. . "C\u00EDlem je charakterizovat mikrostrukturu a porozitu zbotnal\u00FDch hydrogel\u016F pomoc\u00ED jejich viskoelastick\u00E9 odezvy. Kvalitativn\u00ED a kvantitativn\u00ED faktory popisuj\u00EDc\u00ED velikost a konektivitu p\u00F3r\u016F a architekturu porozity budou nalezeny pomoc\u00ED mechanick\u00FDch spekter z\u00EDskan\u00FDch reologick\u00FDmi m\u011B\u0159en\u00EDmi. Experiment\u00E1ln\u00ED data budou shroma\u017E\u010Fov\u00E1na u relevantn\u00EDch biokompatibiln\u00EDch modelov\u00FDch syst\u00E9m\u016F p\u0159ipravovan\u00FDch a zkou\u0161en\u00FDch pro tk\u00E1\u0148ov\u00E9 in\u017Een\u00FDrstv\u00ED. Chemick\u00E9 slo\u017Een\u00ED hydrogel\u016F bude odpov\u00EDdat aplikaci a budou vyu\u017Eity ji\u017E existuj\u00EDc\u00ED metody p\u0159\u00EDpravy vzork\u016F radik\u00E1lovou polymerizac\u00ED. Definovan\u00FDch porozit bude dosa\u017Eeno bu\u010F f\u00E1zovou separac\u00ED v pr\u016Fb\u011Bhu vzniku gelu nebo budou pou\u017Eity vym\u00FDvateln\u00E9 porogeny. Bude zkoum\u00E1n vliv slo\u017Een\u00ED syst\u00E9mu na f\u00E1zovou separaci a na tvar vznikaj\u00EDc\u00ED struktury a bude sn\u00EDm\u00E1na reologick\u00E1 odezva tak\u00E9 b\u011Bhem tohoto procesu, in situ. Budou nalezeny souvislosti mezi teplotn\u00EDmi a frekven\u010Dn\u00EDmi z\u00E1vislostmi pam\u011B\u0165ov\u00E9ho a ztr\u00E1tov\u00E9ho modulu a kr\u00EDpov\u00FDmi a relaxa\u010Dn\u00EDmi spektry mikrostrukturovan\u00FDch hydrogel\u016F a ochotou bun\u011Bk kolonizovat substr\u00E1t." . . . "Bylo dosa\u017Eeno n\u011Bkolika v\u00FDznamn\u00FDch v\u00FDsledk\u016F (nov\u00FD typ por\u00E9zn\u00EDho hydrogelu, nov\u00E1 metoda m\u011B\u0159en\u00ED gel\u016F, fyzik\u00E1ln\u00ED model chov\u00E1n\u00ED hydrogel\u016F). Do \u0159e\u0161en\u00ED byli zapojeni doktorandi, projekt m\u00E1 i v\u00FDznamn\u00FD aplika\u010Dn\u00ED potenci\u00E1l. Po\u010Det publikac\u00ED v \u010Dasopisech a na konferenc\u00EDch odpov\u00EDd\u00E1 velikosti projektu, dal\u0161\u00ED publikace jsou v recenzn\u00EDm \u0159\u00EDzen\u00ED."@cs . . "MICROSTRUCTURED HYDROGELS FOR TISSUE ENGINEERING: VISCOELASTIC RESPONSES OF GELS OF VARIOUS MORHOLOGIES."@en . "hydrogel viscoelasticity swelling bioengineering tissue engineering"@en . . "2012-01-01+01:00"^^ . "0"^^ . . . "2014-12-31+01:00"^^ . . . "1"^^ . . "The aim is to characterize the microstructure of swollen hydrogels including type of porosity through deep understanding of viscoelastic responses. The qualitative and quantitative parameters describing the size, connectivity and architecture of pores will be revealed by mechanical spectra obtained from rheological measurements. The biocompatible model hydrogels designed for soft tissue engineering will provide the data for the study. The chemical composition of hydrogels will conform to the demands of application. Free-radical crosslinking copolymerization will be the main method of gel synthesis. To generate defined porosity, the reaction induced phase separation and washable porogens will be used. Various additives will be used to vary microstructure by microsyneresis during crosslinking and quantifying factors will be studied by in-situ dynamic rheometry. The temperature and frequency dependence of storage and loss moduli and, the creep and relaxation measurements of microstructured hydrogels will be related and adjusted to the mechanical requirements for the cell cultivation."@en . . . "0"^^ . "MIKROSTRUKTUROVAN\u00C9 HYDROGELY PRO TK\u00C1\u0147OV\u00C9 IN\u017DEN\u00DDRSTV\u00CD: VISKOELASTICK\u00C9 ODEZVY GELU O RUZN\u00C9 MORFOLOGICK\u00C9 STRUKTU\u0158E." . . "2015-05-22+02:00"^^ . "http://www.isvav.cz/projectDetail.do?rowId=GAP108/12/1538"^^ . . "5"^^ . . "It achieved several significant results (a new type of porous hydrogel, a new method of measuring gels, physical model of hydrogels behavior). Doctoral students were involved, the project also has a significant application potential. Number of publications corresponds to the size of the project, other publications are under review."@en . "5"^^ . "GAP108/12/1538" . "2014-03-31+02:00"^^ . . .