dosa\u017Eeny. Hlavn\u00EDm v\u00FDsledkem projektu je n\u00E1vrh p\u016Fvodn\u00EDho sc\u00E9n\u00E1\u0159e vzniku prvn\u00EDho genetick\u00E9ho materi\u00E1lu z molekuly formamidu chemick\u00FDmi procesy o vysok\u00E9 energii. V\u00FDstupy projektu jsou shrnuty v 33 \u010Dl\u00E1nc\u00EDch v impaktovan\u00FDch \u010Dasopisech."@cs . . . "2010-01-01+01:00"^^ . "theoretical modelling reactive intermediates purine and pyrimidine bases nucleic acids prebiotic chemistry laboratory simulations laser plasmas high-power lasers"@en . . "2013-06-07+02:00"^^ . "http://www.isvav.cz/projectDetail.do?rowId=GAP208/10/2302"^^ . "51"^^ . "51"^^ . "2013-12-31+01:00"^^ . . "2014-07-01+02:00"^^ .