. "0"^^ . "Projekt byl zam\u011B\u0159en na v\u00FDvoj synt\u00E9z biologicky aktivn\u00EDch heterocyklick\u00FDch peptidomimetik na pevn\u00E9 f\u00E1zi, \u00FAdaje \u0159e\u0161itele jsou adekv\u00E1tn\u00ED. V\u00FDsledky maj\u00ED v\u00FDznam pro p\u0159\u00EDpravu a design biologicky aktivn\u00EDch l\u00E1tek, byly publikov\u00E1ny v 11 publikac\u00EDch ve velmi dobr\u00FDch \u010Dasopisech. V\u00FDkaz o hospoda\u0159en\u00ED obsahuje rozporupln\u00E9 \u00FAdaje."@cs . "http://www.isvav.cz/projectDetail.do?rowId=GAP207/12/0473"^^ . . . . . "2014-12-31+01:00"^^ . "The aim of this proposal is to develop a general methodology for efficient and expeditious solid-phase synthesis of diversely constrained peptidomimetics with complete control of their stereochemistry. The proposed approach encompasses the following critical advantages: 1. Incorporation of fused and bridged peptide backbone constraints during traditional Merrifield solid-phase synthesis without a need to prepare dedicated building blocks for each scaffold. 2. Efficient and expeditious synthesis of so far unexplored peptide backbone constraints. 3. Access to diversity of constraints without a need to develop tailored synthetic route for each constrain unit. 4. Access to compounds with complex framework suitable for systematic study of protein-protein interactions. 5. Potential to produce novel hit/leads and straightforward design and synthesis of targeted libraries for subsequent SAR studies. 6. Applicability of proposed syntheses to automated solid-phase peptide synthesis."@en . . . "Cil tohoto n\u00E1vrhu je v\u00FDvoj obecn\u00E9 metodiky pro efektivn\u00ED a rychlou synt\u00E9zu diverzn\u00EDch peptidomimetik s rigidn\u00ED strukturou na pevn\u00E9 f\u00E1zi s kompletn\u00ED kontrolou jejich stereochemie. Navr\u017Een\u00FD p\u0159\u00EDstup m\u00E1 nasleduj\u00EDc\u00ED kritick\u00E9 v\u00FDhody. 1. Vytvo\u0159en\u00ED fuzovan\u00FDch a p\u0159emost\u011Bn\u00FDch rigidn\u00EDch peptidomimetik b\u011Bhem tradi\u010Dn\u00ED Merrifieldovy synt\u00E9zy v pevn\u00E9 f\u00E1zi bez nutnosti p\u0159ipravovat speci\u00E1ln\u00ED staven\u00ED kameny pro ka\u017Ed\u00FD skelet. 2. Efektivn\u00ED a rychl\u00E1 synt\u00E9za dosud neprob\u00E1dan\u00FDch peptidomimetic s rigidn\u00ED strukturou peptidov\u00E9ho \u0159etezce. 3. P\u0159\u00EDstup k diverzn\u00EDm peptidomimetik\u00E1m s rigidn\u00ED strukturou bez nutnosti vyv\u00EDjet specifickou syntetickou cestu pro ka\u017Ed\u00FD skelet. 4. P\u0159\u00EDstup k l\u00E1tk\u00E1m s komplexn\u00ED strukturou vhodn\u00FDch pro systematick\u00E9 studie protein-protein interakc\u00ED. 5. Potenci\u00E1l k nalezen\u00ED nov\u00FDch hitu/leadu a p\u0159\u00EDmo\u010Dar\u00FD design a synt\u00E9za c\u00EDlen\u00FDch knihoven pro n\u00E1sledn\u00E9 SAR studie. 6. Pou\u017Eitelnost navr\u017Een\u00FDch synt\u00E9z pro automatickou synt\u00E9zu v pevn\u00E9 f\u00E1zi." . "Solid-phase synthesis of diversely constrained peptidomimetics."@en . . . . . . "9"^^ . . "peptidomimetics peptides solid-phase synthesis"@en . "9"^^ . "1"^^ . "GAP207/12/0473" . "Project was focused on the development of syntheses of of biologically active heterocyclic peptidomimetics, the data supplied by the principal investigator are adequate. The results obtained are important for the preparation and design of biologically active compounds, and have been published in 11 papers in impacted journals. The balance sheet contains inconsistent figures."@en . "2012-01-01+01:00"^^ . . . . . . "2015-05-22+02:00"^^ . "2014-03-31+02:00"^^ . "0"^^ . "Synt\u00E9za diverzn\u00EDch peptidomimetik s rigidn\u00ED strukturou na pevn\u00E9 f\u00E1zi." .