"Deriv\u00E1ty fosgenu pro nanotechnologie" . . . . . . "2011-01-01+01:00"^^ . . "http://www.isvav.cz/projectDetail.do?rowId=GAP106/11/0058"^^ . . "2013-06-07+02:00"^^ . . "2013-12-31+01:00"^^ . "Phosgene Derivatives for Nanotechnologies"@en . "8"^^ . "GAP106/11/0058" . . . "phosgene block copolymers hybrid nanomaterials enantioselectivity drug delivery"@en . "8"^^ . "0"^^ . . . "Phosgene chemistry was successfully employed to prepare functionalised poly(ethylene glycols) and their copolymers with poly(amino acids) potentially utilisable as drug carriers or enantioselective catalysts. Applicability of conjugates of the prepared copolymers with various compounds was successfully tested for these applications.The project fully achieved declared objectives on excellent level."@en . . "V r\u00E1mci projektu bylo \u00FAsp\u011B\u0161n\u011B vyu\u017Eito fosgenov\u00E9 chemie k synt\u00E9ze funkcionalizovan\u00FDch polyetylenglykol\u016F a jejich kopolymer\u016F s polyaminokyselinami potencion\u00E1ln\u011B vyu\u017Eiteln\u00FDch jako nosi\u010De l\u00E9\u010Div nebo v enantioselektivn\u00ED katal\u00FDze.Vhodnost vyu\u017Eit\u00ED pro tyto aplikace byla \u00FAsp\u011B\u0161n\u011B otestov\u00E1na na konjug\u00E1tech t\u011Bchto kopolymer\u016F s r\u016Fzn\u00FDmi slou\u010Deninami. Projekt dos\u00E1hnul pln\u011B deklarovan\u00E9 c\u00EDle na vynikaj\u00EDc\u00ED \u00FArovni."@cs . "1"^^ . "2014-07-01+02:00"^^ . . . "The proposal submits a concept of application of phosgene processing technology to preparation of new systems with nanostructure properties designed for chemical and medicinal purposes. The proposal makes use of synthetic method of N-carboxanhydrides of amino acids, chloroformates and carbonates for synthesis of substituted block copolymers of poly(ethylene glycols) with poly(amino acids) (PEG-b-p(AA)) and chiral polyamines (PEG-b-pA) with self-assembly properties. It is intended to prepare and characterise their modular sets and derived hybrid nanomaterials with palladium. In the field of nanomedicine, PEG-b-p(AA) are designed for targeting carriers of antibiotics. The efficiency of prepared sets PEG-b-p(AA) and PEG-b-pA and their hybrid nanomaterials for enantioselective catalysis will be tested using aldolisation, epoxidation, and reduction reactions."@en . . "Je p\u0159edlo\u017Eena koncepce vyu\u017Eit\u00ED technologi\u00ED zpracov\u00E1n\u00ED fosgenu k\u00A0p\u0159\u00EDprav\u011B nov\u00FDch syst\u00E9m\u016F s\u00A0vlastnostmi nanostruktur kter\u00E9 jsou ur\u010Deny pro chemick\u00E9 a medicin\u00E1ln\u00ED aplikace. N\u00E1vrh vyu\u017E\u00EDv\u00E1 metody synt\u00E9zy N-karboxanhydrid\u016F vybran\u00FDch aminokyselin, chloroformi\u00E1t\u016F a karbon\u00E1t\u016F pro synt\u00E9zu substituovan\u00FDch blokov\u00FDch kopolymer\u016F poly(ethylenglykolu) s\u00A0poly(aminokyselinami) (PEG-b-p(AA)) a chir\u00E1ln\u00EDmi polyaminy (PEG-b-pA) se samoskladn\u00FDmi vlastnostmi. \u00A0Budou p\u0159ipraveny a charakterizov\u00E1ny jejich modul\u00E1rn\u00ED sety a odvozen\u00E9 hybridn\u00ED nanomateri\u00E1ly s\u00A0palladiem. Pro\u00A0nanomedic\u00EDnu jsou ur\u010Deny PEG-b-p(AA) jako sm\u011Brovan\u00E9 nosi\u010De antibiotik. \u00DA\u010Dinnost p\u0159ipraven\u00FDch set\u016F PEG-b-p(AA) a PEG-b-pA a jejich hybridn\u00EDch nanomateri\u00E1l\u016F pro enantioselektivn\u00ED katal\u00FDzu bude testov\u00E1na u aldoliza\u010Dn\u00ED, epoxida\u010Dn\u00ED a reduk\u010Dn\u00ED reakce." . . . "0"^^ .