"Poran\u011Bn\u00ED m\u00EDchy m\u00E1 za n\u00E1sledek ztr\u00E1tu neuron\u016F a degeneraci axon\u00E1ln\u00EDch v\u00FDb\u011B\u017Ek\u016F proch\u00E1zej\u00EDc\u00EDch l\u00E9z\u00ED. Tyto zm\u011Bny \u010Dasto zp\u016Fsobuj\u00ED v\u00E1\u017Enou funk\u010Dn\u00ED poruchu, kter\u00E1 vede k paraplegii nebo kvadruplegii v z\u00E1vislosti na v\u00FD\u0161ce l\u00E9ze. Jednou ze strategi\u00ED, vedouc\u00ED k obnov\u011B funkc\u00ED a oprav\u011B l\u00E9ze, je p\u0159emost\u011Bn\u00ED l\u00E9ze syntetick\u00FDmi matricemi (samotn\u00FDmi nebo obsahuj\u00EDc\u00EDmi r\u016Fzn\u00E9 bun\u011B\u010Dn\u00E9 populace). Biomateri\u00E1l by m\u011Bl b\u00FDt neimunogenn\u00ED a biodegradovateln\u00FD p\u0159im\u011B\u0159enou rychlost\u00ED v\u00A0\u0159\u00E1du m\u011Bs\u00EDc\u016F. Navrhovan\u00FD projekt spojuje dva nov\u00E9 slibn\u00E9 p\u0159\u00EDstupy ke konstrukci matric pro opravu nervov\u00E9 tk\u00E1n\u011B: (1) Pomalu biodegradovateln\u00E9 matrice na b\u00E1zi syntetick\u00FDch polymer\u016F s\u00ED\u0165ovan\u00FDch reverzibiln\u011B a ireverzibiln\u011B thioly degradovateln\u00FDmi disulfidov\u00FDmi vazbami. (2) P\u0159ipraven\u00E9 matrice budou kovalentn\u011B funkcionalizov\u00E1ny agonisty neurotransmiter\u016F acetylcholinu a serotoninu pro podporu opravy nervov\u00E9 tk\u00E1n\u011B. Na in vitro a in vivo modelech budou testov\u00E1ny schopnosti materi\u00E1l\u016F podpo\u0159it r\u016Fst a diferenciaci kmenov\u00FDch a progenitorov\u00FDch bun\u011Bk a vr\u016Fst\u00E1n\u00ED neur\u00E1ln\u00EDch bun\u011Bk hostitele." . "9"^^ . "Nov\u00E1 generace reduktivn\u011B biodegradovateln\u00FDch funkcionalizovan\u00FDch matric pro tk\u00E1\u0148ov\u00E9 in\u017Een\u00FDrstv\u00ED nervov\u00E9ho syst\u00E9mu" . "1"^^ . . . "macroporous scaffold neural tissue engineering polymer hydrogel"@en . "1"^^ . "Spinal cord injury causes a loss of neurons and the degeneration of axons passing through the lesion. These changes often result in paraplegia or tetraplegia depending on the site of the injury. One of the strategies for lesion repair is bridging the lesion with synthetic scaffolds (nonseeded or seeded with various cell populations). The scaffold should be nonimmunogenic and biodegradable on the order of several months.The proposed project merges two new promising approaches to the construction of scaffolds for nervous tissue repair: (1) Slowly degradable scaffolds based on synthetic polymers crosslinked with reversibly or irreversibly thiol-degradable bonds; (2) The scaffolds will be covalently functionalized with acetylcholine and serotonin agonists to support nervous tissue repair. The ability of the scaffolds to support the growth and differentiation of stem and progenitor cells and the ingrowth of host neural cells will be tested in both in vitro and in vivo models."@en . . . . "2013-06-06+02:00"^^ . . . "New generation of reductively biodegradable functionalized macroporous scaffolds for neural tissue engineering"@en . . "0"^^ . . "2010-01-01+01:00"^^ . . . "2014-07-01+02:00"^^ . "http://www.isvav.cz/projectDetail.do?rowId=GAP108/10/1560"^^ . . . . . . . "2013-12-31+01:00"^^ . "Projekt poskytuje modern\u00ED materi\u00E1ly s obsahem neurotransmiter\u016F pro tk\u00E1\u0148ov\u00E9 in\u017Een\u00FDrstv\u00ED. V\u00FDsledky \u0159e\u0161en\u00ED projektu byly publikov\u00E1ny v 9 \u010Dl\u00E1nc\u00EDch Jimp (jen 2 z nich byly publikov\u00E1ny ob\u011Bma skupinami), ve t\u0159ech kapitol\u00E1ch v knize a na \u010Dty\u0159ech mezin\u00E1rodn\u00EDch konferenc\u00EDch. Panel P108 hodnot\u00ED v\u00FDsledky \u0159e\u0161en\u00ED jako spln\u011Bno."@cs . . "GAP108/10/1560" . . . "9"^^ . "Project provide scaffolds for tissue engineering containing neurotransmitters. Potential of the project was not fully accomplished. Results of the project were published in 9 papers in IF journals (only 2 of them were published by both groups), 3 chapters in books and 4 international conferences. Panel P108 evaluates obtained results as accomplished."@en .