. . . . "0"^^ . . . . "1"^^ . . "Budeme studovat vliv vz\u00E1jemn\u00FDch interakc\u00ED disulfidov\u00FDch skupin v molekul\u00E1ch peptid\u016F a protein\u016F. Ov\u011B\u0159\u00EDme platnost ji\u017E d\u0159\u00EDve n\u00E1mi nalezen\u00FDch vztah\u016F mezi geometri\u00ED disulfidov\u00E9 skupiny a chiroptick\u00FDmi vlastnostmi (elektronov\u00FDm cirkul\u00E1rn\u00EDm dichroismem - ECD a optickou aktivitou v Ramanov\u00FDch spektrech \u2013 ROA) v situac\u00EDch, kdy je v molekule p\u0159\u00EDtomna v\u00EDce ne\u017Eli jedna takov\u00E1 skupina. Vyhodnot\u00EDme mo\u017Enost detekce a konforma\u010Dn\u00ED anal\u00FDzy disulfidov\u00FDch skupin v p\u0159\u00EDtomnosti skupin amidov\u00FDch. Prostudujeme velikost vz\u00E1jemn\u00FDch interakc\u00ED v elektronov\u00FDch spektrech (po\u010Det dichroick\u00FDch p\u00E1s\u016F a jejich \u0161t\u011Bpen\u00ED) a mo\u017Enosti a limitace separ\u00E1tn\u00EDho pozorov\u00E1n\u00ED jednotliv\u00FDch disulfidov\u00FDch skupin pomoc\u00ED p\u00E1s\u016F C-S a S-S valen\u010Dn\u00EDch vibrac\u00ED v Ramanov\u00FDch a zejm\u00E9na ROA spektrech." . "1"^^ . . "2014-09-08+02:00"^^ . "disulphide group optical activity conformation circular dichroism Raman optical activity"@en . "Interactions of disulfide groups in peptide/ protein molecules - complementary use of electronic and vibrational optical activity"@en . . . "8"^^ . "2010-01-01+01:00"^^ . . "We will study impact of mutual interactions of disulphide groups in peptides and proteins. We would like to verify already established relationship between disulphide geometry and chiroptical properties (electronic circular dichroism - ECD and Raman optical activity - ROA) under the circumstances when more than one disulphide group is present in a molecule. Moreover, possibility to detect and conformationally analyze disulphide groups in a presence of\u00A0 amide groups will be evaluated. We also plan to investigate magnitude of mutual interactions in electronic spectra (number of dichroic bands and their splitting) and possibilities and limitations of observation of individual disulphide groups on the basis of C-S and S-S- stretching vibrational bands in Raman and particularly ROA spectra."@en . "8"^^ . "GAP205/10/1276" . . . . "http://www.isvav.cz/projectDetail.do?rowId=GAP205/10/1276"^^ . . "Interakce disulfidov\u00FDch skupin v molekul\u00E1ch protein\u016F a peptid\u016F - komplement\u00E1rn\u00ED u\u017Eit\u00ED elektronov\u00E9 a vibra\u010Dn\u00ED optick\u00E9 aktivity" . . .