. . "Nov\u00E9 t\u0159\u00EDdy kontrastn\u00EDch l\u00E1tek pro tomografii magnetick\u00E9 rezonance" . . "2015-04-23+02:00"^^ . . . . "11"^^ . . . . "Magnetick\u00E1 rezonan\u010Dn\u00ED tomografie (MRI) je jednou z nejv\u00FDznamn\u011Bj\u0161\u00EDch medic\u00EDnsk\u00FDch diagnostick\u00FDch metod. Pro zlep\u0161en\u00ED kontrastu v \u0159ezech sn\u00EDman\u00FDch pomoc\u00ED MRI jsou vyu\u017E\u00EDv\u00E1ny tzv. kontrastn\u00ED l\u00E1tky. Jedn\u00E1 se nej\u010Dast\u011Bji o komplexy iontu Gd3+, ke kter\u00E9mu je koordinov\u00E1na jedna molekula vody. Kontrastn\u00ED l\u00E1tka urychluje relaxaci excitovan\u00E9ho stavu jader vod\u00EDku v\u00A0molekul\u00E1ch vody ve studovan\u00E9m objektu, \u010D\u00EDm\u017E zvy\u0161uje intenzitu m\u011B\u0159en\u00E9ho sign\u00E1lu. V r\u00E1mci tohoto projektu budou p\u0159ipraveny potenci\u00E1ln\u011B \u00FA\u010Dinn\u011Bj\u0161\u00ED kontrastn\u00ED l\u00E1tky obsahuj\u00EDc\u00ED dv\u011B koordinovan\u00E9 molekuly vody k\u00A0centr\u00E1ln\u00EDmu iontu Gd3+. Budou studov\u00E1ny komplexy Mn2+, kter\u00E9 mohou t\u00E9\u017E slou\u017Eit jako kontrastn\u00ED l\u00E1tky; jejich v\u00FDhodou je ni\u017E\u0161\u00ED toxicita Mn2+ v porovn\u00E1n\u00ED s Gd3+, a t\u00E9\u017E obecn\u011B rychlej\u0161\u00ED v\u00FDm\u011Bna koordinovan\u00E9 molekuly vody. Budou p\u0159ipraveny deriv\u00E1ty obsahuj\u00EDc\u00ED fluor, kter\u00FD m\u016F\u017Ee b\u00FDt detekov\u00E1n pomoc\u00ED MRI tomografu. V\u00FDhodou je nulov\u00E9 pozad\u00ED (nulov\u00FD obsah fluoru v organismu). Budou studov\u00E1ny syst\u00E9my saturuj\u00EDc\u00ED sign\u00E1l vody d\u00EDky chemick\u00E9 v\u00FDm\u011Bn\u011B s labiln\u00EDmi protony v\u00E1zan\u00FDmi v kontrastn\u00ED l\u00E1tce (tzv. CEST-kontrastn\u00ED l\u00E1tky); v\u00FDhodou je specificita." . "11"^^ . "Magnetic resonance imaging (MRI) is one of the most important medicinal diagnostic methods. For a better resolution of the images, the substances called contrast agents (CAs) are often administered. They are mostly Gd3+-complexes, which contain one coordinated water molecule. CAs increase relaxation rate of the excited state of water hydrogen nuclei present in the studied object. It leads to increase in the measured signal intensity. In the frame of this project, potentially more efficient contrast agents will be prepared, containing two coordinated water molecules. Complexes of Mn2+ ion will be also studied. They can serve as the CAs, taking the advantage of lower toxicity of Mn2+ comparing to Gd3+, and of generally faster water exchange rate. Derivatives containing fluorine will be prepared. The fluorine nuclei can be easily detected in MRI scanner. The advantage is zero background of this nucleus in the living organisms. The systems bringing the possibility of chemical exchange saturation transfer effect (CEST) will be studied. In MRI, their main advantage is a high specificity."@en . . . "0"^^ . . "GAP207/11/1437" . . "2014-03-31+02:00"^^ . . "gadolinium manganese fluorine MRI PARACEST"@en . "2011-01-01+01:00"^^ . "1"^^ . "http://www.isvav.cz/projectDetail.do?rowId=GAP207/11/1437"^^ . . . . "Novel classes of contrast agents for magnetic resonance imaging"@en . "0"^^ . . "2015-12-31+01:00"^^ .